Fibrin Glue as a Hemostatic Agent in Hepatic and Splenic Trauma
Fibrin glue is a biologic hemostatic agent that coagulates and seals upon application. It is made by combining human fibrinogen concentrate with standard thrombin solutions containing calcium. Similar to epoxy glue, the two components are applied simultaneously in equal volumes resulting in an almos...
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| Veröffentlicht in: | The Journal of trauma 1990-07, Vol.30 (7), p.884-887 |
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| container_title | The Journal of trauma |
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| creator | OCHSNER, M. GAGE MANISCALCO-THEBERGE, MARY E. CHAMPION, HOWARD R. |
| description | Fibrin glue is a biologic hemostatic agent that coagulates and seals upon application. It is made by combining human fibrinogen concentrate with standard thrombin solutions containing calcium. Similar to epoxy glue, the two components are applied simultaneously in equal volumes resulting in an almost instantaneous formation of a coagulum. Fibrinogen concentrate is prepared in the blood bank from single donor plasma. Fibrin glue can be applied topically or injected into the parenchyma of solid organs.Twenty-six patients sustained hepatic or splenic trauma from May through August 1989–17 liver and nine splenic injuries. The glue was effective after one application in 21 patients and after a second in five. Hemostasis was achieved despite coagulopathy and thrombocytopenia in eight patients. There were no re-explorations for bleeding, and nine complications occurred in six patients.Our experience suggests fibrin glue is an effective, underutilized adjunctive hemostatic agent in trauma. |
| doi_str_mv | 10.1097/00005373-199007000-00020 |
| format | Article |
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GAGE ; MANISCALCO-THEBERGE, MARY E. ; CHAMPION, HOWARD R.</creator><creatorcontrib>OCHSNER, M. GAGE ; MANISCALCO-THEBERGE, MARY E. ; CHAMPION, HOWARD R.</creatorcontrib><description>Fibrin glue is a biologic hemostatic agent that coagulates and seals upon application. It is made by combining human fibrinogen concentrate with standard thrombin solutions containing calcium. Similar to epoxy glue, the two components are applied simultaneously in equal volumes resulting in an almost instantaneous formation of a coagulum. Fibrinogen concentrate is prepared in the blood bank from single donor plasma. Fibrin glue can be applied topically or injected into the parenchyma of solid organs.Twenty-six patients sustained hepatic or splenic trauma from May through August 1989–17 liver and nine splenic injuries. The glue was effective after one application in 21 patients and after a second in five. Hemostasis was achieved despite coagulopathy and thrombocytopenia in eight patients. There were no re-explorations for bleeding, and nine complications occurred in six patients.Our experience suggests fibrin glue is an effective, underutilized adjunctive hemostatic agent in trauma.</description><identifier>ISSN: 0022-5282</identifier><identifier>EISSN: 1529-8809</identifier><identifier>DOI: 10.1097/00005373-199007000-00020</identifier><identifier>PMID: 2381006</identifier><identifier>CODEN: JOTRA5</identifier><language>eng</language><publisher>Baltimore, MD: Williams & Wilkins</publisher><subject>Biological and medical sciences ; Fibrin Tissue Adhesive - therapeutic use ; Humans ; Injuries of the abdomen. Foreign bodies of the digestive system ; Liver - injuries ; Medical sciences ; Spleen - injuries ; Traumas. 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The glue was effective after one application in 21 patients and after a second in five. Hemostasis was achieved despite coagulopathy and thrombocytopenia in eight patients. There were no re-explorations for bleeding, and nine complications occurred in six patients.Our experience suggests fibrin glue is an effective, underutilized adjunctive hemostatic agent in trauma.</description><subject>Biological and medical sciences</subject><subject>Fibrin Tissue Adhesive - therapeutic use</subject><subject>Humans</subject><subject>Injuries of the abdomen. Foreign bodies of the digestive system</subject><subject>Liver - injuries</subject><subject>Medical sciences</subject><subject>Spleen - injuries</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Wounds, Nonpenetrating - complications</subject><subject>Wounds, Nonpenetrating - therapy</subject><subject>Wounds, Penetrating - complications</subject><subject>Wounds, Penetrating - therapy</subject><issn>0022-5282</issn><issn>1529-8809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1PAyEQhonR1Fr9CSZc9LbKx1LgZJrGtiZNPFjPhN0Fu8p-CLtp_Pdiu9aTJBOYeZ8ZyAsAEKM7jCS_R3ExymmCpUSIxyyJQdAJGGNGZCIEkqdgHEskYUSQc3ARwntE0pSKERgRKjBC0zF4WJSZL2u4dL2BOkANV6ZqQqe7MoezN1N3MKor0-4Lui7gS-tMHc8br_tKX4Izq10wV8M-Aa-Lx818layfl0_z2TrJU4ZRgg3GOkulNNSmFutpRoiwU2Fx1DnGAuWEY84Jz6jErNCWMSk55UXORJFmdAJuD3Nb33z2JnSqKkNunNO1afqguJSESSQiKA5g7psQvLGq9WWl_ZfCSP14p369U0fv1N672Ho93NFnlSmOjYNZUb8ZdB1y7azXdV6Gv_nxBVwgHrn0wO0a1xkfPly_M15tjXbdVv33dfQbSvmDEg</recordid><startdate>199007</startdate><enddate>199007</enddate><creator>OCHSNER, M. 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GAGE</creatorcontrib><creatorcontrib>MANISCALCO-THEBERGE, MARY E.</creatorcontrib><creatorcontrib>CHAMPION, HOWARD R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of trauma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OCHSNER, M. GAGE</au><au>MANISCALCO-THEBERGE, MARY E.</au><au>CHAMPION, HOWARD R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibrin Glue as a Hemostatic Agent in Hepatic and Splenic Trauma</atitle><jtitle>The Journal of trauma</jtitle><addtitle>J Trauma</addtitle><date>1990-07</date><risdate>1990</risdate><volume>30</volume><issue>7</issue><spage>884</spage><epage>887</epage><pages>884-887</pages><issn>0022-5282</issn><eissn>1529-8809</eissn><coden>JOTRA5</coden><abstract>Fibrin glue is a biologic hemostatic agent that coagulates and seals upon application. It is made by combining human fibrinogen concentrate with standard thrombin solutions containing calcium. Similar to epoxy glue, the two components are applied simultaneously in equal volumes resulting in an almost instantaneous formation of a coagulum. Fibrinogen concentrate is prepared in the blood bank from single donor plasma. Fibrin glue can be applied topically or injected into the parenchyma of solid organs.Twenty-six patients sustained hepatic or splenic trauma from May through August 1989–17 liver and nine splenic injuries. The glue was effective after one application in 21 patients and after a second in five. Hemostasis was achieved despite coagulopathy and thrombocytopenia in eight patients. There were no re-explorations for bleeding, and nine complications occurred in six patients.Our experience suggests fibrin glue is an effective, underutilized adjunctive hemostatic agent in trauma.</abstract><cop>Baltimore, MD</cop><pub>Williams & Wilkins</pub><pmid>2381006</pmid><doi>10.1097/00005373-199007000-00020</doi><tpages>4</tpages></addata></record> |
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| ispartof | The Journal of trauma, 1990-07, Vol.30 (7), p.884-887 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biological and medical sciences Fibrin Tissue Adhesive - therapeutic use Humans Injuries of the abdomen. Foreign bodies of the digestive system Liver - injuries Medical sciences Spleen - injuries Traumas. Diseases due to physical agents Wounds, Nonpenetrating - complications Wounds, Nonpenetrating - therapy Wounds, Penetrating - complications Wounds, Penetrating - therapy |
| title | Fibrin Glue as a Hemostatic Agent in Hepatic and Splenic Trauma |
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