Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases

The recent discovery that brain PGP 9.5 is a ubiquitin carboxyl‐terminal hydrolase suggests that the role of this protein should be studied in relation to ubiquitinated cellular inclusions characteristic of several chronic human degenerative diseases. Formalin‐fixed, paraffin‐processed sections know...

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Veröffentlicht in:	The Journal of pathology 1990-06, Vol.161 (2), p.153-160
Hauptverfasser:	Lowe, James, McDermott, Helen, Landon, Michael, Mayer, R. John, Wilkinson, Keith D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - enzymology Alzheimer's disease Astrocytoma - enzymology Biological and medical sciences Brain Diseases - enzymology cellular proteolysis Cerebellar Neoplasms - enzymology dementia Dementia - enzymology diffuse Lewy body disease heat shock protein Humans Inclusion Bodies - enzymology inclusion body Medical sciences motor neurone disease Motor Neurons Neurology Neuromuscular Diseases - enzymology Neuropeptides - analysis Parkinson's disease PGP 9.5 Thiolester Hydrolases - analysis Ubiquitin ubiquitin C-terminal hydrolase Ubiquitin Thiolesterase Ubiquitin, PGP 9.5
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