Susceptibilities of Mycobacterium malmoense determined at the growth optimum pH (pH 6.0)
Setting: Pulmonary disease caused by Mycobacterium malmoense is increasing. Conventional in vitro antimicrobial susceptibilities correlate poorly with response to treatment for this organism. Radiometrically determined minimum inhibitory concentrations (MICs) allow quantitative susceptibility testin...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 1998-05, Vol.2 (5), p.430-434 |
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| creator | Heginbothom Lindholm-Levy Heifets |
| description | Setting: Pulmonary disease caused by Mycobacterium malmoense is increasing. Conventional in vitro antimicrobial susceptibilities correlate poorly with response to treatment for this organism. Radiometrically determined minimum inhibitory concentrations (MICs) allow quantitative
susceptibility testing for non-tuberculous mycobacteria. The M. avium complex (MAC) has been investigated extensively with this approach, and clear interpretative criteria have been established at pH 6.8. However, there has been little work with the acidophilic M. malmoense,
which grows poorly at pH 6.8.Objective: To determine whether MICs at pH 6.0 provide results compatible with the interpretative criteria established for the MAC.Design: MICs were performed in Middlebrook PZA medium (pH 6.0) and 7H12 medium (pH 6.8) for ten strains of M. malmoense.Results:
MICs can be determined at pH 6.0 for M. malmoense using the criteria adopted for the M. avium complex.Conclusion: The low optimal pH of M. malmoense suits this organism for growth in acid conditions. As with MAC, M. malmoense multiplies within macrophages in
vivo, and MICs determined at pH 6.0 may reflect in vivo activity. The combination of radiometric MIC testing at optimal growth pH and interpretation based on pharmacokinetic parameters may be helpful in designing therapeutic regimens. |
| format | Article |
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susceptibility testing for non-tuberculous mycobacteria. The M. avium complex (MAC) has been investigated extensively with this approach, and clear interpretative criteria have been established at pH 6.8. However, there has been little work with the acidophilic M. malmoense,
which grows poorly at pH 6.8.Objective: To determine whether MICs at pH 6.0 provide results compatible with the interpretative criteria established for the MAC.Design: MICs were performed in Middlebrook PZA medium (pH 6.0) and 7H12 medium (pH 6.8) for ten strains of M. malmoense.Results:
MICs can be determined at pH 6.0 for M. malmoense using the criteria adopted for the M. avium complex.Conclusion: The low optimal pH of M. malmoense suits this organism for growth in acid conditions. As with MAC, M. malmoense multiplies within macrophages in
vivo, and MICs determined at pH 6.0 may reflect in vivo activity. The combination of radiometric MIC testing at optimal growth pH and interpretation based on pharmacokinetic parameters may be helpful in designing therapeutic regimens.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>PMID: 9613641</identifier><language>eng</language><publisher>Paris, France: IUATLD</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antimicrobial Susceptibility ; Bacteriological methods and techniques used in bacteriology ; Bacteriology ; Biological and medical sciences ; Culture Media ; Fundamental and applied biological sciences. Psychology ; Hydrogen-Ion Concentration ; Microbial Sensitivity Tests ; Microbiology ; Mycobacterium - classification ; Mycobacterium - drug effects ; Mycobacterium - growth & development ; Mycobacterium Malmoense</subject><ispartof>The international journal of tuberculosis and lung disease, 1998-05, Vol.2 (5), p.430-434</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2242848$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9613641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heginbothom</creatorcontrib><creatorcontrib>Lindholm-Levy</creatorcontrib><creatorcontrib>Heifets</creatorcontrib><title>Susceptibilities of Mycobacterium malmoense determined at the growth optimum pH (pH 6.0)</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>Setting: Pulmonary disease caused by Mycobacterium malmoense is increasing. Conventional in vitro antimicrobial susceptibilities correlate poorly with response to treatment for this organism. Radiometrically determined minimum inhibitory concentrations (MICs) allow quantitative
susceptibility testing for non-tuberculous mycobacteria. The M. avium complex (MAC) has been investigated extensively with this approach, and clear interpretative criteria have been established at pH 6.8. However, there has been little work with the acidophilic M. malmoense,
which grows poorly at pH 6.8.Objective: To determine whether MICs at pH 6.0 provide results compatible with the interpretative criteria established for the MAC.Design: MICs were performed in Middlebrook PZA medium (pH 6.0) and 7H12 medium (pH 6.8) for ten strains of M. malmoense.Results:
MICs can be determined at pH 6.0 for M. malmoense using the criteria adopted for the M. avium complex.Conclusion: The low optimal pH of M. malmoense suits this organism for growth in acid conditions. As with MAC, M. malmoense multiplies within macrophages in
vivo, and MICs determined at pH 6.0 may reflect in vivo activity. The combination of radiometric MIC testing at optimal growth pH and interpretation based on pharmacokinetic parameters may be helpful in designing therapeutic regimens.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antimicrobial Susceptibility</subject><subject>Bacteriological methods and techniques used in bacteriology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Culture Media</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Mycobacterium - classification</subject><subject>Mycobacterium - drug effects</subject><subject>Mycobacterium - growth & development</subject><subject>Mycobacterium Malmoense</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PwzAMhisEGmPwE5ByQAgORUnaJs0RjY8hDXFgB25Rmrhbpn6MJBXavyfTCpbs17If2bJPkikpSZFyQfFpzDHlacaJOE8uvN9iTAkhfJJMBCMZy8k0-focvIZdsJVtbLDgUV-j973uK6UDODu0qFVN20PnARmIpdZ2YJAKKGwArV3_EzaojwPaiO4W6C46e8D3l8lZrRoPV6POktXL82q-SJcfr2_zx2VqqWAhrShhObDaqApnuoSMasAYtBZKl4xTQ8q6NJEqmOZVUXDMWU5VxIzWdZnNktvj2J3rvwfwQbY2HtQ0qoN-8JILQTAWPILXIzhULRi5c7ZVbi_HT8T-zdhXXqumdqrT1v9jlOa0zA_7no6Y7dbQBSW3_eC6eKC0gwqNkXZ7iESIUuKj0b-kkMqFqCTLfgFEnn2y</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Heginbothom</creator><creator>Lindholm-Levy</creator><creator>Heifets</creator><general>IUATLD</general><general>Union internationale contre la tuberculose et les maladies respiratoires</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19980501</creationdate><title>Susceptibilities of Mycobacterium malmoense determined at the growth optimum pH (pH 6.0)</title><author>Heginbothom ; Lindholm-Levy ; Heifets</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i296t-b2164e6fdab03c8e32ce00ecc9ac8672d18f8db2156c7b55707642a32cdccf83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antimicrobial Susceptibility</topic><topic>Bacteriological methods and techniques used in bacteriology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Culture Media</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Mycobacterium - classification</topic><topic>Mycobacterium - drug effects</topic><topic>Mycobacterium - growth & development</topic><topic>Mycobacterium Malmoense</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heginbothom</creatorcontrib><creatorcontrib>Lindholm-Levy</creatorcontrib><creatorcontrib>Heifets</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heginbothom</au><au>Lindholm-Levy</au><au>Heifets</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Susceptibilities of Mycobacterium malmoense determined at the growth optimum pH (pH 6.0)</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>2</volume><issue>5</issue><spage>430</spage><epage>434</epage><pages>430-434</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>Setting: Pulmonary disease caused by Mycobacterium malmoense is increasing. Conventional in vitro antimicrobial susceptibilities correlate poorly with response to treatment for this organism. Radiometrically determined minimum inhibitory concentrations (MICs) allow quantitative
susceptibility testing for non-tuberculous mycobacteria. The M. avium complex (MAC) has been investigated extensively with this approach, and clear interpretative criteria have been established at pH 6.8. However, there has been little work with the acidophilic M. malmoense,
which grows poorly at pH 6.8.Objective: To determine whether MICs at pH 6.0 provide results compatible with the interpretative criteria established for the MAC.Design: MICs were performed in Middlebrook PZA medium (pH 6.0) and 7H12 medium (pH 6.8) for ten strains of M. malmoense.Results:
MICs can be determined at pH 6.0 for M. malmoense using the criteria adopted for the M. avium complex.Conclusion: The low optimal pH of M. malmoense suits this organism for growth in acid conditions. As with MAC, M. malmoense multiplies within macrophages in
vivo, and MICs determined at pH 6.0 may reflect in vivo activity. The combination of radiometric MIC testing at optimal growth pH and interpretation based on pharmacokinetic parameters may be helpful in designing therapeutic regimens.</abstract><cop>Paris, France</cop><pub>IUATLD</pub><pmid>9613641</pmid><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Anti-Bacterial Agents - pharmacology Antimicrobial Susceptibility Bacteriological methods and techniques used in bacteriology Bacteriology Biological and medical sciences Culture Media Fundamental and applied biological sciences. Psychology Hydrogen-Ion Concentration Microbial Sensitivity Tests Microbiology Mycobacterium - classification Mycobacterium - drug effects Mycobacterium - growth & development Mycobacterium Malmoense |
| title | Susceptibilities of Mycobacterium malmoense determined at the growth optimum pH (pH 6.0) |
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