PET and P300 relationships in early Alzheimer's disease
The P300 (P3) wave of the auditory brain event-related potential was investigated in patients with probable Alzheimer's disease to determine whether P300 latency discriminated these patients from controls and whether prolonged P300 latency correlated with rates of brain glucose metabolism as me...
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| Veröffentlicht in: | Neurobiology of aging 1990-07, Vol.11 (4), p.471-476 |
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| container_issue | 4 |
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| container_title | Neurobiology of aging |
| container_volume | 11 |
| creator | Marsh, James T. Schubarth, Glena Brown, Warren S. Riege, Walter Strandburg, Robert Dorsey, Deborah Maltese, Adrianne Kuhl, David |
| description | The P300 (P3) wave of the auditory brain event-related potential was investigated in patients with probable Alzheimer's disease to determine whether P300 latency discriminated these patients from controls and whether prolonged P300 latency correlated with rates of brain glucose metabolism as measured by Positron Emission Tomography. P300 latency was prolonged by more than 1.5 standard deviations from age expectancy in 14 of 18 patients, but none of 17 controls. In these subjects P300 latency was shown to be inversely correlated with relative metabolic rates of parietal and, to a lesser extent, temporal and frontal association areas, but not with subcortical areas. |
| doi_str_mv | 10.1016/0197-4580(90)90015-R |
| format | Article |
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P300 latency was prolonged by more than 1.5 standard deviations from age expectancy in 14 of 18 patients, but none of 17 controls. In these subjects P300 latency was shown to be inversely correlated with relative metabolic rates of parietal and, to a lesser extent, temporal and frontal association areas, but not with subcortical areas.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/0197-4580(90)90015-R</identifier><identifier>PMID: 2381507</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Aged ; Alzheimer Disease - diagnosis ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - metabolism ; Alzheimer's disease ; Biological and medical sciences ; Brain - diagnostic imaging ; Brain - metabolism ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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P300 latency was prolonged by more than 1.5 standard deviations from age expectancy in 14 of 18 patients, but none of 17 controls. In these subjects P300 latency was shown to be inversely correlated with relative metabolic rates of parietal and, to a lesser extent, temporal and frontal association areas, but not with subcortical areas.</description><subject>Aged</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Event-related potentials</subject><subject>Evoked Potentials, Auditory</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>P300</subject><subject>Positron Emission Tomography</subject><subject>Radiography</subject><subject>Tomography, Emission-Computed</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMotVbfQGE23hajJ81kkmyEUuoFCpZS1yFNztDIdKYmrVCf3hla6k44cBb_hZ-PkEsKDxRo_ghUiTTjEu4U3CsAytPpEelSzmVKMyWOSfdgOSVnMX4CgMhE3iGdPpOUg-gSMRnNElO5ZMIAkoClWfu6igu_iomvEjSh3CaD8meBfonhNibORzQRz8lJYcqIF_vfIx_Po9nwNR2_v7wNB-PU8r5cpyoX7ZSMCVVI5AKlknMruGNKSAa5s0wBV8wx4woJhROgcmMsLSiiocB65GbXuwr11wbjWi99tFiWpsJ6E7VQqi-Zoo0x2xltqGMMWOhV8EsTtpqCbnnpFoZuYWjVXsNLT5vY1b5_M1-iO4T2gBr9eq-baE1ZBFNZH_-6VQ4g83bn086HDYxvj0FH67Gy6HxAu9au9v8P-QVh24Ql</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Marsh, James T.</creator><creator>Schubarth, Glena</creator><creator>Brown, Warren S.</creator><creator>Riege, Walter</creator><creator>Strandburg, Robert</creator><creator>Dorsey, Deborah</creator><creator>Maltese, Adrianne</creator><creator>Kuhl, David</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900701</creationdate><title>PET and P300 relationships in early Alzheimer's disease</title><author>Marsh, James T. ; Schubarth, Glena ; Brown, Warren S. ; Riege, Walter ; Strandburg, Robert ; Dorsey, Deborah ; Maltese, Adrianne ; Kuhl, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-96714974379f8e57e898bc75d3978306dc390593d3adf80fd7096aac1f1eea103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Aged</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - diagnostic imaging</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Event-related potentials</topic><topic>Evoked Potentials, Auditory</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>P300</topic><topic>Positron Emission Tomography</topic><topic>Radiography</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marsh, James T.</creatorcontrib><creatorcontrib>Schubarth, Glena</creatorcontrib><creatorcontrib>Brown, Warren S.</creatorcontrib><creatorcontrib>Riege, Walter</creatorcontrib><creatorcontrib>Strandburg, Robert</creatorcontrib><creatorcontrib>Dorsey, Deborah</creatorcontrib><creatorcontrib>Maltese, Adrianne</creatorcontrib><creatorcontrib>Kuhl, David</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marsh, James T.</au><au>Schubarth, Glena</au><au>Brown, Warren S.</au><au>Riege, Walter</au><au>Strandburg, Robert</au><au>Dorsey, Deborah</au><au>Maltese, Adrianne</au><au>Kuhl, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PET and P300 relationships in early Alzheimer's disease</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>1990-07-01</date><risdate>1990</risdate><volume>11</volume><issue>4</issue><spage>471</spage><epage>476</epage><pages>471-476</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>The P300 (P3) wave of the auditory brain event-related potential was investigated in patients with probable Alzheimer's disease to determine whether P300 latency discriminated these patients from controls and whether prolonged P300 latency correlated with rates of brain glucose metabolism as measured by Positron Emission Tomography. 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| ispartof | Neurobiology of aging, 1990-07, Vol.11 (4), p.471-476 |
| issn | 0197-4580 1558-1497 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Alzheimer Disease - diagnosis Alzheimer Disease - diagnostic imaging Alzheimer Disease - metabolism Alzheimer's disease Biological and medical sciences Brain - diagnostic imaging Brain - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Event-related potentials Evoked Potentials, Auditory Glucose - metabolism Humans Medical sciences Middle Aged Neurology P300 Positron Emission Tomography Radiography Tomography, Emission-Computed |
| title | PET and P300 relationships in early Alzheimer's disease |
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