Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test
It has been shown recently that the fraction IIIc of a crude extract of Hypericum perforatum, (St. John's wort) that contained both hypericin (1) and pseudohypericin (2), was remarkably active in the rats forced swimming test (FST) after Porsolt. However, neither of the naphthodianthrones isola...
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| Veröffentlicht in: | Planta medica 1998-05, Vol.64 (4), p.291-294 |
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| creator | Butterweck, V Petereit, F Winterhoff, H Nahrstedt, A |
| description | It has been shown recently that the fraction IIIc of a crude extract of Hypericum perforatum, (St. John's wort) that contained both hypericin (1) and pseudohypericin (2), was remarkably active in the rats forced swimming test (FST) after Porsolt. However, neither of the naphthodianthrones isolated from this fraction were sufficiently effective when administered suspended in water. The solubility of 1 and 2 is remarkably increased in the presence of a fraction containing procyanidins, especially procyanidin B2, which is present also in the active Hypericum fraction IIIc. The cooperative effect of procyanidins significantly increased the in vivo effects of 1 and 2, which exhibited inverted U-shaped dose response curves, in the FST. The anti-immobility effect of solubilized 1 and 2 was antagonized by the dopamine antagonist sulpiride. These data indicate that naphthodianthrones are antidepressant constituents of H. perforatum and suggest that the dopaminergic system is involved in their action. |
| doi_str_mv | 10.1055/s-2006-957437 |
| format | Article |
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However, neither of the naphthodianthrones isolated from this fraction were sufficiently effective when administered suspended in water. The solubility of 1 and 2 is remarkably increased in the presence of a fraction containing procyanidins, especially procyanidin B2, which is present also in the active Hypericum fraction IIIc. The cooperative effect of procyanidins significantly increased the in vivo effects of 1 and 2, which exhibited inverted U-shaped dose response curves, in the FST. The anti-immobility effect of solubilized 1 and 2 was antagonized by the dopamine antagonist sulpiride. These data indicate that naphthodianthrones are antidepressant constituents of H. perforatum and suggest that the dopaminergic system is involved in their action.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2006-957437</identifier><identifier>PMID: 9619107</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>activity ; Animals ; antidepressants ; Antidepressive Agents - therapeutic use ; Biological and medical sciences ; chemical constituents of plants ; fractionation ; General pharmacology ; Hypericum perforatum ; Male ; Medical sciences ; medicinal properties ; metabolites ; naphthodianthrones ; neuropharmacology ; Perylene - analogs & derivatives ; Perylene - chemistry ; Perylene - therapeutic use ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; procyanidins ; Rats ; Solubility ; Stress, Psychological - drug therapy ; Swimming</subject><ispartof>Planta medica, 1998-05, Vol.64 (4), p.291-294</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2242619$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9619107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Butterweck, V</creatorcontrib><creatorcontrib>Petereit, F</creatorcontrib><creatorcontrib>Winterhoff, H</creatorcontrib><creatorcontrib>Nahrstedt, A</creatorcontrib><title>Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>It has been shown recently that the fraction IIIc of a crude extract of Hypericum perforatum, (St. John's wort) that contained both hypericin (1) and pseudohypericin (2), was remarkably active in the rats forced swimming test (FST) after Porsolt. However, neither of the naphthodianthrones isolated from this fraction were sufficiently effective when administered suspended in water. The solubility of 1 and 2 is remarkably increased in the presence of a fraction containing procyanidins, especially procyanidin B2, which is present also in the active Hypericum fraction IIIc. The cooperative effect of procyanidins significantly increased the in vivo effects of 1 and 2, which exhibited inverted U-shaped dose response curves, in the FST. The anti-immobility effect of solubilized 1 and 2 was antagonized by the dopamine antagonist sulpiride. These data indicate that naphthodianthrones are antidepressant constituents of H. perforatum and suggest that the dopaminergic system is involved in their action.</description><subject>activity</subject><subject>Animals</subject><subject>antidepressants</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>chemical constituents of plants</subject><subject>fractionation</subject><subject>General pharmacology</subject><subject>Hypericum perforatum</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicinal properties</subject><subject>metabolites</subject><subject>naphthodianthrones</subject><subject>neuropharmacology</subject><subject>Perylene - analogs & derivatives</subject><subject>Perylene - chemistry</subject><subject>Perylene - therapeutic use</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>procyanidins</subject><subject>Rats</subject><subject>Solubility</subject><subject>Stress, Psychological - drug therapy</subject><subject>Swimming</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LxDAQxYMo6_px9CjmIN6qySRpm6Ms6gqCB_Vc0jRZI_0ySdUV_N8N7KKnNzPvN_NgEDqh5JISIa5CBoTkmRQFZ8UOmlPOZEYA6C6aE8IgI5KzfXQQwhshlEtCZmgmcyopKebo52lop9q17ts0-HU9Gu-067HqGzwGMzXD_8z6ocPLTTt1OKkdvIqpNF_Gx7QTXWNGb0JIJVY6ug8X1zitxleDE6xTRvh0Xef6FY4mxCO0Z1UbzPFWD9HL7c3zYpk9PN7dL64fMgtCxqymJdQl53kuBWM5A9DSaMkUr60lrKA8B64ZlUKDEbUSsshLrg3numAWKDtEF5u7ox_epxRcdS5o07aqN8MUqkJKKISUCTzdglPdmaYaveuUX1fbfyX_fOuroFVrveq1C38YAIdEJuxsg1k1VGrlE_LyBIQyAmUpKGPsF89mhIs</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Butterweck, V</creator><creator>Petereit, F</creator><creator>Winterhoff, H</creator><creator>Nahrstedt, A</creator><general>Thieme</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19980501</creationdate><title>Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test</title><author>Butterweck, V ; Petereit, F ; Winterhoff, H ; Nahrstedt, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f259t-b182b8446695336322c9ec93a4bff03714624c3195c2e5ba597684ce44c73f213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>activity</topic><topic>Animals</topic><topic>antidepressants</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>chemical constituents of plants</topic><topic>fractionation</topic><topic>General pharmacology</topic><topic>Hypericum perforatum</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicinal properties</topic><topic>metabolites</topic><topic>naphthodianthrones</topic><topic>neuropharmacology</topic><topic>Perylene - analogs & derivatives</topic><topic>Perylene - chemistry</topic><topic>Perylene - therapeutic use</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>procyanidins</topic><topic>Rats</topic><topic>Solubility</topic><topic>Stress, Psychological - drug therapy</topic><topic>Swimming</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Butterweck, V</creatorcontrib><creatorcontrib>Petereit, F</creatorcontrib><creatorcontrib>Winterhoff, H</creatorcontrib><creatorcontrib>Nahrstedt, A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Butterweck, V</au><au>Petereit, F</au><au>Winterhoff, H</au><au>Nahrstedt, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>64</volume><issue>4</issue><spage>291</spage><epage>294</epage><pages>291-294</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>It has been shown recently that the fraction IIIc of a crude extract of Hypericum perforatum, (St. John's wort) that contained both hypericin (1) and pseudohypericin (2), was remarkably active in the rats forced swimming test (FST) after Porsolt. However, neither of the naphthodianthrones isolated from this fraction were sufficiently effective when administered suspended in water. The solubility of 1 and 2 is remarkably increased in the presence of a fraction containing procyanidins, especially procyanidin B2, which is present also in the active Hypericum fraction IIIc. The cooperative effect of procyanidins significantly increased the in vivo effects of 1 and 2, which exhibited inverted U-shaped dose response curves, in the FST. The anti-immobility effect of solubilized 1 and 2 was antagonized by the dopamine antagonist sulpiride. These data indicate that naphthodianthrones are antidepressant constituents of H. perforatum and suggest that the dopaminergic system is involved in their action.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>9619107</pmid><doi>10.1055/s-2006-957437</doi><tpages>4</tpages></addata></record> |
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| ispartof | Planta medica, 1998-05, Vol.64 (4), p.291-294 |
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| language | eng |
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| subjects | activity Animals antidepressants Antidepressive Agents - therapeutic use Biological and medical sciences chemical constituents of plants fractionation General pharmacology Hypericum perforatum Male Medical sciences medicinal properties metabolites naphthodianthrones neuropharmacology Perylene - analogs & derivatives Perylene - chemistry Perylene - therapeutic use Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments procyanidins Rats Solubility Stress, Psychological - drug therapy Swimming |
| title | Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test |
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