Antihypertensive effect of betaxolol, a cardioselective beta-adrenoceptor antagonist, in renal hypertensive dogs
The antihypertensive effect of betaxolol, a highly selective beta 1-adrenoceptor antagonist, was investigated in renal hypertensive dogs, and the mechanism was also studied. A single oral administration of betaxolol (1 and 10 mg/kg) lowered blood pressure dose-dependently. The hypotensive effect of...
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| Veröffentlicht in: | Nihon yakurigaku zasshi 1990-06, Vol.95 (6), p.355-360 |
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| container_issue | 6 |
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| container_title | Nihon yakurigaku zasshi |
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| creator | Bessho, H Suzuki, J Kitada, Y Narimatsu, A Tobe, A |
| description | The antihypertensive effect of betaxolol, a highly selective beta 1-adrenoceptor antagonist, was investigated in renal hypertensive dogs, and the mechanism was also studied. A single oral administration of betaxolol (1 and 10 mg/kg) lowered blood pressure dose-dependently. The hypotensive effect of betaxolol was enhanced by daily oral administration for 10 days. In anesthetized dogs, intraarterial injection of betaxolol produced a dose-dependent increase in femoral artery flow; and in this test, betaxolol was 3 times less potent than papaverine. The increase in blood flow with betaxolol was not affected by pretreatment with propranolol. These findings indicate that a certain vasodilating activity may contribute to the antihypertensive mechanism of betaxolol. |
| doi_str_mv | 10.1254/fpj.95.6_355 |
| format | Article |
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A single oral administration of betaxolol (1 and 10 mg/kg) lowered blood pressure dose-dependently. The hypotensive effect of betaxolol was enhanced by daily oral administration for 10 days. In anesthetized dogs, intraarterial injection of betaxolol produced a dose-dependent increase in femoral artery flow; and in this test, betaxolol was 3 times less potent than papaverine. The increase in blood flow with betaxolol was not affected by pretreatment with propranolol. 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These findings indicate that a certain vasodilating activity may contribute to the antihypertensive mechanism of betaxolol.</description><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Animals</subject><subject>Atenolol - therapeutic use</subject><subject>Betaxolol - administration & dosage</subject><subject>Betaxolol - therapeutic use</subject><subject>Blood Pressure</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Heart Rate</subject><subject>Hypertension, Renal - drug therapy</subject><subject>Hypertension, Renal - physiopathology</subject><subject>Male</subject><subject>Propranolol - therapeutic use</subject><issn>0015-5691</issn><issn>1347-8397</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkDtPwzAYRS0EKlXpxorkiakpfsR2PFaIl1SJBWbLcT6XoDQOtovg35PSSojpDvfoDAehS0qWlInyxg_vSy2W0nAhTtCU8lIVFdfqFE0JoaIQUtNzNE-prQlhFaO65BM0oVqVjOspGlZ9bt--B4gZ-tR-AgbvwWUcPK4h26_QhW6BLXY2Nm1I0I3nHtufhW0i9MHBkEPEts92E_o25QVuezw-tsP_1E3YpAt05m2XYH7cGXq9v3u5fSzWzw9Pt6t14XhFc-G8LAGAcK-YtRUVmqoGOKeCUdu4hviGaM8dcY5VypZWeilrLonSSkhf8xm6PniHGD52kLLZtslB19kewi4ZpTWtmFIjuDiALoaUIngzxHZr47ehxOwbm7Gx0cL8Nh7xq6N3V2-h-YMPRfkPcyF6tQ</recordid><startdate>19900601</startdate><enddate>19900601</enddate><creator>Bessho, H</creator><creator>Suzuki, J</creator><creator>Kitada, Y</creator><creator>Narimatsu, A</creator><creator>Tobe, A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900601</creationdate><title>Antihypertensive effect of betaxolol, a cardioselective beta-adrenoceptor antagonist, in renal hypertensive dogs</title><author>Bessho, H ; Suzuki, J ; Kitada, Y ; Narimatsu, A ; Tobe, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-cf64eee03f72aa815917de331521adcd0fd09f3c0cc287a4a6f66b36079756fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1990</creationdate><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Animals</topic><topic>Atenolol - therapeutic use</topic><topic>Betaxolol - administration & dosage</topic><topic>Betaxolol - therapeutic use</topic><topic>Blood Pressure</topic><topic>Dogs</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Heart Rate</topic><topic>Hypertension, Renal - drug therapy</topic><topic>Hypertension, Renal - physiopathology</topic><topic>Male</topic><topic>Propranolol - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bessho, H</creatorcontrib><creatorcontrib>Suzuki, J</creatorcontrib><creatorcontrib>Kitada, Y</creatorcontrib><creatorcontrib>Narimatsu, A</creatorcontrib><creatorcontrib>Tobe, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nihon yakurigaku zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bessho, H</au><au>Suzuki, J</au><au>Kitada, Y</au><au>Narimatsu, A</au><au>Tobe, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antihypertensive effect of betaxolol, a cardioselective beta-adrenoceptor antagonist, in renal hypertensive dogs</atitle><jtitle>Nihon yakurigaku zasshi</jtitle><addtitle>Nihon Yakurigaku Zasshi</addtitle><date>1990-06-01</date><risdate>1990</risdate><volume>95</volume><issue>6</issue><spage>355</spage><epage>360</epage><pages>355-360</pages><issn>0015-5691</issn><eissn>1347-8397</eissn><abstract>The antihypertensive effect of betaxolol, a highly selective beta 1-adrenoceptor antagonist, was investigated in renal hypertensive dogs, and the mechanism was also studied. 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| ispartof | Nihon yakurigaku zasshi, 1990-06, Vol.95 (6), p.355-360 |
| issn | 0015-5691 1347-8397 |
| language | jpn |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adrenergic beta-Antagonists - therapeutic use Animals Atenolol - therapeutic use Betaxolol - administration & dosage Betaxolol - therapeutic use Blood Pressure Dogs Dose-Response Relationship, Drug Female Heart Rate Hypertension, Renal - drug therapy Hypertension, Renal - physiopathology Male Propranolol - therapeutic use |
| title | Antihypertensive effect of betaxolol, a cardioselective beta-adrenoceptor antagonist, in renal hypertensive dogs |
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