Study of behavioral phenotypes: Goals and methodological considerations
The study of behavioral phenotypes associated with genetic syndromes has gained increasing momentum over the past two decades. In this paper, the definition of behavioral phenotypes is presented and the complexities and obstacles to progress in this field are summarized. Also described are the goals...
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| Veröffentlicht in: | American journal of medical genetics 1998-03, Vol.81 (2), p.148-155 |
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| creator | Finegan, Jo-Anne |
| description | The study of behavioral phenotypes associated with genetic syndromes has gained increasing momentum over the past two decades. In this paper, the definition of behavioral phenotypes is presented and the complexities and obstacles to progress in this field are summarized. Also described are the goals of such investigations, including the need for syndrome delineation, provision of guidance for clinical management, contributions to understanding brain‐behavior relations, advancements in developmental theory, and gaining understanding of the genetic bases of behavior. Methodological issues addressed in relation to such goals include the need for cross‐disciplinary collaboration, concerns regarding sampling methods and comparison group selection, and developmental considerations. The complexity of cognitive abilities, the limitations of existing tests and measures, and ways of approaching the study of behavior are discussed. A final comment concerns the potential risks of research in behavioral phenotypes. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81: 148–155, 1998. © 1998 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1096-8628(19980328)81:2<148::AID-AJMG5>3.0.CO;2-S |
| format | Article |
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J. Med. Genet</addtitle><description>The study of behavioral phenotypes associated with genetic syndromes has gained increasing momentum over the past two decades. In this paper, the definition of behavioral phenotypes is presented and the complexities and obstacles to progress in this field are summarized. Also described are the goals of such investigations, including the need for syndrome delineation, provision of guidance for clinical management, contributions to understanding brain‐behavior relations, advancements in developmental theory, and gaining understanding of the genetic bases of behavior. Methodological issues addressed in relation to such goals include the need for cross‐disciplinary collaboration, concerns regarding sampling methods and comparison group selection, and developmental considerations. The complexity of cognitive abilities, the limitations of existing tests and measures, and ways of approaching the study of behavior are discussed. A final comment concerns the potential risks of research in behavioral phenotypes. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81: 148–155, 1998. © 1998 Wiley‐Liss, Inc.</description><subject>behavior</subject><subject>behavioral phenotypes</subject><subject>Behavioral Symptoms - genetics</subject><subject>Behavioral Symptoms - psychology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child Behavior Disorders - genetics</subject><subject>Child Behavior Disorders - psychology</subject><subject>cognition</subject><subject>development</subject><subject>Genetic Diseases, Inborn - genetics</subject><subject>Genetic Diseases, Inborn - psychology</subject><subject>Genetics, Behavioral</subject><subject>Humans</subject><subject>Intellectual Disability - genetics</subject><subject>Intellectual Disability - psychology</subject><subject>Medical sciences</subject><subject>Mental Disorders - genetics</subject><subject>Mental Disorders - psychology</subject><subject>mental retardation</subject><subject>Miscellaneous</subject><subject>Phenotype</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>psychopathology</subject><subject>Psychopathology. Psychiatry</subject><subject>Research Design</subject><subject>Syndrome</subject><subject>syndromes</subject><subject>Techniques and methods</subject><issn>0148-7299</issn><issn>1096-8628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1v0zAUhi0EGt3gJyDlAqHtIsUfieNTEFMXWCja6EWKxt2Rk7g0I41LnAL997ik9AYkrmyd8_jVq8eEXDI6ZpTyl-f5LJ1dMAoyVJKrcwagqODqQrEJf80iNZlMZ2_D6YfbLH4jxnSczl_xMH9ARsc3D8mIejBMOMBjcurcPaXMD_gJOQHJhIqjEcnyflvtArsMCrPS32vb6SbYrExr-93GuEmQWd24QLdVsDb9yla2sV_q0kOlbV1dmU73tb89IY-WHjRPD-cZ-XT9bpG-D2_m2Syd3oRlJKI4FEnMK2YKQ-UyiSBilRaJ9EdiisiwQiYKQGgoAQpZqFIXwLhkUlSxhLIw4oy8GHI3nf22Na7Hde1K0zS6NXbrMAGgwCDx4N0Alp11rjNL3HT1Wnc7ZBT3ihH3inGvC_e68I9iVAw5elGIXjH-VowCKaZzP8998rNDhW2xNtUx9-DU758f9tp5UctOt2XtjhjnXAFnHvs8YD_qxuz-avffcv_qNgx8dDhE1643P4_RuvuKMvFfgHcfM7xa5FfZdbzAW_ELY0Czig</recordid><startdate>19980328</startdate><enddate>19980328</enddate><creator>Finegan, Jo-Anne</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980328</creationdate><title>Study of behavioral phenotypes: Goals and methodological considerations</title><author>Finegan, Jo-Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4345-3752d1ebe06f74941da37641d7eb4e1b678993a9c99b6b8cab9126163d569cbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>behavior</topic><topic>behavioral phenotypes</topic><topic>Behavioral Symptoms - genetics</topic><topic>Behavioral Symptoms - psychology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child Behavior Disorders - genetics</topic><topic>Child Behavior Disorders - psychology</topic><topic>cognition</topic><topic>development</topic><topic>Genetic Diseases, Inborn - genetics</topic><topic>Genetic Diseases, Inborn - psychology</topic><topic>Genetics, Behavioral</topic><topic>Humans</topic><topic>Intellectual Disability - genetics</topic><topic>Intellectual Disability - psychology</topic><topic>Medical sciences</topic><topic>Mental Disorders - genetics</topic><topic>Mental Disorders - psychology</topic><topic>mental retardation</topic><topic>Miscellaneous</topic><topic>Phenotype</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>psychopathology</topic><topic>Psychopathology. Psychiatry</topic><topic>Research Design</topic><topic>Syndrome</topic><topic>syndromes</topic><topic>Techniques and methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Finegan, Jo-Anne</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of medical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Finegan, Jo-Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of behavioral phenotypes: Goals and methodological considerations</atitle><jtitle>American journal of medical genetics</jtitle><addtitle>Am. J. Med. Genet</addtitle><date>1998-03-28</date><risdate>1998</risdate><volume>81</volume><issue>2</issue><spage>148</spage><epage>155</epage><pages>148-155</pages><issn>0148-7299</issn><eissn>1096-8628</eissn><coden>AJMGDA</coden><abstract>The study of behavioral phenotypes associated with genetic syndromes has gained increasing momentum over the past two decades. In this paper, the definition of behavioral phenotypes is presented and the complexities and obstacles to progress in this field are summarized. Also described are the goals of such investigations, including the need for syndrome delineation, provision of guidance for clinical management, contributions to understanding brain‐behavior relations, advancements in developmental theory, and gaining understanding of the genetic bases of behavior. Methodological issues addressed in relation to such goals include the need for cross‐disciplinary collaboration, concerns regarding sampling methods and comparison group selection, and developmental considerations. The complexity of cognitive abilities, the limitations of existing tests and measures, and ways of approaching the study of behavior are discussed. A final comment concerns the potential risks of research in behavioral phenotypes. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81: 148–155, 1998. © 1998 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>9613854</pmid><doi>10.1002/(SICI)1096-8628(19980328)81:2<148::AID-AJMG5>3.0.CO;2-S</doi><tpages>8</tpages></addata></record> |
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| subjects | behavior behavioral phenotypes Behavioral Symptoms - genetics Behavioral Symptoms - psychology Biological and medical sciences Child Child Behavior Disorders - genetics Child Behavior Disorders - psychology cognition development Genetic Diseases, Inborn - genetics Genetic Diseases, Inborn - psychology Genetics, Behavioral Humans Intellectual Disability - genetics Intellectual Disability - psychology Medical sciences Mental Disorders - genetics Mental Disorders - psychology mental retardation Miscellaneous Phenotype Psychology. Psychoanalysis. Psychiatry psychopathology Psychopathology. Psychiatry Research Design Syndrome syndromes Techniques and methods |
| title | Study of behavioral phenotypes: Goals and methodological considerations |
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