Effect of inhaled interleukin-4 on airway hyperreactivity in asthmatics
lnterleukin-4 (IL-4) has been shown to play a crucial role in the pathogenesis of allergic disease including bronchial asthma. In order to investigate the role of IL-4 in airway hyperreactivity, we investigated the effect of inhaled recombinant human IL-4 on airway responsiveness to methacholine and...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 1998-06, Vol.157 (6), p.1818-1821 |
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| container_title | American journal of respiratory and critical care medicine |
| container_volume | 157 |
| creator | SHI, H.-Z DENG, J.-M HUI XU NONG, Z.-X XIAO, C.-Q LIU, Z.-M QIN, S.-M JIANG, H.-X LIU, G.-N CHEN, Y.-Q |
| description | lnterleukin-4 (IL-4) has been shown to play a crucial role in the pathogenesis of allergic disease including bronchial asthma. In order to investigate the role of IL-4 in airway hyperreactivity, we investigated the effect of inhaled recombinant human IL-4 on airway responsiveness to methacholine and eosinophil numbers in induced sputum in eight patients with allergic asthma using a placebo-controlled study design. Our results demonstrated that in the control experiments receiving vehicle inhalation, methacholine PC20 values did not change nor did the numbers of eosinophils in sputum change from baseline values. In contrast, after IL-4 inhalation, methacholine PC20 fell from baseline (0.43 +/- 1.81 mg/mI) to 0.22 +/- 1.73 mg/mI (p < 0.01) at 24 h, and to 0.21 +/- 1. 74 mg/ml (p < 0.01) at 48 h. Accompanying this increased airway sensitivity was a significant eosinophilia in sputum. Our data indicated that IL-4 increases airway responsiveness by recruiting eosinophils into the airway in patients with allergic bronchial asthma. |
| doi_str_mv | 10.1164/ajrccm.157.6.9710023 |
| format | Article |
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In order to investigate the role of IL-4 in airway hyperreactivity, we investigated the effect of inhaled recombinant human IL-4 on airway responsiveness to methacholine and eosinophil numbers in induced sputum in eight patients with allergic asthma using a placebo-controlled study design. Our results demonstrated that in the control experiments receiving vehicle inhalation, methacholine PC20 values did not change nor did the numbers of eosinophils in sputum change from baseline values. In contrast, after IL-4 inhalation, methacholine PC20 fell from baseline (0.43 +/- 1.81 mg/mI) to 0.22 +/- 1.73 mg/mI (p < 0.01) at 24 h, and to 0.21 +/- 1. 74 mg/ml (p < 0.01) at 48 h. Accompanying this increased airway sensitivity was a significant eosinophilia in sputum. Our data indicated that IL-4 increases airway responsiveness by recruiting eosinophils into the airway in patients with allergic bronchial asthma.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/ajrccm.157.6.9710023</identifier><identifier>PMID: 9620911</identifier><language>eng</language><publisher>New York, NY: American Lung Association</publisher><subject>Administration, Inhalation ; Adolescent ; Adult ; Allergic diseases ; Asthma - physiopathology ; Biological and medical sciences ; Bronchial Hyperreactivity - physiopathology ; Bronchial Provocation Tests ; Eosinophils ; Female ; Humans ; Immunopathology ; Interleukin-4 - administration & dosage ; Leukocyte Count ; Male ; Medical sciences ; Methacholine Chloride ; Middle Aged ; Recombinant Proteins - administration & dosage ; Respiratory and ent allergic diseases ; Sputum - cytology ; Tropical medicine</subject><ispartof>American journal of respiratory and critical care medicine, 1998-06, Vol.157 (6), p.1818-1821</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-32e1f49515e626c5f7545b72b01629cf0a6af0b696a71909fe853eae4a2ba29e3</citedby><cites>FETCH-LOGICAL-c428t-32e1f49515e626c5f7545b72b01629cf0a6af0b696a71909fe853eae4a2ba29e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4023,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2302050$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9620911$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHI, H.-Z</creatorcontrib><creatorcontrib>DENG, J.-M</creatorcontrib><creatorcontrib>HUI XU</creatorcontrib><creatorcontrib>NONG, Z.-X</creatorcontrib><creatorcontrib>XIAO, C.-Q</creatorcontrib><creatorcontrib>LIU, Z.-M</creatorcontrib><creatorcontrib>QIN, S.-M</creatorcontrib><creatorcontrib>JIANG, H.-X</creatorcontrib><creatorcontrib>LIU, G.-N</creatorcontrib><creatorcontrib>CHEN, Y.-Q</creatorcontrib><title>Effect of inhaled interleukin-4 on airway hyperreactivity in asthmatics</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>lnterleukin-4 (IL-4) has been shown to play a crucial role in the pathogenesis of allergic disease including bronchial asthma. In order to investigate the role of IL-4 in airway hyperreactivity, we investigated the effect of inhaled recombinant human IL-4 on airway responsiveness to methacholine and eosinophil numbers in induced sputum in eight patients with allergic asthma using a placebo-controlled study design. Our results demonstrated that in the control experiments receiving vehicle inhalation, methacholine PC20 values did not change nor did the numbers of eosinophils in sputum change from baseline values. In contrast, after IL-4 inhalation, methacholine PC20 fell from baseline (0.43 +/- 1.81 mg/mI) to 0.22 +/- 1.73 mg/mI (p < 0.01) at 24 h, and to 0.21 +/- 1. 74 mg/ml (p < 0.01) at 48 h. Accompanying this increased airway sensitivity was a significant eosinophilia in sputum. Our data indicated that IL-4 increases airway responsiveness by recruiting eosinophils into the airway in patients with allergic bronchial asthma.</description><subject>Administration, Inhalation</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Allergic diseases</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Bronchial Hyperreactivity - physiopathology</subject><subject>Bronchial Provocation Tests</subject><subject>Eosinophils</subject><subject>Female</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Interleukin-4 - administration & dosage</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methacholine Chloride</subject><subject>Middle Aged</subject><subject>Recombinant Proteins - administration & dosage</subject><subject>Respiratory and ent allergic diseases</subject><subject>Sputum - cytology</subject><subject>Tropical medicine</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtrGzEUhUVJSZO0_6CFWYTuxrnS6GEtg3HTgCGbFLITd5QrLHcerjRO8L-PiodsszoX7nfO4mPsO4cF51re4C553y-4Mgu9sIYDiOYTu-CqUbW0Bs7KDaappbRPX9hlzjsALpYcztm51QIs5xfsbh0C-akaQxWHLXb0XHKi1NHhbxxqWY1DhTG94rHaHveUEqGf4kucjoWrME_bHqfo81f2OWCX6ducV-zPr_Xj6ne9ebi7X91uai_FcqobQTxIq7giLbRXwSipWiNa4FpYHwA1Bmi11Wi4BRtoqRpCkihaFJaaK_bztLtP478D5cn1MXvqOhxoPGRnrBXGSvMhWAzKsm0LKE-gT2POiYLbp9hjOjoO7r9odxLtimin3Sy61H7M-4e2p-f30my2_K_nP2aPXUg4-JjfMdGAAAXNG7yfh00</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>SHI, H.-Z</creator><creator>DENG, J.-M</creator><creator>HUI XU</creator><creator>NONG, Z.-X</creator><creator>XIAO, C.-Q</creator><creator>LIU, Z.-M</creator><creator>QIN, S.-M</creator><creator>JIANG, H.-X</creator><creator>LIU, G.-N</creator><creator>CHEN, Y.-Q</creator><general>American Lung Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980601</creationdate><title>Effect of inhaled interleukin-4 on airway hyperreactivity in asthmatics</title><author>SHI, H.-Z ; DENG, J.-M ; HUI XU ; NONG, Z.-X ; XIAO, C.-Q ; LIU, Z.-M ; QIN, S.-M ; JIANG, H.-X ; LIU, G.-N ; CHEN, Y.-Q</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-32e1f49515e626c5f7545b72b01629cf0a6af0b696a71909fe853eae4a2ba29e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Administration, Inhalation</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Allergic diseases</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Bronchial Hyperreactivity - physiopathology</topic><topic>Bronchial Provocation Tests</topic><topic>Eosinophils</topic><topic>Female</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Interleukin-4 - administration & dosage</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methacholine Chloride</topic><topic>Middle Aged</topic><topic>Recombinant Proteins - administration & dosage</topic><topic>Respiratory and ent allergic diseases</topic><topic>Sputum - cytology</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHI, H.-Z</creatorcontrib><creatorcontrib>DENG, J.-M</creatorcontrib><creatorcontrib>HUI XU</creatorcontrib><creatorcontrib>NONG, Z.-X</creatorcontrib><creatorcontrib>XIAO, C.-Q</creatorcontrib><creatorcontrib>LIU, Z.-M</creatorcontrib><creatorcontrib>QIN, S.-M</creatorcontrib><creatorcontrib>JIANG, H.-X</creatorcontrib><creatorcontrib>LIU, G.-N</creatorcontrib><creatorcontrib>CHEN, Y.-Q</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHI, H.-Z</au><au>DENG, J.-M</au><au>HUI XU</au><au>NONG, Z.-X</au><au>XIAO, C.-Q</au><au>LIU, Z.-M</au><au>QIN, S.-M</au><au>JIANG, H.-X</au><au>LIU, G.-N</au><au>CHEN, Y.-Q</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of inhaled interleukin-4 on airway hyperreactivity in asthmatics</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>1998-06-01</date><risdate>1998</risdate><volume>157</volume><issue>6</issue><spage>1818</spage><epage>1821</epage><pages>1818-1821</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>lnterleukin-4 (IL-4) has been shown to play a crucial role in the pathogenesis of allergic disease including bronchial asthma. In order to investigate the role of IL-4 in airway hyperreactivity, we investigated the effect of inhaled recombinant human IL-4 on airway responsiveness to methacholine and eosinophil numbers in induced sputum in eight patients with allergic asthma using a placebo-controlled study design. Our results demonstrated that in the control experiments receiving vehicle inhalation, methacholine PC20 values did not change nor did the numbers of eosinophils in sputum change from baseline values. In contrast, after IL-4 inhalation, methacholine PC20 fell from baseline (0.43 +/- 1.81 mg/mI) to 0.22 +/- 1.73 mg/mI (p < 0.01) at 24 h, and to 0.21 +/- 1. 74 mg/ml (p < 0.01) at 48 h. Accompanying this increased airway sensitivity was a significant eosinophilia in sputum. Our data indicated that IL-4 increases airway responsiveness by recruiting eosinophils into the airway in patients with allergic bronchial asthma.</abstract><cop>New York, NY</cop><pub>American Lung Association</pub><pmid>9620911</pmid><doi>10.1164/ajrccm.157.6.9710023</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete; American Thoracic Society (ATS) Journals Online; EZB-FREE-00999 freely available EZB journals |
| subjects | Administration, Inhalation Adolescent Adult Allergic diseases Asthma - physiopathology Biological and medical sciences Bronchial Hyperreactivity - physiopathology Bronchial Provocation Tests Eosinophils Female Humans Immunopathology Interleukin-4 - administration & dosage Leukocyte Count Male Medical sciences Methacholine Chloride Middle Aged Recombinant Proteins - administration & dosage Respiratory and ent allergic diseases Sputum - cytology Tropical medicine |
| title | Effect of inhaled interleukin-4 on airway hyperreactivity in asthmatics |
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