Tumor necrosis factor-like cytotoxicity and anorexia in Ascaris suum infected pigs
Tumor Necrosis Factor-Like Cytotoxicity (TNF-LC) was examined in sera from 12 pigs experimentally infected with Ascaris suum. The difference of TNF-LC levels between eight infected and four uninfected controls was not significant. When an endotoxin challenge was intravenously administered 1 month af...
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| Veröffentlicht in: | Veterinary parasitology 1990-05, Vol.36 (1), p.37-44 |
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| creator | Yang, S. Bottoms, G.D. Gaafar, S.M. |
| description | Tumor Necrosis Factor-Like Cytotoxicity (TNF-LC) was examined in sera from 12 pigs experimentally infected with
Ascaris suum. The difference of TNF-LC levels between eight infected and four uninfected controls was not significant. When an endotoxin challenge was intravenously administered 1 month after the first dose of
A. suum, the levels of TNF-LC in the sera of infected pigs were one-third that of the controls 125 min post-challenge (PC). In a more detailed study on four infected and two uninfected control pigs, TNF-LC was monitored every 10–15 min until 125 min after endotoxin challenge. The TNF-LC levels in these pigs increased at 40 min PC, reached maximum in another 10–25 min and then decreased. This pattern was seen in all except one infected pig. The infected pigs showed milder shock symptoms and their serum TNF-LC levels returned to pre-challenge levels 30 min earlier than controls. |
| doi_str_mv | 10.1016/0304-4017(90)90092-P |
| format | Article |
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Ascaris suum. The difference of TNF-LC levels between eight infected and four uninfected controls was not significant. When an endotoxin challenge was intravenously administered 1 month after the first dose of
A. suum, the levels of TNF-LC in the sera of infected pigs were one-third that of the controls 125 min post-challenge (PC). In a more detailed study on four infected and two uninfected control pigs, TNF-LC was monitored every 10–15 min until 125 min after endotoxin challenge. The TNF-LC levels in these pigs increased at 40 min PC, reached maximum in another 10–25 min and then decreased. This pattern was seen in all except one infected pig. The infected pigs showed milder shock symptoms and their serum TNF-LC levels returned to pre-challenge levels 30 min earlier than controls.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/0304-4017(90)90092-P</identifier><identifier>PMID: 2382388</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Anorexia - etiology ; Anorexia - veterinary ; Ascariasis - blood ; Ascariasis - complications ; Ascariasis - veterinary ; Cell Adhesion - drug effects ; Dactinomycin - pharmacology ; Feeding and Eating Disorders - veterinary ; Female ; Male ; Swine ; Swine Diseases - blood ; Swine Diseases - etiology ; Tumor Necrosis Factor-alpha - analysis</subject><ispartof>Veterinary parasitology, 1990-05, Vol.36 (1), p.37-44</ispartof><rights>1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-9221992f300d26feb2c280ee7089650cfc033c4a169ba6bc314db1c24000221c3</citedby><cites>FETCH-LOGICAL-c357t-9221992f300d26feb2c280ee7089650cfc033c4a169ba6bc314db1c24000221c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/030440179090092P$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2382388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, S.</creatorcontrib><creatorcontrib>Bottoms, G.D.</creatorcontrib><creatorcontrib>Gaafar, S.M.</creatorcontrib><title>Tumor necrosis factor-like cytotoxicity and anorexia in Ascaris suum infected pigs</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>Tumor Necrosis Factor-Like Cytotoxicity (TNF-LC) was examined in sera from 12 pigs experimentally infected with
Ascaris suum. The difference of TNF-LC levels between eight infected and four uninfected controls was not significant. When an endotoxin challenge was intravenously administered 1 month after the first dose of
A. suum, the levels of TNF-LC in the sera of infected pigs were one-third that of the controls 125 min post-challenge (PC). In a more detailed study on four infected and two uninfected control pigs, TNF-LC was monitored every 10–15 min until 125 min after endotoxin challenge. The TNF-LC levels in these pigs increased at 40 min PC, reached maximum in another 10–25 min and then decreased. This pattern was seen in all except one infected pig. The infected pigs showed milder shock symptoms and their serum TNF-LC levels returned to pre-challenge levels 30 min earlier than controls.</description><subject>Animals</subject><subject>Anorexia - etiology</subject><subject>Anorexia - veterinary</subject><subject>Ascariasis - blood</subject><subject>Ascariasis - complications</subject><subject>Ascariasis - veterinary</subject><subject>Cell Adhesion - drug effects</subject><subject>Dactinomycin - pharmacology</subject><subject>Feeding and Eating Disorders - veterinary</subject><subject>Female</subject><subject>Male</subject><subject>Swine</subject><subject>Swine Diseases - blood</subject><subject>Swine Diseases - etiology</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFtLxDAQhYMoul7-gUKfRB-qk8u2zYsg4g0ERfQ5pNOpRLfNmrTi_nuz7uKjkBDCnHOG8zF2yOGMAy_OQYLKFfDyRMOpBtAif9pgE16VMhfTKWyyyZ9kh-3G-A4ACopym20LWaVTTdjzy9j5kPWEwUcXs9bi4EM-cx-U4WLwg_926IZFZvsmXR_o29nM9dllRBuSIY5jl_4t4UBNNndvcZ9ttXYW6WD97rHXm-uXq7v84fH2_uryIUc5LYdcC8G1Fq0EaETRUi1QVEBUQqWLKWCLICUqywtd26JGyVVTcxQqtUhWlHvseJU7D_5zpDiYzkWk2cz25MdoypReKq6SUK2Ey44xUGvmwXU2LAwHs0RplpzMkpPRYH5RmqdkO1rnj3VHzZ9pzS7NL1ZzSiW_HAUT0VGP1LiQaJjGu_8X_ABxPIK8</recordid><startdate>19900501</startdate><enddate>19900501</enddate><creator>Yang, S.</creator><creator>Bottoms, G.D.</creator><creator>Gaafar, S.M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900501</creationdate><title>Tumor necrosis factor-like cytotoxicity and anorexia in Ascaris suum infected pigs</title><author>Yang, S. ; Bottoms, G.D. ; Gaafar, S.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-9221992f300d26feb2c280ee7089650cfc033c4a169ba6bc314db1c24000221c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Anorexia - etiology</topic><topic>Anorexia - veterinary</topic><topic>Ascariasis - blood</topic><topic>Ascariasis - complications</topic><topic>Ascariasis - veterinary</topic><topic>Cell Adhesion - drug effects</topic><topic>Dactinomycin - pharmacology</topic><topic>Feeding and Eating Disorders - veterinary</topic><topic>Female</topic><topic>Male</topic><topic>Swine</topic><topic>Swine Diseases - blood</topic><topic>Swine Diseases - etiology</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, S.</creatorcontrib><creatorcontrib>Bottoms, G.D.</creatorcontrib><creatorcontrib>Gaafar, S.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, S.</au><au>Bottoms, G.D.</au><au>Gaafar, S.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor necrosis factor-like cytotoxicity and anorexia in Ascaris suum infected pigs</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>1990-05-01</date><risdate>1990</risdate><volume>36</volume><issue>1</issue><spage>37</spage><epage>44</epage><pages>37-44</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>Tumor Necrosis Factor-Like Cytotoxicity (TNF-LC) was examined in sera from 12 pigs experimentally infected with
Ascaris suum. The difference of TNF-LC levels between eight infected and four uninfected controls was not significant. When an endotoxin challenge was intravenously administered 1 month after the first dose of
A. suum, the levels of TNF-LC in the sera of infected pigs were one-third that of the controls 125 min post-challenge (PC). In a more detailed study on four infected and two uninfected control pigs, TNF-LC was monitored every 10–15 min until 125 min after endotoxin challenge. The TNF-LC levels in these pigs increased at 40 min PC, reached maximum in another 10–25 min and then decreased. This pattern was seen in all except one infected pig. The infected pigs showed milder shock symptoms and their serum TNF-LC levels returned to pre-challenge levels 30 min earlier than controls.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>2382388</pmid><doi>10.1016/0304-4017(90)90092-P</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-4017 |
| ispartof | Veterinary parasitology, 1990-05, Vol.36 (1), p.37-44 |
| issn | 0304-4017 1873-2550 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anorexia - etiology Anorexia - veterinary Ascariasis - blood Ascariasis - complications Ascariasis - veterinary Cell Adhesion - drug effects Dactinomycin - pharmacology Feeding and Eating Disorders - veterinary Female Male Swine Swine Diseases - blood Swine Diseases - etiology Tumor Necrosis Factor-alpha - analysis |
| title | Tumor necrosis factor-like cytotoxicity and anorexia in Ascaris suum infected pigs |
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