Potent and Selective Stimulation of Memory-Phenotype CD8 + T Cells In Vivo by IL-15
Proliferation of memory-phenotype (CD44 hi) CD8 + cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I–inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent. Sin...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 1998-05, Vol.8 (5), p.591-599 |
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| container_title | Immunity (Cambridge, Mass.) |
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| creator | Zhang, Xiaohong Sun, Siquan Hwang, Inkyu Tough, David F Sprent, Jonathan |
| description | Proliferation of memory-phenotype (CD44
hi) CD8
+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I–inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent. Since IFN I inhibits proliferation in vitro, IFN I–induced proliferation of CD8
+ cells in vivo presumably occurs indirectly through production of secondary cytokines, e.g., interleukin-2 (IL-2) or IL-15. We show here that, unlike IL-2, IL-15 closely mimics the effects of IFN I in causing strong and selective stimulation of memory-phenotype CD44
hi CD8
+ (but not CD4
+) cells in vivo; similar specificity applies to purified T cells in vitro and correlates with much higher expression of IL-2Rβ on CD8
+ cells than on CD4
+ cells. |
| doi_str_mv | 10.1016/S1074-7613(00)80564-6 |
| format | Article |
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+ cells in vivo presumably occurs indirectly through production of secondary cytokines, e.g., interleukin-2 (IL-2) or IL-15. We show here that, unlike IL-2, IL-15 closely mimics the effects of IFN I in causing strong and selective stimulation of memory-phenotype CD44
hi CD8
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hi) CD8
+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I–inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent. Since IFN I inhibits proliferation in vitro, IFN I–induced proliferation of CD8
+ cells in vivo presumably occurs indirectly through production of secondary cytokines, e.g., interleukin-2 (IL-2) or IL-15. We show here that, unlike IL-2, IL-15 closely mimics the effects of IFN I in causing strong and selective stimulation of memory-phenotype CD44
hi CD8
+ (but not CD4
+) cells in vivo; similar specificity applies to purified T cells in vitro and correlates with much higher expression of IL-2Rβ on CD8
+ cells than on CD4
+ cells.</description><subject>AIDS/HIV</subject><subject>Animals</subject><subject>CD8-Positive T-Lymphocytes - drug effects</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Cell Division - drug effects</subject><subject>Cells, Cultured</subject><subject>Hyaluronan Receptors - analysis</subject><subject>Immunologic Memory</subject><subject>Interferon Type I - pharmacology</subject><subject>Interleukin-15 - biosynthesis</subject><subject>Interleukin-15 - pharmacology</subject><subject>Interleukin-2 - pharmacology</subject><subject>Kinetics</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Phenotype</subject><subject>Poly I-C - pharmacology</subject><subject>Receptors, Interleukin-2 - analysis</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtLAzEQhYMoWqs_QciTKLI62UuyeRJZb4WKhaqvIZvMYmR3UzfbQv-9W1t89WkGzpmZMx8hZwyuGTB-M2cg0khwllwAXOaQ8TTie2TEQIooZTnsb_qd5Ygch_AFwNJMwiE5lDwGnsOIzGe-x7anurV0jjWa3q2QznvXLGvdO99SX9EXbHy3jmaf2Pp-vUBa3Of0ir7RAus60ElLP9zK03JNJ9OIZSfkoNJ1wNNdHZP3x4e34jmavj5NirtpZIYUfRRrK1KWyCxOUHKbYiVsxoYeDJdGpDbRlREsSfIqljbTJeRaGIMllIybBJMxOd_uXXT-e4mhV40LZoikW_TLoISUscjSeDBmW6PpfAgdVmrRuUZ3a8VAbWCqX5hqQ0oBqF-Yig9zZ7sDy7JB-ze1ozfot1sdhy9XDjsVjMPWoHXdQFJZ7_658ANw5IHA</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Zhang, Xiaohong</creator><creator>Sun, Siquan</creator><creator>Hwang, Inkyu</creator><creator>Tough, David F</creator><creator>Sprent, Jonathan</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980501</creationdate><title>Potent and Selective Stimulation of Memory-Phenotype CD8 + T Cells In Vivo by IL-15</title><author>Zhang, Xiaohong ; Sun, Siquan ; Hwang, Inkyu ; Tough, David F ; Sprent, Jonathan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-2ad74139523e96d4ef7d513e90c69c74d3afc71338f29d5ab08a7cceb0b16c3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>AIDS/HIV</topic><topic>Animals</topic><topic>CD8-Positive T-Lymphocytes - drug effects</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Cell Division - drug effects</topic><topic>Cells, Cultured</topic><topic>Hyaluronan Receptors - analysis</topic><topic>Immunologic Memory</topic><topic>Interferon Type I - pharmacology</topic><topic>Interleukin-15 - biosynthesis</topic><topic>Interleukin-15 - pharmacology</topic><topic>Interleukin-2 - pharmacology</topic><topic>Kinetics</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Phenotype</topic><topic>Poly I-C - pharmacology</topic><topic>Receptors, Interleukin-2 - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xiaohong</creatorcontrib><creatorcontrib>Sun, Siquan</creatorcontrib><creatorcontrib>Hwang, Inkyu</creatorcontrib><creatorcontrib>Tough, David F</creatorcontrib><creatorcontrib>Sprent, Jonathan</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunity (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xiaohong</au><au>Sun, Siquan</au><au>Hwang, Inkyu</au><au>Tough, David F</au><au>Sprent, Jonathan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potent and Selective Stimulation of Memory-Phenotype CD8 + T Cells In Vivo by IL-15</atitle><jtitle>Immunity (Cambridge, Mass.)</jtitle><addtitle>Immunity</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>8</volume><issue>5</issue><spage>591</spage><epage>599</epage><pages>591-599</pages><issn>1074-7613</issn><eissn>1097-4180</eissn><abstract>Proliferation of memory-phenotype (CD44
hi) CD8
+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I–inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent. Since IFN I inhibits proliferation in vitro, IFN I–induced proliferation of CD8
+ cells in vivo presumably occurs indirectly through production of secondary cytokines, e.g., interleukin-2 (IL-2) or IL-15. We show here that, unlike IL-2, IL-15 closely mimics the effects of IFN I in causing strong and selective stimulation of memory-phenotype CD44
hi CD8
+ (but not CD4
+) cells in vivo; similar specificity applies to purified T cells in vitro and correlates with much higher expression of IL-2Rβ on CD8
+ cells than on CD4
+ cells.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9620680</pmid><doi>10.1016/S1074-7613(00)80564-6</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Immunity (Cambridge, Mass.), 1998-05, Vol.8 (5), p.591-599 |
| issn | 1074-7613 1097-4180 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; EZB-FREE-00999 freely available EZB journals |
| subjects | AIDS/HIV Animals CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Division - drug effects Cells, Cultured Hyaluronan Receptors - analysis Immunologic Memory Interferon Type I - pharmacology Interleukin-15 - biosynthesis Interleukin-15 - pharmacology Interleukin-2 - pharmacology Kinetics Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - metabolism Mice Mice, Inbred C57BL Phenotype Poly I-C - pharmacology Receptors, Interleukin-2 - analysis |
| title | Potent and Selective Stimulation of Memory-Phenotype CD8 + T Cells In Vivo by IL-15 |
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