Differentiation-specific enhancer activity in transduced keratinocytes : a model for epidermal gene therapy

HaCaT cells, a spontaneously immortalised, nontumorigenic keratinocyte line, were used as a more amenable model than primary keratinocytes for ex vivo-mediated gene transfer. These cells were transduced with retroviral vectors containing the factor IX cDNA under the control of a cytomegaloviral (CMV...

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Veröffentlicht in:	Gene therapy 1998-03, Vol.5 (3), p.394-402
Hauptverfasser:	PAGE, S. M, BROWNLEE, G. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Cell Culture Techniques Cell differentiation Cell Differentiation - genetics Cell Line Coagulation factors Culture Media, Conditioned Enhancer Elements, Genetic Enhancers Epidermis Epidermis - cytology Expression vectors Factor IX - biosynthesis Fundamental and applied biological sciences. Psychology Gene expression Gene therapy Gene Transfer Techniques Genetic Therapy Genetic Vectors Health. Pharmaceutical industry Human papillomavirus Hybrids Industrial applications and implications. Economical aspects Keratin Keratinocytes Keratinocytes - cytology Keratinocytes - metabolism Keratinocytes - transplantation Mice Mice, Nude Papillomaviridae - genetics Regulatory sequences Retroviridae - genetics Transplantation Up-Regulation
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