Standard Breakfast Test: An Alternative to Glucagon Testing for C-Peptide Reserve?
Summary We measured C-peptide after glucagon and breakfast tests to compare the effectiveness of both tests in evaluating residual beta cell function in normal and diabetic subjects. A significantly higher C-peptide response was elicited after standard breakfast in patients with insulin-dependent di...
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| Veröffentlicht in: | Hormone and metabolic research 1990-06, Vol.22 (6), p.339-341 |
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| container_end_page | 341 |
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| container_issue | 6 |
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| container_title | Hormone and metabolic research |
| container_volume | 22 |
| creator | Escobar-Jiménez, F. Herrera Pombo, J. L. Gómez-Villalba, R. del Carril, J. Nuñez Aguilar, M. Rovira, A. |
| description | Summary
We measured C-peptide after glucagon and breakfast tests to compare the effectiveness of both tests in evaluating residual beta cell function in normal and diabetic subjects. A significantly higher C-peptide response was elicited after standard breakfast in patients with insulin-dependent diabetes mellitus of less than two years' evolution, ranging from 0.12 ± 0.07 to 0.83 ± 0.18 ng/ml (P < 0.05). In nonobese noninsulin-dependent diabetes mellitus the response ranged from 0.86 ± 0.02 to 1.89 ± 0.48 ng/ml (P < 0.0025); in obese NIDDM from 1.02 ± 0.37 to 1.55 ± 0.46 ng/ml (P < 0.05), and in normal subjects from 0.77 ± 0.23 to 2.11 ± 1.22 ng/ml (P < 0.0025). We conclude that the standard breakfast test is a useful and practical approach to the study of residual beta cell function. |
| doi_str_mv | 10.1055/s-2007-1004915 |
| format | Article |
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We measured C-peptide after glucagon and breakfast tests to compare the effectiveness of both tests in evaluating residual beta cell function in normal and diabetic subjects. A significantly higher C-peptide response was elicited after standard breakfast in patients with insulin-dependent diabetes mellitus of less than two years' evolution, ranging from 0.12 ± 0.07 to 0.83 ± 0.18 ng/ml (P < 0.05). In nonobese noninsulin-dependent diabetes mellitus the response ranged from 0.86 ± 0.02 to 1.89 ± 0.48 ng/ml (P < 0.0025); in obese NIDDM from 1.02 ± 0.37 to 1.55 ± 0.46 ng/ml (P < 0.05), and in normal subjects from 0.77 ± 0.23 to 2.11 ± 1.22 ng/ml (P < 0.0025). We conclude that the standard breakfast test is a useful and practical approach to the study of residual beta cell function.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2007-1004915</identifier><identifier>PMID: 2199364</identifier><identifier>CODEN: HMMRA2</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; C-Peptide - metabolism ; Child ; Clinical ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes Mellitus, Type 2 - metabolism ; Food, Formulated ; Fundamental and applied biological sciences. Psychology ; Glucagon - pharmacology ; Humans ; Islets of Langerhans - metabolism ; Middle Aged ; Vertebrates: endocrinology</subject><ispartof>Hormone and metabolic research, 1990-06, Vol.22 (6), p.339-341</ispartof><rights>Georg Thieme Verlag, Stuttgart · New York</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-f3fecbbccb26d9205450f92afb41cfc060923af9ffbd6fd01d17eab103025a8a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1004915.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,776,780,3004,3005,27901,27902,54534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5539034$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2199364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Escobar-Jiménez, F.</creatorcontrib><creatorcontrib>Herrera Pombo, J. L.</creatorcontrib><creatorcontrib>Gómez-Villalba, R.</creatorcontrib><creatorcontrib>del Carril, J. Nuñez</creatorcontrib><creatorcontrib>Aguilar, M.</creatorcontrib><creatorcontrib>Rovira, A.</creatorcontrib><title>Standard Breakfast Test: An Alternative to Glucagon Testing for C-Peptide Reserve?</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Summary
We measured C-peptide after glucagon and breakfast tests to compare the effectiveness of both tests in evaluating residual beta cell function in normal and diabetic subjects. A significantly higher C-peptide response was elicited after standard breakfast in patients with insulin-dependent diabetes mellitus of less than two years' evolution, ranging from 0.12 ± 0.07 to 0.83 ± 0.18 ng/ml (P < 0.05). In nonobese noninsulin-dependent diabetes mellitus the response ranged from 0.86 ± 0.02 to 1.89 ± 0.48 ng/ml (P < 0.0025); in obese NIDDM from 1.02 ± 0.37 to 1.55 ± 0.46 ng/ml (P < 0.05), and in normal subjects from 0.77 ± 0.23 to 2.11 ± 1.22 ng/ml (P < 0.0025). We conclude that the standard breakfast test is a useful and practical approach to the study of residual beta cell function.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>C-Peptide - metabolism</subject><subject>Child</subject><subject>Clinical</subject><subject>Diabetes Mellitus, Type 1 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Food, Formulated</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucagon - pharmacology</subject><subject>Humans</subject><subject>Islets of Langerhans - metabolism</subject><subject>Middle Aged</subject><subject>Vertebrates: endocrinology</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1P4zAQhi3ECgrslRuSD2hvhnEcpzUXVCq-JKRdAXu2Js4YAmlSbKfS_vtNacSN02g0z7wzehg7lnAmQevzKDKAqZAAuZF6h01krozIs1mxyyYAciY05GqfHcT4NrQDlO-xvUwao4p8wh6fErYVhopfBcJ3jzHxZ4rpgs9bPm8ShRZTvSaeOn7b9A5fuvYTqNsX7rvAF-IPrVJdEX-kSGFNl0fsh8cm0s-xHrK_N9fPizvx8Pv2fjF_EE7paRJeeXJl6VyZFZXJQOcavMnQl7l03kEBJlPojfdlVfgKZCWnhKUEBZnGGapD9mubuwrdRz-8ZJd1dNQ02FLXRzs1Rs4GegDPtqALXYyBvF2Feonhn5VgNxJttBuJdpQ4LJyMyX25pOoLH60N89NxjtFh4wO2ro5fmNbKgNpgYoul15qWZN-6frDZxO_O_gfNJodB</recordid><startdate>19900601</startdate><enddate>19900601</enddate><creator>Escobar-Jiménez, F.</creator><creator>Herrera Pombo, J. L.</creator><creator>Gómez-Villalba, R.</creator><creator>del Carril, J. Nuñez</creator><creator>Aguilar, M.</creator><creator>Rovira, A.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900601</creationdate><title>Standard Breakfast Test: An Alternative to Glucagon Testing for C-Peptide Reserve?</title><author>Escobar-Jiménez, F. ; Herrera Pombo, J. L. ; Gómez-Villalba, R. ; del Carril, J. Nuñez ; Aguilar, M. ; Rovira, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-f3fecbbccb26d9205450f92afb41cfc060923af9ffbd6fd01d17eab103025a8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>C-Peptide - metabolism</topic><topic>Child</topic><topic>Clinical</topic><topic>Diabetes Mellitus, Type 1 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Food, Formulated</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucagon - pharmacology</topic><topic>Humans</topic><topic>Islets of Langerhans - metabolism</topic><topic>Middle Aged</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Escobar-Jiménez, F.</creatorcontrib><creatorcontrib>Herrera Pombo, J. L.</creatorcontrib><creatorcontrib>Gómez-Villalba, R.</creatorcontrib><creatorcontrib>del Carril, J. Nuñez</creatorcontrib><creatorcontrib>Aguilar, M.</creatorcontrib><creatorcontrib>Rovira, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Escobar-Jiménez, F.</au><au>Herrera Pombo, J. L.</au><au>Gómez-Villalba, R.</au><au>del Carril, J. Nuñez</au><au>Aguilar, M.</au><au>Rovira, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Standard Breakfast Test: An Alternative to Glucagon Testing for C-Peptide Reserve?</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>1990-06-01</date><risdate>1990</risdate><volume>22</volume><issue>6</issue><spage>339</spage><epage>341</epage><pages>339-341</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><coden>HMMRA2</coden><abstract>Summary
We measured C-peptide after glucagon and breakfast tests to compare the effectiveness of both tests in evaluating residual beta cell function in normal and diabetic subjects. A significantly higher C-peptide response was elicited after standard breakfast in patients with insulin-dependent diabetes mellitus of less than two years' evolution, ranging from 0.12 ± 0.07 to 0.83 ± 0.18 ng/ml (P < 0.05). In nonobese noninsulin-dependent diabetes mellitus the response ranged from 0.86 ± 0.02 to 1.89 ± 0.48 ng/ml (P < 0.0025); in obese NIDDM from 1.02 ± 0.37 to 1.55 ± 0.46 ng/ml (P < 0.05), and in normal subjects from 0.77 ± 0.23 to 2.11 ± 1.22 ng/ml (P < 0.0025). We conclude that the standard breakfast test is a useful and practical approach to the study of residual beta cell function.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>2199364</pmid><doi>10.1055/s-2007-1004915</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adolescent Adult Biological and medical sciences C-Peptide - metabolism Child Clinical Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 2 - metabolism Food, Formulated Fundamental and applied biological sciences. Psychology Glucagon - pharmacology Humans Islets of Langerhans - metabolism Middle Aged Vertebrates: endocrinology |
| title | Standard Breakfast Test: An Alternative to Glucagon Testing for C-Peptide Reserve? |
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