The genetically programmed down-regulation of lactase in children

Background & Aims: Intestinal lactase activity is high in all healthy human babies, but in adults a genetic polymorphism, which acts in cis to the lactase gene, determines high or low messenger RNA (mRNA) expression and activity (lactase persistence and nonpersistence, respectively). Our aim was...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1998-06, Vol.114 (6), p.1230-1236
Hauptverfasser:	Wang, Yangxi, Harvey, Clare B., Hollox, Edward J., Phillips, Alan D., Poulter, Mark, Clay, Peter, Walker-Smith, John A., Swallow, Dallas M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alleles beta-Galactosidase - genetics Biological and medical sciences Biopsy Carbohydrates Child Child Development - physiology Child, Preschool Fetus - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Humans Infant Infant, Newborn Intestines - enzymology Intestines - pathology Lactase Metabolisms and neurohumoral controls Polymorphism, Genetic - physiology Prospective Studies Reference Values Retrospective Studies RNA, Messenger - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
Online-Zugang:	Volltext
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