Cerebral white matter disease in late-onset paranoid psychosis
We examined magnetic resonance (MR) scans of the heads of 8 patients with late onset psychosis and 8 aged controls. Although some patients had mild cognitive impairment, none had depression or a history or examination suggesting focal brain disease. Thus, all patients met DSM-III-R criteria for late...
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| Veröffentlicht in: | Biological psychiatry (1969) 1990-08, Vol.28 (3), p.266-274 |
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| container_end_page | 274 |
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| container_title | Biological psychiatry (1969) |
| container_volume | 28 |
| creator | Breitner, John C.S. Husain, Mustafa M. Figiel, Gary S. Krishman, K.Ranga R. Boyko, Orest B. |
| description | We examined magnetic resonance (MR) scans of the heads of 8 patients with late onset psychosis and 8 aged controls. Although some patients had mild cognitive impairment, none had depression or a history or examination suggesting focal brain disease. Thus, all patients met DSM-III-R criteria for late-onset schizophrenia All 8 patients showed significant leukoencephalopathy or vascular pathology on MR imaging, and temporoparietal and occipital lesions were especially prominent. Little such pathology was evident on control scans. We suggest that focal brain disease of vascular origin may be associated with late-onset psychosis, and that MR scanning of such cases may provide important clues to pathologenesis. |
| doi_str_mv | 10.1016/0006-3223(90)90582-M |
| format | Article |
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Although some patients had mild cognitive impairment, none had depression or a history or examination suggesting focal brain disease. Thus, all patients met DSM-III-R criteria for late-onset schizophrenia All 8 patients showed significant leukoencephalopathy or vascular pathology on MR imaging, and temporoparietal and occipital lesions were especially prominent. Little such pathology was evident on control scans. We suggest that focal brain disease of vascular origin may be associated with late-onset psychosis, and that MR scanning of such cases may provide important clues to pathologenesis.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Delusions - diagnosis</subject><subject>Dementia - diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Hallucinations - diagnosis</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Neurocognitive Disorders - diagnosis</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Schizophrenia, Paranoid - diagnosis</topic><topic>Techniques and methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Breitner, John C.S.</creatorcontrib><creatorcontrib>Husain, Mustafa M.</creatorcontrib><creatorcontrib>Figiel, Gary S.</creatorcontrib><creatorcontrib>Krishman, K.Ranga R.</creatorcontrib><creatorcontrib>Boyko, Orest B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Breitner, John C.S.</au><au>Husain, Mustafa M.</au><au>Figiel, Gary S.</au><au>Krishman, K.Ranga R.</au><au>Boyko, Orest B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral white matter disease in late-onset paranoid psychosis</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1990-08-01</date><risdate>1990</risdate><volume>28</volume><issue>3</issue><spage>266</spage><epage>274</epage><pages>266-274</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>We examined magnetic resonance (MR) scans of the heads of 8 patients with late onset psychosis and 8 aged controls. 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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Aged Aged, 80 and over Biological and medical sciences Brain - pathology Delusions - diagnosis Dementia - diagnosis Diagnosis, Differential Female Hallucinations - diagnosis Humans Magnetic Resonance Imaging Male Medical sciences Middle Aged Miscellaneous Neurocognitive Disorders - diagnosis Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Schizophrenia, Paranoid - diagnosis Techniques and methods |
| title | Cerebral white matter disease in late-onset paranoid psychosis |
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