Functional coupling between human E‐type Ca2+ channels and μ opioid receptors expressed in Xenopus oocytes

Neuronal α1E Ca2+ channels were expressed in Xenopus laevis oocytes alone and in combination with the μ opioid receptor. Macroscopic currents were recorded under voltage clamp conditions. The stimulation of the morphine receptor by the synthetic [d‐Ala2,N‐Me‐Phe4,Gly‐ol5] enkephalin (DAMGO) produced...

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Veröffentlicht in:	FEBS letters 1998-05, Vol.427 (1), p.96-102
Hauptverfasser:	Ottolia, Michela, Platano, Daniela, Qin, Ning, Noceti, Francesca, Birnbaumer, Mariel, Toro, Ligia, Birnbaumer, Lutz, Stefani, Enrico, Olcese, Riccardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - pharmacology Animals Beta subunit Ca2+ channel Calcium Channels - drug effects Calcium Channels - metabolism Enkephalin, Ala-MePhe-Gly Enkephalins - pharmacology G-protein GTP-Binding Proteins - drug effects GTP-Binding Proteins - metabolism Humans Membrane Potentials - drug effects Mu opioid receptor Narcotics - pharmacology Oocytes - drug effects Oocytes - metabolism Pertussis Toxin Receptors, Opioid, mu - drug effects Receptors, Opioid, mu - metabolism Virulence Factors, Bordetella - pharmacology Xenopus - genetics Xenopus - metabolism α1E
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