Characterization and complementation of a cephalosporin-deficient mutant of Streptomyces clavuligerus NRRL 3585

We have characterized a mutant of Streptomyces clavuligerus NRRL 3585 which is almost completely blocked in cephalosporin biosynthesis and exhibits depressed activities of both the delta(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) synthetase and cyclase enzymes of the cephalosporin pathway. A wi...

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Veröffentlicht in:	Applied microbiology and biotechnology 1990-02, Vol.32 (5), p.560-567
Hauptverfasser:	PIRET, J, RESENDIZ, B, MAHRO, B, JIN-YOU ZHANG, SERPE, E, ROMERO, J, CONNORS, N, DEMAIN, A. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Biology of microorganisms of confirmed or potential industrial interest Biotechnology cephalosporins Cephalosporins - biosynthesis cloning Cloning, Molecular complementation DNA DNA, Bacterial - genetics DNA, Bacterial - isolation & purification Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial - genetics Genetic Complementation Test hybridization analysis Metabolism. Enzymes Microbiology Mission oriented research mutants Mutation nucleotide sequence Oxidoreductases - genetics Peptide Synthases - genetics Phenotype Physiology and metabolism Plasmids - genetics Restriction Mapping Streptomyces - enzymology Streptomyces - genetics Streptomyces - metabolism Transformation, Bacterial
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