RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles. Here we show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, de...

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Veröffentlicht in:	Nature (London) 1998-05, Vol.393 (6683), p.333-339
Hauptverfasser:	McLatchie, Linda M., Fraser, Neil J., Main, Martin J., Wise, Alan, Brown, Jason, Thompson, Nicola, Solari, Roberto, Lee, Melanie G., Foord, Steven M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adrenomedullin Amino Acid Sequence Animals Biological and medical sciences Biological Transport Calcitonin - chemistry Calcitonin - metabolism Calcitonin Gene-Related Peptide - genetics Calcitonin Gene-Related Peptide - metabolism Calcitonin Receptor-Like Protein Cell Line Cell receptors Cell structures and functions Cloning, Molecular Cross-Linking Reagents Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Glycosylation Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humanities and Social Sciences Humans Intracellular Signaling Peptides and Proteins Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mice Molecular and cellular biology Molecular Sequence Data multidisciplinary Neurology Peptides Peptides - metabolism Proteins Receptor Activity-Modifying Protein 1 Receptor Activity-Modifying Protein 2 Receptor Activity-Modifying Proteins Receptors, Adrenomedullin Receptors, Calcitonin - metabolism Receptors, Calcitonin Gene-Related Peptide - genetics Receptors, Calcitonin Gene-Related Peptide - metabolism Receptors, Peptide RNA, Messenger - metabolism Science Science (multidisciplinary) Sequence Alignment Tumor Cells, Cultured Xenopus
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