Evidence that the ubiquitin proteolytic pathway is involved in the degradation of precipitated globin chains in thalassaemia

Ultrastructural immunocytochemical studies were performed on sections of bone marrow from three patients with β‐thalassaemia major and two patients with haemoglobin H (HbH) disease. Some sections were reacted with either a polyclonal or a monoclonal anti‐human‐ubiquitin antibody and the reaction vis...

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