The Role of Dietary Zinc in Modifying the Onset and Severity of Spontaneous Diabetes in the BB Wistar Rat

The goal of this study was to determine whether zinc supplementation in the diet of diabetes-prone BB Wistar rats will delay or prevent the onset of overt diabetes. Male Wistar BB rats were fed diets containing either 1000 ppm (HZ), 50 ppm (NZ), or 1 ppm zinc (LZ) starting at 30 days of age. Non-dia...

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Veröffentlicht in:	Molecular genetics and metabolism 1998-03, Vol.63 (3), p.205-213
Hauptverfasser:	Tobia, Mario H., Zdanowicz, Martin M., Wingertzahn, Mark A., McHeffey-Atkinson, Barbara, Slonim, Alfred E., Wapnir, Raul A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Animals BB Wistar rat Blood Glucose - analysis Cholesterol - blood Copper - analysis Copper - blood diabetes Diabetes Mellitus, Type 1 - prevention & control Diet Dose-Response Relationship, Drug Glucose Tolerance Test Humans Immunohistochemistry Insulin - analysis Insulin - blood insulin secretion insulitis Islets of Langerhans - pathology Male Pancreas - metabolism Pancreas - pathology Rats Rats, Inbred BB Triglycerides - blood Weight Gain zinc Zinc - administration & dosage Zinc - analysis Zinc - therapeutic use
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