Synthesis of Dipeptide-Type Human Immunodeficiency Virus (HIV) Protease Inhibitors with a Binding Unit to GP120

Some dipeptide-type human immunodeficiency virus (HIV) protease inhibitors derived from KNI-102, with a N-carbomethoxycarbonylprolyl-phenylalanine benzyl ester (CPF) moiety as a binding site to gp120, were synthesized. Compounds 11a showed 7-100 times higher HIV protease-inhibitory activity (11a; IC...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1998/05/15, Vol.46(5), pp.867-870
Hauptverfasser:	ASAGARASU, Akira, TAKAYANAGI, Nao, ACHIWA, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Chromatography, High Pressure Liquid CPF gp120 HIV HIV Envelope Protein gp120 - metabolism HIV Protease Inhibitors - chemical synthesis HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - metabolism Humans hybrid compound Magnetic Resonance Spectroscopy Medical sciences Oligopeptides - chemistry Pharmacology. Drug treatments Phenylalanine - analogs & derivatives Phenylalanine - chemical synthesis Phenylalanine - chemistry Phenylalanine - metabolism protease inhibitor Protein Binding Spectrophotometry, Infrared
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