CD8-positive mantle cell lymphoma : A report of two cases
Two cases of mantle cell lymphoma with a unique CD8+ phenotype are reported. Both patients had disease that was resistant to therapy; one patient had the blastic variant of mantle cell lymphoma. Flow cytometric analysis of bone marrow and cerebrospinal fluid samples revealed a phenotype consistent w...
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| Veröffentlicht in: | American journal of clinical pathology 1998-06, Vol.109 (6), p.689-694 |
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| container_title | American journal of clinical pathology |
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| creator | HOFFMANN, D. G TUCKER, S. J EMMANOULIDES, C ROSEN, P. A NAEIM, F |
| description | Two cases of mantle cell lymphoma with a unique CD8+ phenotype are reported. Both patients had disease that was resistant to therapy; one patient had the blastic variant of mantle cell lymphoma. Flow cytometric analysis of bone marrow and cerebrospinal fluid samples revealed a phenotype consistent with mantle cell lymphoma, with the additional finding of CD8 positivity in 40% or more of the tumor cells in both cases. This is the first description of such a finding, and CD8+ mantle cell lymphoma may represent a unique type of B-cell neoplasia. Our findings may be important in the prediction of therapeutic response or in the detection of residual disease after therapy. |
| doi_str_mv | 10.1093/ajcp/109.6.689 |
| format | Article |
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Our findings may be important in the prediction of therapeutic response or in the detection of residual disease after therapy.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1093/ajcp/109.6.689</identifier><identifier>PMID: 9620025</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Antigens, CD20 - analysis ; Biological and medical sciences ; Bone Marrow Cells - immunology ; CD3 Complex - analysis ; CD5 Antigens - analysis ; CD8 Antigens - analysis ; Female ; Flow Cytometry ; Fluorescein-5-isothiocyanate ; Fluorescent Dyes ; Hematologic and hematopoietic diseases ; Humans ; Immunophenotyping ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, Non-Hodgkin - cerebrospinal fluid ; Lymphoma, Non-Hodgkin - immunology ; Male ; Medical sciences ; Middle Aged ; Receptors, IgE - analysis</subject><ispartof>American journal of clinical pathology, 1998-06, Vol.109 (6), p.689-694</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-2f7cda8470d1865818737724eb9fc4649f330e371d447a0c3bb42cdad8c079c73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2250604$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9620025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HOFFMANN, D. G</creatorcontrib><creatorcontrib>TUCKER, S. J</creatorcontrib><creatorcontrib>EMMANOULIDES, C</creatorcontrib><creatorcontrib>ROSEN, P. A</creatorcontrib><creatorcontrib>NAEIM, F</creatorcontrib><title>CD8-positive mantle cell lymphoma : A report of two cases</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>Two cases of mantle cell lymphoma with a unique CD8+ phenotype are reported. Both patients had disease that was resistant to therapy; one patient had the blastic variant of mantle cell lymphoma. Flow cytometric analysis of bone marrow and cerebrospinal fluid samples revealed a phenotype consistent with mantle cell lymphoma, with the additional finding of CD8 positivity in 40% or more of the tumor cells in both cases. This is the first description of such a finding, and CD8+ mantle cell lymphoma may represent a unique type of B-cell neoplasia. Our findings may be important in the prediction of therapeutic response or in the detection of residual disease after therapy.</description><subject>Antigens, CD20 - analysis</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Cells - immunology</subject><subject>CD3 Complex - analysis</subject><subject>CD5 Antigens - analysis</subject><subject>CD8 Antigens - analysis</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Fluorescein-5-isothiocyanate</subject><subject>Fluorescent Dyes</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, Non-Hodgkin - cerebrospinal fluid</subject><subject>Lymphoma, Non-Hodgkin - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Receptors, IgE - analysis</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtLw0AYxBdRaq1evQl7EG9J95V9eCv1CQUvel42mw2mJN24myr9793Q0NM3ML8ZPgaAW4xyjBRdmq3tl0nlPOdSnYE5VoxmQhByDuYIIZIpLOgluIpxixAmErEZmClOklXMgVo_yaz3sRmaXwc7sxtaB61rW9geuv7bdwY-whUMrvdhgL6Gw5-H1kQXr8FFbdrobqa7AF8vz5_rt2zz8fq-Xm0yy0gxZKQWtjKSCVRhyQuJpaDpO-ZKVVvGmaopRY4KXDEmDLK0LBlJiUpaJJQVdAEejr198D97FwfdNXH80Oyc30ctlCKYM5LA_Aja4GMMrtZ9aDoTDhojPW6lx61GpblOW6XA3dS8LztXnfBpnOTfT76J1rR1MDvbxBNGSIE4YvQfF_lv0Q</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>HOFFMANN, D. G</creator><creator>TUCKER, S. 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A ; NAEIM, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-2f7cda8470d1865818737724eb9fc4649f330e371d447a0c3bb42cdad8c079c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Antigens, CD20 - analysis</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Cells - immunology</topic><topic>CD3 Complex - analysis</topic><topic>CD5 Antigens - analysis</topic><topic>CD8 Antigens - analysis</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Fluorescein-5-isothiocyanate</topic><topic>Fluorescent Dyes</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, Non-Hodgkin - cerebrospinal fluid</topic><topic>Lymphoma, Non-Hodgkin - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Receptors, IgE - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOFFMANN, D. G</creatorcontrib><creatorcontrib>TUCKER, S. J</creatorcontrib><creatorcontrib>EMMANOULIDES, C</creatorcontrib><creatorcontrib>ROSEN, P. 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A</au><au>NAEIM, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD8-positive mantle cell lymphoma : A report of two cases</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1998-06-01</date><risdate>1998</risdate><volume>109</volume><issue>6</issue><spage>689</spage><epage>694</epage><pages>689-694</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>Two cases of mantle cell lymphoma with a unique CD8+ phenotype are reported. Both patients had disease that was resistant to therapy; one patient had the blastic variant of mantle cell lymphoma. Flow cytometric analysis of bone marrow and cerebrospinal fluid samples revealed a phenotype consistent with mantle cell lymphoma, with the additional finding of CD8 positivity in 40% or more of the tumor cells in both cases. This is the first description of such a finding, and CD8+ mantle cell lymphoma may represent a unique type of B-cell neoplasia. Our findings may be important in the prediction of therapeutic response or in the detection of residual disease after therapy.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>9620025</pmid><doi>10.1093/ajcp/109.6.689</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of clinical pathology, 1998-06, Vol.109 (6), p.689-694 |
| issn | 0002-9173 1943-7722 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antigens, CD20 - analysis Biological and medical sciences Bone Marrow Cells - immunology CD3 Complex - analysis CD5 Antigens - analysis CD8 Antigens - analysis Female Flow Cytometry Fluorescein-5-isothiocyanate Fluorescent Dyes Hematologic and hematopoietic diseases Humans Immunophenotyping Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Non-Hodgkin - cerebrospinal fluid Lymphoma, Non-Hodgkin - immunology Male Medical sciences Middle Aged Receptors, IgE - analysis |
| title | CD8-positive mantle cell lymphoma : A report of two cases |
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