Syntheses and Antifungal Activities of dl-Griseofulvin and Its Congeners. I
dl-Griseofulvin (1a) was prepared by two synthetic pathways. New 6'-congeners (3 and 4) of griseofulvin were also prepared. Their antifungal activities were evaluated and compounds 3 and 4 were found to be less active than 1a.Molecular calculations on 1a, dl-epigriseofulvin (1b), 3 and 4 were u...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1990/04/25, Vol.38(4), pp.925-929 |
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| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 38 |
| creator | TOMOZANE, Hideo TAKEUCHI, Yasuo CHOSHI, Tominari KISHIDA, Shoko YAMATO, Masatoshi |
| description | dl-Griseofulvin (1a) was prepared by two synthetic pathways. New 6'-congeners (3 and 4) of griseofulvin were also prepared. Their antifungal activities were evaluated and compounds 3 and 4 were found to be less active than 1a.Molecular calculations on 1a, dl-epigriseofulvin (1b), 3 and 4 were undertaken. |
| doi_str_mv | 10.1248/cpb.38.925 |
| format | Article |
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I</title><author>TOMOZANE, Hideo ; TAKEUCHI, Yasuo ; CHOSHI, Tominari ; KISHIDA, Shoko ; YAMATO, Masatoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5785-77995860d83155ffe936c692a66f4dd4c7815df3a137ecee3a79853043bb9e5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>antifungal activity</topic><topic>Antifungal Agents - chemical synthesis</topic><topic>Chemistry</topic><topic>Diels-Alder reaction</topic><topic>dl-griseofulvin</topic><topic>Exact sciences and technology</topic><topic>Fungi - drug effects</topic><topic>Griseofulvin - analogs & derivatives</topic><topic>Griseofulvin - chemical synthesis</topic><topic>Griseofulvin - pharmacology</topic><topic>Heterocyclic compounds</topic><topic>Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives</topic><topic>Microbial Sensitivity Tests</topic><topic>molecular calculation</topic><topic>Organic chemistry</topic><topic>Preparations and properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TOMOZANE, Hideo</creatorcontrib><creatorcontrib>TAKEUCHI, Yasuo</creatorcontrib><creatorcontrib>CHOSHI, Tominari</creatorcontrib><creatorcontrib>KISHIDA, Shoko</creatorcontrib><creatorcontrib>YAMATO, Masatoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TOMOZANE, Hideo</au><au>TAKEUCHI, Yasuo</au><au>CHOSHI, Tominari</au><au>KISHIDA, Shoko</au><au>YAMATO, Masatoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Syntheses and Antifungal Activities of dl-Griseofulvin and Its Congeners. I</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1990</date><risdate>1990</risdate><volume>38</volume><issue>4</issue><spage>925</spage><epage>929</epage><pages>925-929</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>dl-Griseofulvin (1a) was prepared by two synthetic pathways. New 6'-congeners (3 and 4) of griseofulvin were also prepared. Their antifungal activities were evaluated and compounds 3 and 4 were found to be less active than 1a.Molecular calculations on 1a, dl-epigriseofulvin (1b), 3 and 4 were undertaken.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>2379285</pmid><doi>10.1248/cpb.38.925</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1990/04/25, Vol.38(4), pp.925-929 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79919317 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | antifungal activity Antifungal Agents - chemical synthesis Chemistry Diels-Alder reaction dl-griseofulvin Exact sciences and technology Fungi - drug effects Griseofulvin - analogs & derivatives Griseofulvin - chemical synthesis Griseofulvin - pharmacology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Microbial Sensitivity Tests molecular calculation Organic chemistry Preparations and properties |
| title | Syntheses and Antifungal Activities of dl-Griseofulvin and Its Congeners. I |
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