Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer
Background & Aims: Reports in the literature regarding the relationship of Helicobacter pylori infection to gastric cancer are conflicting. The aim of this study was to identify the source of heterogeneity between studies. Methods: Meta-analysis of cohort or case-control studies with age- and/or...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1998-06, Vol.114 (6), p.1169-1179 |
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| creator | Huang, Jia-Qing Sridhar, Subbaramiah Chen, Ying Hunt, Richard H. |
| description | Background & Aims: Reports in the literature regarding the relationship of
Helicobacter pylori infection to gastric cancer are conflicting. The aim of this study was to identify the source of heterogeneity between studies.
Methods: Meta-analysis of cohort or case-control studies with age- and/or sex-matched controls, providing raw data on
H. pylori infection detected by serology, was used.
Results: A fully recursive literature search identified 19 qualified studies with 2491 patients and 3959 controls. Test for homogeneity found a significant difference in odds ratio between patients with early and advanced gastric cancer (6.35 vs. 2.13;
P = 0.01), patients with cardiac and noncardiac gastric cancer (1.23 vs. 3.08;
P = 0.003), and population- and hospital-based controls (2.11 vs. 1.49;
P < 0.001). The summary odds ratio for gastric cancer in
H. pylori–infected patients is 1.92 (95% confidence interval [CI], 1.32–2.78), 2.24 (95% CI, 1.15–4.4), and 1.81 (95% CI, 1.16–2.84) for all studies, cohort, and case-control studies, respectively.
H. pylori–infected younger patients have a higher relative risk for gastric cancer than older patients with odds ratios decreasing from 9.29 at age ≤29 years to 1.05 at age ≥70 years.
H. pylori infection is equally associated with the intestinal or diffuse type of gastric cancer.
Conclusions:
H. pylori infection is a risk factor for gastric cancer. The heterogeneity of reported results is caused by differences in the selection of controls, patient age, and the site and stage of gastric cancer.
GASTROENTEROLOGY 1998;114:1169-1179 |
| doi_str_mv | 10.1016/S0016-5085(98)70422-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79921931</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0016508598704226</els_id><sourcerecordid>79921931</sourcerecordid><originalsourceid>FETCH-LOGICAL-c507t-34598d7868e9f5decedcba9c454ba5e23e56b7c1103fa75141de6762e5fa23d23</originalsourceid><addsrcrecordid>eNqFkMFu1DAQhi1UVJbCI1TyAVVwCNhO7MQnhCqgSEUcWs7WxJ60rrJx8HgX7duT7a72ymV8-L_fY3-MXUrxUQppPt2JZVZadPq97T60olGqMi_YSmrVVUumztjqhLxir4mehBC27uQ5O7dG2FbXK-Z-YoEKJhh3FImngZdH5BlHKDFN9Bhn3mP5izjxGxyjTz34gpnPuzHlyAlzmhPFErex7DhMgT8AlRw99zB5zG_YywFGwrfH84L9_vb1_vqmuv31_cf1l9vKa9GWqm607ULbmQ7toAN6DL4H6xvd9KBR1ahN33opRT1Aq2UjA5rWKNQDqDqo-oJdHe6dc_qzQSpuHcnjOMKEaUOutVZJW8sF1AfQ50SUcXBzjmvIOyeF24t1z2Ld3pqznXsW68zSuzwu2PRrDKfW0eSSvzvmQB7GIS_fj3TClNLKyD32-YDhImMbMTvyERdTIWb0xYUU__OQf9GIln8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79921931</pqid></control><display><type>article</type><title>Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Alma/SFX Local Collection</source><creator>Huang, Jia-Qing ; Sridhar, Subbaramiah ; Chen, Ying ; Hunt, Richard H.</creator><creatorcontrib>Huang, Jia-Qing ; Sridhar, Subbaramiah ; Chen, Ying ; Hunt, Richard H.</creatorcontrib><description>Background & Aims: Reports in the literature regarding the relationship of
Helicobacter pylori infection to gastric cancer are conflicting. The aim of this study was to identify the source of heterogeneity between studies.
Methods: Meta-analysis of cohort or case-control studies with age- and/or sex-matched controls, providing raw data on
H. pylori infection detected by serology, was used.
Results: A fully recursive literature search identified 19 qualified studies with 2491 patients and 3959 controls. Test for homogeneity found a significant difference in odds ratio between patients with early and advanced gastric cancer (6.35 vs. 2.13;
P = 0.01), patients with cardiac and noncardiac gastric cancer (1.23 vs. 3.08;
P = 0.003), and population- and hospital-based controls (2.11 vs. 1.49;
P < 0.001). The summary odds ratio for gastric cancer in
H. pylori–infected patients is 1.92 (95% confidence interval [CI], 1.32–2.78), 2.24 (95% CI, 1.15–4.4), and 1.81 (95% CI, 1.16–2.84) for all studies, cohort, and case-control studies, respectively.
H. pylori–infected younger patients have a higher relative risk for gastric cancer than older patients with odds ratios decreasing from 9.29 at age ≤29 years to 1.05 at age ≥70 years.
H. pylori infection is equally associated with the intestinal or diffuse type of gastric cancer.
Conclusions:
H. pylori infection is a risk factor for gastric cancer. The heterogeneity of reported results is caused by differences in the selection of controls, patient age, and the site and stage of gastric cancer.
GASTROENTEROLOGY 1998;114:1169-1179</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/S0016-5085(98)70422-6</identifier><identifier>PMID: 9609753</identifier><identifier>CODEN: GASTAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aging - physiology ; Antibodies, Bacterial - analysis ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Case-Control Studies ; Cohort Studies ; Helicobacter Infections - complications ; Helicobacter Infections - diagnosis ; Helicobacter pylori - immunology ; Human bacterial diseases ; Humans ; Infectious diseases ; Medical sciences ; Odds Ratio ; Risk Factors ; Serologic Tests ; Stomach Neoplasms - microbiology</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1998-06, Vol.114 (6), p.1169-1179</ispartof><rights>1998 American Gastroenterological Association</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-34598d7868e9f5decedcba9c454ba5e23e56b7c1103fa75141de6762e5fa23d23</citedby><cites>FETCH-LOGICAL-c507t-34598d7868e9f5decedcba9c454ba5e23e56b7c1103fa75141de6762e5fa23d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0016508598704226$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2252613$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9609753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Jia-Qing</creatorcontrib><creatorcontrib>Sridhar, Subbaramiah</creatorcontrib><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Hunt, Richard H.</creatorcontrib><title>Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>Background & Aims: Reports in the literature regarding the relationship of
Helicobacter pylori infection to gastric cancer are conflicting. The aim of this study was to identify the source of heterogeneity between studies.
Methods: Meta-analysis of cohort or case-control studies with age- and/or sex-matched controls, providing raw data on
H. pylori infection detected by serology, was used.
Results: A fully recursive literature search identified 19 qualified studies with 2491 patients and 3959 controls. Test for homogeneity found a significant difference in odds ratio between patients with early and advanced gastric cancer (6.35 vs. 2.13;
P = 0.01), patients with cardiac and noncardiac gastric cancer (1.23 vs. 3.08;
P = 0.003), and population- and hospital-based controls (2.11 vs. 1.49;
P < 0.001). The summary odds ratio for gastric cancer in
H. pylori–infected patients is 1.92 (95% confidence interval [CI], 1.32–2.78), 2.24 (95% CI, 1.15–4.4), and 1.81 (95% CI, 1.16–2.84) for all studies, cohort, and case-control studies, respectively.
H. pylori–infected younger patients have a higher relative risk for gastric cancer than older patients with odds ratios decreasing from 9.29 at age ≤29 years to 1.05 at age ≥70 years.
H. pylori infection is equally associated with the intestinal or diffuse type of gastric cancer.
Conclusions:
H. pylori infection is a risk factor for gastric cancer. The heterogeneity of reported results is caused by differences in the selection of controls, patient age, and the site and stage of gastric cancer.
GASTROENTEROLOGY 1998;114:1169-1179</description><subject>Aging - physiology</subject><subject>Antibodies, Bacterial - analysis</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - diagnosis</subject><subject>Helicobacter pylori - immunology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Odds Ratio</subject><subject>Risk Factors</subject><subject>Serologic Tests</subject><subject>Stomach Neoplasms - microbiology</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFu1DAQhi1UVJbCI1TyAVVwCNhO7MQnhCqgSEUcWs7WxJ60rrJx8HgX7duT7a72ymV8-L_fY3-MXUrxUQppPt2JZVZadPq97T60olGqMi_YSmrVVUumztjqhLxir4mehBC27uQ5O7dG2FbXK-Z-YoEKJhh3FImngZdH5BlHKDFN9Bhn3mP5izjxGxyjTz34gpnPuzHlyAlzmhPFErex7DhMgT8AlRw99zB5zG_YywFGwrfH84L9_vb1_vqmuv31_cf1l9vKa9GWqm607ULbmQ7toAN6DL4H6xvd9KBR1ahN33opRT1Aq2UjA5rWKNQDqDqo-oJdHe6dc_qzQSpuHcnjOMKEaUOutVZJW8sF1AfQ50SUcXBzjmvIOyeF24t1z2Ld3pqznXsW68zSuzwu2PRrDKfW0eSSvzvmQB7GIS_fj3TClNLKyD32-YDhImMbMTvyERdTIWb0xYUU__OQf9GIln8</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>Huang, Jia-Qing</creator><creator>Sridhar, Subbaramiah</creator><creator>Chen, Ying</creator><creator>Hunt, Richard H.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980601</creationdate><title>Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer</title><author>Huang, Jia-Qing ; Sridhar, Subbaramiah ; Chen, Ying ; Hunt, Richard H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-34598d7868e9f5decedcba9c454ba5e23e56b7c1103fa75141de6762e5fa23d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aging - physiology</topic><topic>Antibodies, Bacterial - analysis</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - diagnosis</topic><topic>Helicobacter pylori - immunology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Odds Ratio</topic><topic>Risk Factors</topic><topic>Serologic Tests</topic><topic>Stomach Neoplasms - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Jia-Qing</creatorcontrib><creatorcontrib>Sridhar, Subbaramiah</creatorcontrib><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Hunt, Richard H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Jia-Qing</au><au>Sridhar, Subbaramiah</au><au>Chen, Ying</au><au>Hunt, Richard H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1998-06-01</date><risdate>1998</risdate><volume>114</volume><issue>6</issue><spage>1169</spage><epage>1179</epage><pages>1169-1179</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>Background & Aims: Reports in the literature regarding the relationship of
Helicobacter pylori infection to gastric cancer are conflicting. The aim of this study was to identify the source of heterogeneity between studies.
Methods: Meta-analysis of cohort or case-control studies with age- and/or sex-matched controls, providing raw data on
H. pylori infection detected by serology, was used.
Results: A fully recursive literature search identified 19 qualified studies with 2491 patients and 3959 controls. Test for homogeneity found a significant difference in odds ratio between patients with early and advanced gastric cancer (6.35 vs. 2.13;
P = 0.01), patients with cardiac and noncardiac gastric cancer (1.23 vs. 3.08;
P = 0.003), and population- and hospital-based controls (2.11 vs. 1.49;
P < 0.001). The summary odds ratio for gastric cancer in
H. pylori–infected patients is 1.92 (95% confidence interval [CI], 1.32–2.78), 2.24 (95% CI, 1.15–4.4), and 1.81 (95% CI, 1.16–2.84) for all studies, cohort, and case-control studies, respectively.
H. pylori–infected younger patients have a higher relative risk for gastric cancer than older patients with odds ratios decreasing from 9.29 at age ≤29 years to 1.05 at age ≥70 years.
H. pylori infection is equally associated with the intestinal or diffuse type of gastric cancer.
Conclusions:
H. pylori infection is a risk factor for gastric cancer. The heterogeneity of reported results is caused by differences in the selection of controls, patient age, and the site and stage of gastric cancer.
GASTROENTEROLOGY 1998;114:1169-1179</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9609753</pmid><doi>10.1016/S0016-5085(98)70422-6</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Alma/SFX Local Collection |
| subjects | Aging - physiology Antibodies, Bacterial - analysis Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Case-Control Studies Cohort Studies Helicobacter Infections - complications Helicobacter Infections - diagnosis Helicobacter pylori - immunology Human bacterial diseases Humans Infectious diseases Medical sciences Odds Ratio Risk Factors Serologic Tests Stomach Neoplasms - microbiology |
| title | Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer |
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