Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-kappaB activation

Liver transplantation is the only therapeutic strategy for many inherited and acquired diseases. The formation of reactive oxygen species following ischemia/reperfusion is a cause of hepatocellular injury during transplantation. This report describes the therapeutic application of mitochondrial supe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature medicine 1998-06, Vol.4 (6), p.698-704
Hauptverfasser:	Zwacka, R M, Zhou, W, Zhang, Y, Darby, C J, Dudus, L, Halldorson, J, Oberley, L, Engelhardt, J F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Gene Expression - genetics Genetic Therapy Liver - blood supply Liver - enzymology Male Mice Mice, Nude Mitochondria, Liver - chemistry Mitochondria, Liver - enzymology Mitochondria, Liver - genetics NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Oxidation-Reduction Proto-Oncogene Proteins - metabolism Recombinant Proteins - genetics Reperfusion Injury - genetics Reperfusion Injury - therapy Superoxide Dismutase - analysis Superoxide Dismutase - genetics Superoxide Dismutase - physiology Transcription Factor AP-1 - antagonists & inhibitors Transcription Factor AP-1 - metabolism Transcription Factor RelB Transcription Factors Transcriptional Activation - genetics Transcriptional Activation - physiology Transgenes - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!