Effects of drug therapy on Toxoplasma cysts in an animal model of acute and chronic disease
To evaluate the effects of drug therapy on the clinical course of acute acquired Toxoplasma retinochoroiditis and on the number of Toxoplasma cysts present in the brain and ocular tissues in the hamster animal model. The Syrian golden hamster animal model of Toxoplasma retinochoroiditis was used. In...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 1998-06, Vol.39 (7), p.1171-1175 |
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| creator | Gormley, PD Pavesio, CE Minnasian, D Lightman, S |
| description | To evaluate the effects of drug therapy on the clinical course of acute acquired Toxoplasma retinochoroiditis and on the number of Toxoplasma cysts present in the brain and ocular tissues in the hamster animal model.
The Syrian golden hamster animal model of Toxoplasma retinochoroiditis was used. In acute disease, systemically administered atovaquone was compared with conventional therapies (pyrimethamine combined with sulfadiazine; clindamycin; and spiramycin). The clinical course of the ocular disease was determined with retinal examination and photography of the fundus. The number of Toxoplasma cysts remaining after treatment was evaluated in aliquots of brain homogenate and in retinal tissue. The effect of atovaquone on cerebral Toxoplasma cyst count was also studied in chronic disease.
None of the drugs administered altered the course of the acute disease, judged by clinical examination. Atovaquone alone significantly reduced the number of cerebral Toxoplasma cysts after acute disease. Atovaquone also significantly reduced the cerebral Toxoplasma cyst count in chronic disease.
Tissue cysts are believed to be responsible for reactivation of Toxoplasma retinochoroiditis. Atovaquone has the potential to reduce the risk of recurrent disease. |
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The Syrian golden hamster animal model of Toxoplasma retinochoroiditis was used. In acute disease, systemically administered atovaquone was compared with conventional therapies (pyrimethamine combined with sulfadiazine; clindamycin; and spiramycin). The clinical course of the ocular disease was determined with retinal examination and photography of the fundus. The number of Toxoplasma cysts remaining after treatment was evaluated in aliquots of brain homogenate and in retinal tissue. The effect of atovaquone on cerebral Toxoplasma cyst count was also studied in chronic disease.
None of the drugs administered altered the course of the acute disease, judged by clinical examination. Atovaquone alone significantly reduced the number of cerebral Toxoplasma cysts after acute disease. Atovaquone also significantly reduced the cerebral Toxoplasma cyst count in chronic disease.
Tissue cysts are believed to be responsible for reactivation of Toxoplasma retinochoroiditis. Atovaquone has the potential to reduce the risk of recurrent disease.</description><identifier>ISSN: 0146-0404</identifier><identifier>EISSN: 1552-5783</identifier><identifier>PMID: 9620076</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Acute Disease ; Animals ; Anti-Bacterial Agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiparasitic agents ; Antiprotozoal Agents - pharmacology ; Atovaquone ; Biological and medical sciences ; Brain - parasitology ; Chorioretinitis - drug therapy ; Chorioretinitis - parasitology ; Chorioretinitis - pathology ; Chronic Disease ; Cricetinae ; Disease Models, Animal ; Drug Therapy, Combination - pharmacology ; Female ; Medical sciences ; Mesocricetus ; Naphthoquinones - pharmacology ; Pharmacology. Drug treatments ; Retina - parasitology ; Toxoplasma - isolation & purification ; Toxoplasmosis, Cerebral - drug therapy ; Toxoplasmosis, Cerebral - parasitology ; Toxoplasmosis, Cerebral - pathology ; Toxoplasmosis, Ocular - drug therapy ; Toxoplasmosis, Ocular - parasitology ; Toxoplasmosis, Ocular - pathology</subject><ispartof>Investigative ophthalmology & visual science, 1998-06, Vol.39 (7), p.1171-1175</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2256308$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9620076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gormley, PD</creatorcontrib><creatorcontrib>Pavesio, CE</creatorcontrib><creatorcontrib>Minnasian, D</creatorcontrib><creatorcontrib>Lightman, S</creatorcontrib><title>Effects of drug therapy on Toxoplasma cysts in an animal model of acute and chronic disease</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>To evaluate the effects of drug therapy on the clinical course of acute acquired Toxoplasma retinochoroiditis and on the number of Toxoplasma cysts present in the brain and ocular tissues in the hamster animal model.
The Syrian golden hamster animal model of Toxoplasma retinochoroiditis was used. In acute disease, systemically administered atovaquone was compared with conventional therapies (pyrimethamine combined with sulfadiazine; clindamycin; and spiramycin). The clinical course of the ocular disease was determined with retinal examination and photography of the fundus. The number of Toxoplasma cysts remaining after treatment was evaluated in aliquots of brain homogenate and in retinal tissue. The effect of atovaquone on cerebral Toxoplasma cyst count was also studied in chronic disease.
None of the drugs administered altered the course of the acute disease, judged by clinical examination. Atovaquone alone significantly reduced the number of cerebral Toxoplasma cysts after acute disease. Atovaquone also significantly reduced the cerebral Toxoplasma cyst count in chronic disease.
Tissue cysts are believed to be responsible for reactivation of Toxoplasma retinochoroiditis. Atovaquone has the potential to reduce the risk of recurrent disease.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Anti-Bacterial Agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiparasitic agents</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Atovaquone</subject><subject>Biological and medical sciences</subject><subject>Brain - parasitology</subject><subject>Chorioretinitis - drug therapy</subject><subject>Chorioretinitis - parasitology</subject><subject>Chorioretinitis - pathology</subject><subject>Chronic Disease</subject><subject>Cricetinae</subject><subject>Disease Models, Animal</subject><subject>Drug Therapy, Combination - pharmacology</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Mesocricetus</subject><subject>Naphthoquinones - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Retina - parasitology</subject><subject>Toxoplasma - isolation & purification</subject><subject>Toxoplasmosis, Cerebral - drug therapy</subject><subject>Toxoplasmosis, Cerebral - parasitology</subject><subject>Toxoplasmosis, Cerebral - pathology</subject><subject>Toxoplasmosis, Ocular - drug therapy</subject><subject>Toxoplasmosis, Ocular - parasitology</subject><subject>Toxoplasmosis, Ocular - pathology</subject><issn>0146-0404</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAQhoMo67r6E4QcxFshSdukPcqyfoDgZT15CNN8bCtpU5OWuv_eLhaFgYF5n3mHec_QmuY5S3JRpOdoTWjGE5KR7BJdxfhJCKOUkRValZwRIvgafeysNWqI2Fusw3jAQ20C9EfsO7z33753EFvA6hhnpukwnKppweHWa-NOa6DGwcxTjVUdfNcorJtoIJprdGHBRXOz9A16f9ztt8_J69vTy_bhNakZ50MCpBLMUMhAEyis0lozACUgIyrlrBSCUKsKnVXKcJtXQHlhCNOVSDVknKcbdP_r2wf_NZo4yLaJyjgHnfFjlKIsGRUsm8HbBRyr1mjZh_mTcJRLGrN-t-gQFTgboFNN_MMYy3lKiv97dXOopyYYOUfk3GxK5TRNaSmFpFTQ9ActOnc3</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>Gormley, PD</creator><creator>Pavesio, CE</creator><creator>Minnasian, D</creator><creator>Lightman, S</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19980601</creationdate><title>Effects of drug therapy on Toxoplasma cysts in an animal model of acute and chronic disease</title><author>Gormley, PD ; Pavesio, CE ; Minnasian, D ; Lightman, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h266t-a0b72e1a4ad0a8fcddd2aac7a40c36297701fc8d4bce6f5ba168e02db73da4663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Anti-Bacterial Agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiparasitic agents</topic><topic>Antiprotozoal Agents - pharmacology</topic><topic>Atovaquone</topic><topic>Biological and medical sciences</topic><topic>Brain - parasitology</topic><topic>Chorioretinitis - drug therapy</topic><topic>Chorioretinitis - parasitology</topic><topic>Chorioretinitis - pathology</topic><topic>Chronic Disease</topic><topic>Cricetinae</topic><topic>Disease Models, Animal</topic><topic>Drug Therapy, Combination - pharmacology</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Mesocricetus</topic><topic>Naphthoquinones - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Retina - parasitology</topic><topic>Toxoplasma - isolation & purification</topic><topic>Toxoplasmosis, Cerebral - drug therapy</topic><topic>Toxoplasmosis, Cerebral - parasitology</topic><topic>Toxoplasmosis, Cerebral - pathology</topic><topic>Toxoplasmosis, Ocular - drug therapy</topic><topic>Toxoplasmosis, Ocular - parasitology</topic><topic>Toxoplasmosis, Ocular - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gormley, PD</creatorcontrib><creatorcontrib>Pavesio, CE</creatorcontrib><creatorcontrib>Minnasian, D</creatorcontrib><creatorcontrib>Lightman, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gormley, PD</au><au>Pavesio, CE</au><au>Minnasian, D</au><au>Lightman, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of drug therapy on Toxoplasma cysts in an animal model of acute and chronic disease</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>1998-06-01</date><risdate>1998</risdate><volume>39</volume><issue>7</issue><spage>1171</spage><epage>1175</epage><pages>1171-1175</pages><issn>0146-0404</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>To evaluate the effects of drug therapy on the clinical course of acute acquired Toxoplasma retinochoroiditis and on the number of Toxoplasma cysts present in the brain and ocular tissues in the hamster animal model.
The Syrian golden hamster animal model of Toxoplasma retinochoroiditis was used. In acute disease, systemically administered atovaquone was compared with conventional therapies (pyrimethamine combined with sulfadiazine; clindamycin; and spiramycin). The clinical course of the ocular disease was determined with retinal examination and photography of the fundus. The number of Toxoplasma cysts remaining after treatment was evaluated in aliquots of brain homogenate and in retinal tissue. The effect of atovaquone on cerebral Toxoplasma cyst count was also studied in chronic disease.
None of the drugs administered altered the course of the acute disease, judged by clinical examination. Atovaquone alone significantly reduced the number of cerebral Toxoplasma cysts after acute disease. Atovaquone also significantly reduced the cerebral Toxoplasma cyst count in chronic disease.
Tissue cysts are believed to be responsible for reactivation of Toxoplasma retinochoroiditis. Atovaquone has the potential to reduce the risk of recurrent disease.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>9620076</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Investigative ophthalmology & visual science, 1998-06, Vol.39 (7), p.1171-1175 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Acute Disease Animals Anti-Bacterial Agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Antiprotozoal Agents - pharmacology Atovaquone Biological and medical sciences Brain - parasitology Chorioretinitis - drug therapy Chorioretinitis - parasitology Chorioretinitis - pathology Chronic Disease Cricetinae Disease Models, Animal Drug Therapy, Combination - pharmacology Female Medical sciences Mesocricetus Naphthoquinones - pharmacology Pharmacology. Drug treatments Retina - parasitology Toxoplasma - isolation & purification Toxoplasmosis, Cerebral - drug therapy Toxoplasmosis, Cerebral - parasitology Toxoplasmosis, Cerebral - pathology Toxoplasmosis, Ocular - drug therapy Toxoplasmosis, Ocular - parasitology Toxoplasmosis, Ocular - pathology |
| title | Effects of drug therapy on Toxoplasma cysts in an animal model of acute and chronic disease |
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