Caucasian versus African-American Differences in Orosomucoid: Potential Implications for Therapy
We conducted a prospective, nonrandomized study in healthy volunteers to determine if racial differences exist in orosomucoid (ORM) and its variants, and to examine quinidine and lidocaine binding to the protein. Total ORM serum concentrations were measured by Laurell‐Rocket immunoelectrophoresis. A...
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| Veröffentlicht in: | Pharmacotherapy 1998-05, Vol.18 (3), p.620-626 |
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| creator | McCollam, Patrick L. Crouch, Michael A. Arnaud, Philippe |
| description | We conducted a prospective, nonrandomized study in healthy volunteers to determine if racial differences exist in orosomucoid (ORM) and its variants, and to examine quinidine and lidocaine binding to the protein. Total ORM serum concentrations were measured by Laurell‐Rocket immunoelectrophoresis. Allele types were determined by isoelectric focusing and immunoblotting. Total and unbound quinidine and lidocaine concentrations were measured with standard fluorescence polarization immunoassays after ultrafiltration. The frequency of the common ORM alleles was similar between 38 Caucasians and 67 African‐Americans. Mean total ORM concentration was significantly lower in Caucasians (57.3 ± 25.4 vs 73.2 ± 33.9 mg/dl, p=0.01). However, more Caucasians took oral contraceptives, which may have decreased ORM concentrations. Quinidine unbound fraction (UF) was related to ORM phenotype. The highest UF was found with ORM 1‐S (p=0.009). There were no significant relationships between ORM phenotype and lidocaine UF Overall, African‐Americans had higher ORM concentrations than Caucasians. Quinidine binding showed significant relationships to specific ORM variants. |
| doi_str_mv | 10.1002/j.1875-9114.1998.tb03125.x |
| format | Article |
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Total ORM serum concentrations were measured by Laurell‐Rocket immunoelectrophoresis. Allele types were determined by isoelectric focusing and immunoblotting. Total and unbound quinidine and lidocaine concentrations were measured with standard fluorescence polarization immunoassays after ultrafiltration. The frequency of the common ORM alleles was similar between 38 Caucasians and 67 African‐Americans. Mean total ORM concentration was significantly lower in Caucasians (57.3 ± 25.4 vs 73.2 ± 33.9 mg/dl, p=0.01). However, more Caucasians took oral contraceptives, which may have decreased ORM concentrations. Quinidine unbound fraction (UF) was related to ORM phenotype. The highest UF was found with ORM 1‐S (p=0.009). There were no significant relationships between ORM phenotype and lidocaine UF Overall, African‐Americans had higher ORM concentrations than Caucasians. Quinidine binding showed significant relationships to specific ORM variants.</description><identifier>ISSN: 0277-0008</identifier><identifier>EISSN: 1875-9114</identifier><identifier>DOI: 10.1002/j.1875-9114.1998.tb03125.x</identifier><identifier>PMID: 9620113</identifier><identifier>CODEN: PHPYDQ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Alleles ; Biological and medical sciences ; Black or African American ; Black People - genetics ; Blotting, Western ; Female ; Fluorescence Polarization Immunoassay ; General pharmacology ; Humans ; Immunoelectrophoresis ; Isoelectric Focusing ; Lidocaine - blood ; Male ; Medical sciences ; Middle Aged ; Orosomucoid - genetics ; Orosomucoid - metabolism ; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions ; Pharmacology. Drug treatments ; Phenotype ; Prospective Studies ; Protein Binding ; Quinidine - blood ; White People - genetics</subject><ispartof>Pharmacotherapy, 1998-05, Vol.18 (3), p.620-626</ispartof><rights>1998 Pharmacotherapy Publications Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4385-5ae74fadb476b3512319195f42755b99e5a7bd39ee3520477732c7e083e6c4233</citedby><cites>FETCH-LOGICAL-c4385-5ae74fadb476b3512319195f42755b99e5a7bd39ee3520477732c7e083e6c4233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fj.1875-9114.1998.tb03125.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fj.1875-9114.1998.tb03125.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2326084$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9620113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McCollam, Patrick L.</creatorcontrib><creatorcontrib>Crouch, Michael A.</creatorcontrib><creatorcontrib>Arnaud, Philippe</creatorcontrib><title>Caucasian versus African-American Differences in Orosomucoid: Potential Implications for Therapy</title><title>Pharmacotherapy</title><addtitle>Pharmacotherapy</addtitle><description>We conducted a prospective, nonrandomized study in healthy volunteers to determine if racial differences exist in orosomucoid (ORM) and its variants, and to examine quinidine and lidocaine binding to the protein. Total ORM serum concentrations were measured by Laurell‐Rocket immunoelectrophoresis. Allele types were determined by isoelectric focusing and immunoblotting. Total and unbound quinidine and lidocaine concentrations were measured with standard fluorescence polarization immunoassays after ultrafiltration. The frequency of the common ORM alleles was similar between 38 Caucasians and 67 African‐Americans. Mean total ORM concentration was significantly lower in Caucasians (57.3 ± 25.4 vs 73.2 ± 33.9 mg/dl, p=0.01). However, more Caucasians took oral contraceptives, which may have decreased ORM concentrations. Quinidine unbound fraction (UF) was related to ORM phenotype. The highest UF was found with ORM 1‐S (p=0.009). There were no significant relationships between ORM phenotype and lidocaine UF Overall, African‐Americans had higher ORM concentrations than Caucasians. Quinidine binding showed significant relationships to specific ORM variants.</description><subject>Adult</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Black or African American</subject><subject>Black People - genetics</subject><subject>Blotting, Western</subject><subject>Female</subject><subject>Fluorescence Polarization Immunoassay</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Immunoelectrophoresis</subject><subject>Isoelectric Focusing</subject><subject>Lidocaine - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Orosomucoid - genetics</subject><subject>Orosomucoid - metabolism</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenotype</subject><subject>Prospective Studies</subject><subject>Protein Binding</subject><subject>Quinidine - blood</subject><subject>White People - genetics</subject><issn>0277-0008</issn><issn>1875-9114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1v0zAUhi0EGmXwE5AshLhL8Gcc74qqwDZUbdM0Pu6M4x4Ll3wUO4H235PQqPdc-UjneV_bD0KvKMkpIeztNqelkpmmVORU6zLvK8Ipk_n-EVqcVo_RgjClMkJI-RQ9S2k7Zmkh2Bk60wUjlPIF-r6yg7Mp2Bb_hpiGhJc-BmfbbNnAvwG_D95DhNZBwqHFt7FLXTO4Lmwu8F3XQ9sHW-PrZlePeB-6NmHfRfzwA6LdHZ6jJ97WCV7M5zn6_PHDw-oqW99eXq-W68wJXspMWlDC200lVFFxSRmnmmrpBVNSVlqDtKracA3AJSNCKcWZU0BKDoUTjPNz9ObYu4vdrwFSb5qQHNS1baEbklFaM6rJBF4cQTd-JEXwZhdDY-PBUGImvWZrJodmcmgmvWbWa_Zj-OV8y1A1sDlFZ5_j_vW8t8nZ2kfbupBOGOOsIKUYsXdH7E-o4fAfDzB3V8v7aRwrsmNFSD3sTxU2_jSF4mP6682luf8iebH-9snc8L_XVaas</recordid><startdate>199805</startdate><enddate>199805</enddate><creator>McCollam, Patrick L.</creator><creator>Crouch, Michael A.</creator><creator>Arnaud, Philippe</creator><general>Blackwell Publishing Ltd</general><general>Pharmacotherapy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199805</creationdate><title>Caucasian versus African-American Differences in Orosomucoid: Potential Implications for Therapy</title><author>McCollam, Patrick L. ; Crouch, Michael A. ; Arnaud, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4385-5ae74fadb476b3512319195f42755b99e5a7bd39ee3520477732c7e083e6c4233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Black or African American</topic><topic>Black People - genetics</topic><topic>Blotting, Western</topic><topic>Female</topic><topic>Fluorescence Polarization Immunoassay</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Immunoelectrophoresis</topic><topic>Isoelectric Focusing</topic><topic>Lidocaine - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Orosomucoid - genetics</topic><topic>Orosomucoid - metabolism</topic><topic>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenotype</topic><topic>Prospective Studies</topic><topic>Protein Binding</topic><topic>Quinidine - blood</topic><topic>White People - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCollam, Patrick L.</creatorcontrib><creatorcontrib>Crouch, Michael A.</creatorcontrib><creatorcontrib>Arnaud, Philippe</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCollam, Patrick L.</au><au>Crouch, Michael A.</au><au>Arnaud, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caucasian versus African-American Differences in Orosomucoid: Potential Implications for Therapy</atitle><jtitle>Pharmacotherapy</jtitle><addtitle>Pharmacotherapy</addtitle><date>1998-05</date><risdate>1998</risdate><volume>18</volume><issue>3</issue><spage>620</spage><epage>626</epage><pages>620-626</pages><issn>0277-0008</issn><eissn>1875-9114</eissn><coden>PHPYDQ</coden><abstract>We conducted a prospective, nonrandomized study in healthy volunteers to determine if racial differences exist in orosomucoid (ORM) and its variants, and to examine quinidine and lidocaine binding to the protein. Total ORM serum concentrations were measured by Laurell‐Rocket immunoelectrophoresis. Allele types were determined by isoelectric focusing and immunoblotting. Total and unbound quinidine and lidocaine concentrations were measured with standard fluorescence polarization immunoassays after ultrafiltration. The frequency of the common ORM alleles was similar between 38 Caucasians and 67 African‐Americans. Mean total ORM concentration was significantly lower in Caucasians (57.3 ± 25.4 vs 73.2 ± 33.9 mg/dl, p=0.01). However, more Caucasians took oral contraceptives, which may have decreased ORM concentrations. Quinidine unbound fraction (UF) was related to ORM phenotype. The highest UF was found with ORM 1‐S (p=0.009). There were no significant relationships between ORM phenotype and lidocaine UF Overall, African‐Americans had higher ORM concentrations than Caucasians. Quinidine binding showed significant relationships to specific ORM variants.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9620113</pmid><doi>10.1002/j.1875-9114.1998.tb03125.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Alleles Biological and medical sciences Black or African American Black People - genetics Blotting, Western Female Fluorescence Polarization Immunoassay General pharmacology Humans Immunoelectrophoresis Isoelectric Focusing Lidocaine - blood Male Medical sciences Middle Aged Orosomucoid - genetics Orosomucoid - metabolism Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Phenotype Prospective Studies Protein Binding Quinidine - blood White People - genetics |
| title | Caucasian versus African-American Differences in Orosomucoid: Potential Implications for Therapy |
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