Epstein-Barr virus involvement in gastric cancer: biomarker for lymph node metastasis
EBV involvement in gastric cancer is characterized by episomal monoclonality, high antibody titers, EBV encoded small RNA and EBV nuclear antigen 1 expression in all tumor cells, and in the intramucosal stage, by a unique morphology. EBV involvement varies by population (approximately 7% of gastric...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 1998-05, Vol.7 (5), p.449-450 |
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| creator | Tokunaga, M Land, C E |
| description | EBV involvement in gastric cancer is characterized by episomal monoclonality, high antibody titers, EBV encoded small RNA
and EBV nuclear antigen 1 expression in all tumor cells, and in the intramucosal stage, by a unique morphology. EBV involvement
varies by population (approximately 7% of gastric cancers in Japan and >15% in Western countries), sex, histological type,
and tumor location. The present study compares frequency of lymph node metastasis (LNM) between 170 EBV-positive and 1590
EBV-negative gastric cancer cases in Japan by level of invasiveness. Frequency of LNM increased with increasing depth of invasiveness
but was consistently and significantly greater for EBV-negative cases (P = 0.0018). In particular, there were no instances
of LNM among 75 EBV-positive cases as compared with 53 among 562 EBV-negative cases restricted to the mucosa and submucosa
(odds ratio, 0; 95% confidence limits, 0-0.20). The finding suggests that genetic control of metastasis may differ between
EBV-related and other gastric cancers. Also, the possibility that EBV-positive, noninvasive gastric cancers may not require
lymph node dissection suggests that routine assay of biopsy specimens for EBV involvement could be important in populations,
like that of Japan, where early gastric cancers are seen frequently. |
| format | Article |
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and EBV nuclear antigen 1 expression in all tumor cells, and in the intramucosal stage, by a unique morphology. EBV involvement
varies by population (approximately 7% of gastric cancers in Japan and >15% in Western countries), sex, histological type,
and tumor location. The present study compares frequency of lymph node metastasis (LNM) between 170 EBV-positive and 1590
EBV-negative gastric cancer cases in Japan by level of invasiveness. Frequency of LNM increased with increasing depth of invasiveness
but was consistently and significantly greater for EBV-negative cases (P = 0.0018). In particular, there were no instances
of LNM among 75 EBV-positive cases as compared with 53 among 562 EBV-negative cases restricted to the mucosa and submucosa
(odds ratio, 0; 95% confidence limits, 0-0.20). The finding suggests that genetic control of metastasis may differ between
EBV-related and other gastric cancers. Also, the possibility that EBV-positive, noninvasive gastric cancers may not require
lymph node dissection suggests that routine assay of biopsy specimens for EBV involvement could be important in populations,
like that of Japan, where early gastric cancers are seen frequently.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>PMID: 9610796</identifier><language>eng</language><publisher>United States: American Association for Cancer Research</publisher><subject>Herpesviridae Infections - pathology ; Herpesviridae Infections - virology ; Herpesvirus 4, Human - isolation & purification ; Humans ; Lymph Nodes - pathology ; Lymph Nodes - virology ; Lymphatic Metastasis ; Stomach Neoplasms - pathology ; Stomach Neoplasms - virology ; Tumor Virus Infections - pathology ; Tumor Virus Infections - virology</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 1998-05, Vol.7 (5), p.449-450</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9610796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tokunaga, M</creatorcontrib><creatorcontrib>Land, C E</creatorcontrib><title>Epstein-Barr virus involvement in gastric cancer: biomarker for lymph node metastasis</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>EBV involvement in gastric cancer is characterized by episomal monoclonality, high antibody titers, EBV encoded small RNA
and EBV nuclear antigen 1 expression in all tumor cells, and in the intramucosal stage, by a unique morphology. EBV involvement
varies by population (approximately 7% of gastric cancers in Japan and >15% in Western countries), sex, histological type,
and tumor location. The present study compares frequency of lymph node metastasis (LNM) between 170 EBV-positive and 1590
EBV-negative gastric cancer cases in Japan by level of invasiveness. Frequency of LNM increased with increasing depth of invasiveness
but was consistently and significantly greater for EBV-negative cases (P = 0.0018). In particular, there were no instances
of LNM among 75 EBV-positive cases as compared with 53 among 562 EBV-negative cases restricted to the mucosa and submucosa
(odds ratio, 0; 95% confidence limits, 0-0.20). The finding suggests that genetic control of metastasis may differ between
EBV-related and other gastric cancers. Also, the possibility that EBV-positive, noninvasive gastric cancers may not require
lymph node dissection suggests that routine assay of biopsy specimens for EBV involvement could be important in populations,
like that of Japan, where early gastric cancers are seen frequently.</description><subject>Herpesviridae Infections - pathology</subject><subject>Herpesviridae Infections - virology</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Humans</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - virology</subject><subject>Lymphatic Metastasis</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - virology</subject><subject>Tumor Virus Infections - pathology</subject><subject>Tumor Virus Infections - virology</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLxDAURoMo4zj6E4Ss3BXSpjeZuNNhfMCAG2cd0uR2Gu3LpK3Mv7cwA67uWRw-OPeCLFPg60RKgMuZGUCilIBrchPjF2NMKoAFWSiRziiWZL_t44C-TZ5NCHTyYYzUt1NXT9hgO8xMDyYOwVtqTWsxPNLCd40J3xho2QVaH5u-om3nkDY4zKqJPt6Sq9LUEe_Od0X2L9vPzVuy-3h93zztkirjckiKVBpQPM95KXgmS1cyKJlc87khTSGzyhnHuVScCwPGCgdGpoXJBDjMBeMr8nDa7UP3M2IcdOOjxbo2LXZj1FIplmdrNYv3Z3EsGnS6D35uOOrzH_6HKn-ofn1AfaoNGNEEW2mpQee54n8w0mgu</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Tokunaga, M</creator><creator>Land, C E</creator><general>American Association for Cancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19980501</creationdate><title>Epstein-Barr virus involvement in gastric cancer: biomarker for lymph node metastasis</title><author>Tokunaga, M ; Land, C E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h237t-b17a593443f6327fdf05f07831531152c9dad3379336a5ac6d5a71ba265de4603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Herpesviridae Infections - pathology</topic><topic>Herpesviridae Infections - virology</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Humans</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - virology</topic><topic>Lymphatic Metastasis</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - virology</topic><topic>Tumor Virus Infections - pathology</topic><topic>Tumor Virus Infections - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tokunaga, M</creatorcontrib><creatorcontrib>Land, C E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tokunaga, M</au><au>Land, C E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epstein-Barr virus involvement in gastric cancer: biomarker for lymph node metastasis</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>7</volume><issue>5</issue><spage>449</spage><epage>450</epage><pages>449-450</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>EBV involvement in gastric cancer is characterized by episomal monoclonality, high antibody titers, EBV encoded small RNA
and EBV nuclear antigen 1 expression in all tumor cells, and in the intramucosal stage, by a unique morphology. EBV involvement
varies by population (approximately 7% of gastric cancers in Japan and >15% in Western countries), sex, histological type,
and tumor location. The present study compares frequency of lymph node metastasis (LNM) between 170 EBV-positive and 1590
EBV-negative gastric cancer cases in Japan by level of invasiveness. Frequency of LNM increased with increasing depth of invasiveness
but was consistently and significantly greater for EBV-negative cases (P = 0.0018). In particular, there were no instances
of LNM among 75 EBV-positive cases as compared with 53 among 562 EBV-negative cases restricted to the mucosa and submucosa
(odds ratio, 0; 95% confidence limits, 0-0.20). The finding suggests that genetic control of metastasis may differ between
EBV-related and other gastric cancers. Also, the possibility that EBV-positive, noninvasive gastric cancers may not require
lymph node dissection suggests that routine assay of biopsy specimens for EBV involvement could be important in populations,
like that of Japan, where early gastric cancers are seen frequently.</abstract><cop>United States</cop><pub>American Association for Cancer Research</pub><pmid>9610796</pmid><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1055-9965 |
| ispartof | Cancer epidemiology, biomarkers & prevention, 1998-05, Vol.7 (5), p.449-450 |
| issn | 1055-9965 1538-7755 |
| language | eng |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Herpesviridae Infections - pathology Herpesviridae Infections - virology Herpesvirus 4, Human - isolation & purification Humans Lymph Nodes - pathology Lymph Nodes - virology Lymphatic Metastasis Stomach Neoplasms - pathology Stomach Neoplasms - virology Tumor Virus Infections - pathology Tumor Virus Infections - virology |
| title | Epstein-Barr virus involvement in gastric cancer: biomarker for lymph node metastasis |
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