Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease: Risk to relatives for airflow obstruction and chronic bronchitis

Severe alpha-1-antitrypsin deficiency is the only proven genetic risk factor for chronic obstructive pulmonary disease (COPD). We have assembled a cohort of 44 probands with severe, early-onset COPD, who do not have severe alpha-1-antitrypsin deficiency. A surprisingly high prevalence of females (79...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 1998-06, Vol.157 (6), p.1770-1778
Hauptverfasser:	SILVERMAN, E. K, CHAPMAN, H. A, WAIN, J, SPEIZER, F. E, DRAZEN, J. M, WEISS, S. T, ROSNER, B, CAMPBELL, E. J, O'DONNELL, W. J, REILLY, J. J, GINNS, L, MENTZER, S
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 1-Antitrypsin Deficiency - complications Biological and medical sciences Bronchitis - etiology Bronchitis - genetics Chronic Disease Chronic obstructive pulmonary disease, asthma Female Forced Expiratory Volume Humans Lung Diseases, Obstructive - etiology Lung Diseases, Obstructive - genetics Lung Diseases, Obstructive - physiopathology Male Medical sciences Middle Aged Pneumology Risk Factors Smoking - adverse effects Vital Capacity
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