Inhibition of Leukocyte Function by Serum from Patients with Trichinellosis
Modification of leukocytic function has been reported in only a few human parasitic diseases. In this study we evaluated the effects of the sera from patients infected with Trichinella on chemotactic and phagocytic responses in leukocytes. Leukocyte chemotaxis was tested by the agarose method and ph...
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| Veröffentlicht in: | The Journal of parasitology 1990-08, Vol.76 (4), p.577-579 |
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| container_title | The Journal of parasitology |
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| creator | Bruschi, F. Pozio, E. Carulli, G. Polidori, R. Azzara, A. |
| description | Modification of leukocytic function has been reported in only a few human parasitic diseases. In this study we evaluated the effects of the sera from patients infected with Trichinella on chemotactic and phagocytic responses in leukocytes. Leukocyte chemotaxis was tested by the agarose method and phagocytosis by the technique of Yamamura, modified for Saccharomyces cerevisiae. Sera were acquired from patients during a trichinellosis outbreak that occurred in northern Italy in 1986. The parasite was isolated from 1 patient and isoenzymatically typed as Trichinella sp. 3, a new taxon, previously considered Trichinella nelsoni. The results indicated that sera from Trichinella-infected humans inhibited both chemotaxic and phagocytic responses in leukocytes. These findings suggest the existence of serum factor(s) in trichinellosis patients that modify host leukocytic functions. The source and nature of active serum components and the mechanism by which they modulate leukocyte function remain to be clarified. |
| doi_str_mv | 10.2307/3282845 |
| format | Article |
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In this study we evaluated the effects of the sera from patients infected with Trichinella on chemotactic and phagocytic responses in leukocytes. Leukocyte chemotaxis was tested by the agarose method and phagocytosis by the technique of Yamamura, modified for Saccharomyces cerevisiae. Sera were acquired from patients during a trichinellosis outbreak that occurred in northern Italy in 1986. The parasite was isolated from 1 patient and isoenzymatically typed as Trichinella sp. 3, a new taxon, previously considered Trichinella nelsoni. The results indicated that sera from Trichinella-infected humans inhibited both chemotaxic and phagocytic responses in leukocytes. These findings suggest the existence of serum factor(s) in trichinellosis patients that modify host leukocytic functions. The source and nature of active serum components and the mechanism by which they modulate leukocyte function remain to be clarified.</description><identifier>ISSN: 0022-3395</identifier><identifier>EISSN: 1937-2345</identifier><identifier>DOI: 10.2307/3282845</identifier><identifier>PMID: 2199653</identifier><identifier>CODEN: JOPAA2</identifier><language>eng</language><publisher>Lawrence, KS: American Society of Parasitologists</publisher><subject>Biological and medical sciences ; Cell Migration Inhibition ; Chemotaxis ; Chemotaxis, Leukocyte - immunology ; Disease Outbreaks ; Eosinophils ; Female ; Fluorescent Antibody Technique ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immune Sera - immunology ; Immunobiology ; Infections ; Italy - epidemiology ; Leukocytes ; Male ; Modulation of the immune response (stimulation, suppression) ; Nematode larvae ; Nematodes ; Neutrophils ; Neutrophils - immunology ; Parasite hosts ; Parasitology ; Phagocytosis ; Phagocytosis - immunology ; Research Notes ; Snails ; Trichinellosis - epidemiology ; Trichinellosis - immunology</subject><ispartof>The Journal of parasitology, 1990-08, Vol.76 (4), p.577-579</ispartof><rights>Copyright 1990 American Society of Parasitologists</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-78c693c02139a7ae3450ba13144d16370695273998e7f25d68fec489d8847ff23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3282845$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3282845$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5067894$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2199653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bruschi, F.</creatorcontrib><creatorcontrib>Pozio, E.</creatorcontrib><creatorcontrib>Carulli, G.</creatorcontrib><creatorcontrib>Polidori, R.</creatorcontrib><creatorcontrib>Azzara, A.</creatorcontrib><title>Inhibition of Leukocyte Function by Serum from Patients with Trichinellosis</title><title>The Journal of parasitology</title><addtitle>J Parasitol</addtitle><description>Modification of leukocytic function has been reported in only a few human parasitic diseases. In this study we evaluated the effects of the sera from patients infected with Trichinella on chemotactic and phagocytic responses in leukocytes. Leukocyte chemotaxis was tested by the agarose method and phagocytosis by the technique of Yamamura, modified for Saccharomyces cerevisiae. Sera were acquired from patients during a trichinellosis outbreak that occurred in northern Italy in 1986. The parasite was isolated from 1 patient and isoenzymatically typed as Trichinella sp. 3, a new taxon, previously considered Trichinella nelsoni. The results indicated that sera from Trichinella-infected humans inhibited both chemotaxic and phagocytic responses in leukocytes. These findings suggest the existence of serum factor(s) in trichinellosis patients that modify host leukocytic functions. The source and nature of active serum components and the mechanism by which they modulate leukocyte function remain to be clarified.</description><subject>Biological and medical sciences</subject><subject>Cell Migration Inhibition</subject><subject>Chemotaxis</subject><subject>Chemotaxis, Leukocyte - immunology</subject><subject>Disease Outbreaks</subject><subject>Eosinophils</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immune Sera - immunology</subject><subject>Immunobiology</subject><subject>Infections</subject><subject>Italy - epidemiology</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Modulation of the immune response (stimulation, suppression)</subject><subject>Nematode larvae</subject><subject>Nematodes</subject><subject>Neutrophils</subject><subject>Neutrophils - immunology</subject><subject>Parasite hosts</subject><subject>Parasitology</subject><subject>Phagocytosis</subject><subject>Phagocytosis - immunology</subject><subject>Research Notes</subject><subject>Snails</subject><subject>Trichinellosis - epidemiology</subject><subject>Trichinellosis - immunology</subject><issn>0022-3395</issn><issn>1937-2345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMotX7gLxByED2t5mOzSY5SrBYLCtbzks0mNLW7qUkW6b93tUs9eRgG5n2YeecF4AKjW0IRv6NEEJGzAzDGkvKM0JwdgjFChGSUSnYMTmJcIYRYXyMwIljKgtExeJ61S1e55HwLvYVz0314vU0GTrtW_06rLXwzoWugDb6Bryo506YIv1xawkVweulas1776OIZOLJqHc350E_B-_RhMXnK5i-Ps8n9PNOU5injQheSakQwlYor01tFlcIU53mNC8pRIRnhVEphuCWsLoQ1OheyFiLn1hJ6Cq53ezfBf3YmprJxUfcmVGt8F0suJWH9hz14swN18DEGY8tNcI0K2xKj8ie2coitJy-HlV3VmHrPDTn1-tWgq6jV2gbVahf3GEMFFzL_w1Yx-fDvtW8emH2B</recordid><startdate>19900801</startdate><enddate>19900801</enddate><creator>Bruschi, F.</creator><creator>Pozio, E.</creator><creator>Carulli, G.</creator><creator>Polidori, R.</creator><creator>Azzara, A.</creator><general>American Society of Parasitologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900801</creationdate><title>Inhibition of Leukocyte Function by Serum from Patients with Trichinellosis</title><author>Bruschi, F. ; Pozio, E. ; Carulli, G. ; Polidori, R. ; Azzara, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-78c693c02139a7ae3450ba13144d16370695273998e7f25d68fec489d8847ff23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Biological and medical sciences</topic><topic>Cell Migration Inhibition</topic><topic>Chemotaxis</topic><topic>Chemotaxis, Leukocyte - immunology</topic><topic>Disease Outbreaks</topic><topic>Eosinophils</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immune Sera - immunology</topic><topic>Immunobiology</topic><topic>Infections</topic><topic>Italy - epidemiology</topic><topic>Leukocytes</topic><topic>Male</topic><topic>Modulation of the immune response (stimulation, suppression)</topic><topic>Nematode larvae</topic><topic>Nematodes</topic><topic>Neutrophils</topic><topic>Neutrophils - immunology</topic><topic>Parasite hosts</topic><topic>Parasitology</topic><topic>Phagocytosis</topic><topic>Phagocytosis - immunology</topic><topic>Research Notes</topic><topic>Snails</topic><topic>Trichinellosis - epidemiology</topic><topic>Trichinellosis - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bruschi, F.</creatorcontrib><creatorcontrib>Pozio, E.</creatorcontrib><creatorcontrib>Carulli, G.</creatorcontrib><creatorcontrib>Polidori, R.</creatorcontrib><creatorcontrib>Azzara, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bruschi, F.</au><au>Pozio, E.</au><au>Carulli, G.</au><au>Polidori, R.</au><au>Azzara, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Leukocyte Function by Serum from Patients with Trichinellosis</atitle><jtitle>The Journal of parasitology</jtitle><addtitle>J Parasitol</addtitle><date>1990-08-01</date><risdate>1990</risdate><volume>76</volume><issue>4</issue><spage>577</spage><epage>579</epage><pages>577-579</pages><issn>0022-3395</issn><eissn>1937-2345</eissn><coden>JOPAA2</coden><abstract>Modification of leukocytic function has been reported in only a few human parasitic diseases. In this study we evaluated the effects of the sera from patients infected with Trichinella on chemotactic and phagocytic responses in leukocytes. Leukocyte chemotaxis was tested by the agarose method and phagocytosis by the technique of Yamamura, modified for Saccharomyces cerevisiae. Sera were acquired from patients during a trichinellosis outbreak that occurred in northern Italy in 1986. The parasite was isolated from 1 patient and isoenzymatically typed as Trichinella sp. 3, a new taxon, previously considered Trichinella nelsoni. The results indicated that sera from Trichinella-infected humans inhibited both chemotaxic and phagocytic responses in leukocytes. These findings suggest the existence of serum factor(s) in trichinellosis patients that modify host leukocytic functions. The source and nature of active serum components and the mechanism by which they modulate leukocyte function remain to be clarified.</abstract><cop>Lawrence, KS</cop><pub>American Society of Parasitologists</pub><pmid>2199653</pmid><doi>10.2307/3282845</doi><tpages>3</tpages></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Biological and medical sciences Cell Migration Inhibition Chemotaxis Chemotaxis, Leukocyte - immunology Disease Outbreaks Eosinophils Female Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immune Sera - immunology Immunobiology Infections Italy - epidemiology Leukocytes Male Modulation of the immune response (stimulation, suppression) Nematode larvae Nematodes Neutrophils Neutrophils - immunology Parasite hosts Parasitology Phagocytosis Phagocytosis - immunology Research Notes Snails Trichinellosis - epidemiology Trichinellosis - immunology |
| title | Inhibition of Leukocyte Function by Serum from Patients with Trichinellosis |
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