Effect of carnitine and essential fatty acid supplementation on the uptake of 11C-carnitine in muscle of a myopathic carnitine-deficient patient using positron emission scintigraphy
The aim of this study was to demonstrate the pattern of 11C-carnitine uptake after various treatment regimens in a myopathic carnitine-deficient patient and two normal volunteers, using a whole body counter specially adapted for positron emission. One carnitine-deficient patient and two normal volun...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 1998-03, Vol.58 (3), p.201-204 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | Dippenaar, N. Clauss, R.P. Feinendegen, L.E. |
| description | The aim of this study was to demonstrate the pattern of
11C-carnitine uptake after various treatment regimens in a myopathic carnitine-deficient patient and two normal volunteers, using a whole body counter specially adapted for positron emission. One carnitine-deficient patient and two normal volunteers were scanned after an intravenous injection of
11C-carnitine, both while on carnitine therapy and after discontinuation thereof. The third scan was done on the patient following carnitine and fatty acid therapy for 7 days. Both the carnitine-deficient patient and the normal volunteers showed improved
11C-carnitine uptake by thigh muscles after carnitine supplementation, and the carnitine-deficient patient even more so after carnitine and fatty acid supplementation. It is therefore concluded that the scintigraphic findings support the clinical impression that carnitine deficient patients improve after carnitine and essential fatty acid supplementation. |
| doi_str_mv | 10.1016/S0952-3278(98)90114-4 |
| format | Article |
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11C-carnitine uptake after various treatment regimens in a myopathic carnitine-deficient patient and two normal volunteers, using a whole body counter specially adapted for positron emission. One carnitine-deficient patient and two normal volunteers were scanned after an intravenous injection of
11C-carnitine, both while on carnitine therapy and after discontinuation thereof. The third scan was done on the patient following carnitine and fatty acid therapy for 7 days. Both the carnitine-deficient patient and the normal volunteers showed improved
11C-carnitine uptake by thigh muscles after carnitine supplementation, and the carnitine-deficient patient even more so after carnitine and fatty acid supplementation. It is therefore concluded that the scintigraphic findings support the clinical impression that carnitine deficient patients improve after carnitine and essential fatty acid supplementation.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1016/S0952-3278(98)90114-4</identifier><identifier>PMID: 9610842</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Carbon Radioisotopes ; Carnitine - deficiency ; Carnitine - pharmacokinetics ; Carnitine - therapeutic use ; Child ; Child, Preschool ; Dietary Supplements ; Fatty Acids, Essential - administration & dosage ; Fatty Acids, Essential - therapeutic use ; Female ; Humans ; Infant ; Medical sciences ; Muscle ; Muscular Atrophy - diagnostic imaging ; Muscular Atrophy - drug therapy ; Muscular Atrophy - metabolism ; Pharmacology. Drug treatments ; Tomography, Emission-Computed</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 1998-03, Vol.58 (3), p.201-204</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2362-81ce5ba1a21d904731ea76cd6629e91cfc381bc47cdd626703643fba5849d5da3</citedby><cites>FETCH-LOGICAL-c2362-81ce5ba1a21d904731ea76cd6629e91cfc381bc47cdd626703643fba5849d5da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0952327898901144$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2220180$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9610842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dippenaar, N.</creatorcontrib><creatorcontrib>Clauss, R.P.</creatorcontrib><creatorcontrib>Feinendegen, L.E.</creatorcontrib><title>Effect of carnitine and essential fatty acid supplementation on the uptake of 11C-carnitine in muscle of a myopathic carnitine-deficient patient using positron emission scintigraphy</title><title>Prostaglandins, leukotrienes and essential fatty acids</title><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><description>The aim of this study was to demonstrate the pattern of
11C-carnitine uptake after various treatment regimens in a myopathic carnitine-deficient patient and two normal volunteers, using a whole body counter specially adapted for positron emission. One carnitine-deficient patient and two normal volunteers were scanned after an intravenous injection of
11C-carnitine, both while on carnitine therapy and after discontinuation thereof. The third scan was done on the patient following carnitine and fatty acid therapy for 7 days. Both the carnitine-deficient patient and the normal volunteers showed improved
11C-carnitine uptake by thigh muscles after carnitine supplementation, and the carnitine-deficient patient even more so after carnitine and fatty acid supplementation. It is therefore concluded that the scintigraphic findings support the clinical impression that carnitine deficient patients improve after carnitine and essential fatty acid supplementation.</description><subject>Biological and medical sciences</subject><subject>Carbon Radioisotopes</subject><subject>Carnitine - deficiency</subject><subject>Carnitine - pharmacokinetics</subject><subject>Carnitine - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dietary Supplements</subject><subject>Fatty Acids, Essential - administration & dosage</subject><subject>Fatty Acids, Essential - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Medical sciences</subject><subject>Muscle</subject><subject>Muscular Atrophy - diagnostic imaging</subject><subject>Muscular Atrophy - drug therapy</subject><subject>Muscular Atrophy - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Tomography, Emission-Computed</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuKVDEQhoMoYzv6CANZiOjiaJJzzUqkGS8w4EJdh-pKZTp6biY5Qj-Y72dOd9OzFApq8X_1V1E_YzdSvJVCNu--CV2rolRt91p3b7SQsiqqR2wj61IVqlPlY7a5IE_Zsxh_CiFUxq7YlW6k6Cq1YX9vnSNMfHIcIYw--ZE4jJZTjDQmDz13kNKBA3rL4zLPPQ1ZgOSnkedKe-LLnOAXrR5SbosHHz_yYYnYHyXgw2GaIe09PqwqLDmPPhvyLB37Ev14z-cp-hSyPw0-xnVXRJ_vuQ8w7w_P2RMHfaQX537Nfny8_b79XNx9_fRl--GuQFU2qugkUr0DCUpaLaq2lARtg7ZplCYt0WHZyR1WLVrbqKYVZVOVbgd1V2lbWyiv2auT7xym3wvFZPI1SH0PI01LNK3WQitdZbA-gRimGAM5Mwc_QDgYKcwalznGZdYsjM61xmXWuZvzgmU3kL1MnfPJ-suzDhGhdwFG9PGCKaWE7ETG3p8wys_44ymYuD4VyfqQ0zV28v855B9dWLXi</recordid><startdate>199803</startdate><enddate>199803</enddate><creator>Dippenaar, N.</creator><creator>Clauss, R.P.</creator><creator>Feinendegen, L.E.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199803</creationdate><title>Effect of carnitine and essential fatty acid supplementation on the uptake of 11C-carnitine in muscle of a myopathic carnitine-deficient patient using positron emission scintigraphy</title><author>Dippenaar, N. ; Clauss, R.P. ; Feinendegen, L.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2362-81ce5ba1a21d904731ea76cd6629e91cfc381bc47cdd626703643fba5849d5da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>Carbon Radioisotopes</topic><topic>Carnitine - deficiency</topic><topic>Carnitine - pharmacokinetics</topic><topic>Carnitine - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dietary Supplements</topic><topic>Fatty Acids, Essential - administration & dosage</topic><topic>Fatty Acids, Essential - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Medical sciences</topic><topic>Muscle</topic><topic>Muscular Atrophy - diagnostic imaging</topic><topic>Muscular Atrophy - drug therapy</topic><topic>Muscular Atrophy - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dippenaar, N.</creatorcontrib><creatorcontrib>Clauss, R.P.</creatorcontrib><creatorcontrib>Feinendegen, L.E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dippenaar, N.</au><au>Clauss, R.P.</au><au>Feinendegen, L.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of carnitine and essential fatty acid supplementation on the uptake of 11C-carnitine in muscle of a myopathic carnitine-deficient patient using positron emission scintigraphy</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>1998-03</date><risdate>1998</risdate><volume>58</volume><issue>3</issue><spage>201</spage><epage>204</epage><pages>201-204</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>The aim of this study was to demonstrate the pattern of
11C-carnitine uptake after various treatment regimens in a myopathic carnitine-deficient patient and two normal volunteers, using a whole body counter specially adapted for positron emission. One carnitine-deficient patient and two normal volunteers were scanned after an intravenous injection of
11C-carnitine, both while on carnitine therapy and after discontinuation thereof. The third scan was done on the patient following carnitine and fatty acid therapy for 7 days. Both the carnitine-deficient patient and the normal volunteers showed improved
11C-carnitine uptake by thigh muscles after carnitine supplementation, and the carnitine-deficient patient even more so after carnitine and fatty acid supplementation. It is therefore concluded that the scintigraphic findings support the clinical impression that carnitine deficient patients improve after carnitine and essential fatty acid supplementation.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>9610842</pmid><doi>10.1016/S0952-3278(98)90114-4</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0952-3278 |
| ispartof | Prostaglandins, leukotrienes and essential fatty acids, 1998-03, Vol.58 (3), p.201-204 |
| issn | 0952-3278 1532-2823 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79909294 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Carbon Radioisotopes Carnitine - deficiency Carnitine - pharmacokinetics Carnitine - therapeutic use Child Child, Preschool Dietary Supplements Fatty Acids, Essential - administration & dosage Fatty Acids, Essential - therapeutic use Female Humans Infant Medical sciences Muscle Muscular Atrophy - diagnostic imaging Muscular Atrophy - drug therapy Muscular Atrophy - metabolism Pharmacology. Drug treatments Tomography, Emission-Computed |
| title | Effect of carnitine and essential fatty acid supplementation on the uptake of 11C-carnitine in muscle of a myopathic carnitine-deficient patient using positron emission scintigraphy |
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