Recurrent urticaria and reduced diamine oxidase activity
Summary An abnormal metabolism of histamine has been suspected in urticaria and the role of diamine oxidase (DAO; histaminase) is therefore of interest. We have studied DAO activity in plasma and jejunal biopsy material and have measured the post‐heparin DAO release in 11 control subjects and nine w...
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| Veröffentlicht in: | Clinical and experimental allergy 1990-07, Vol.20 (4), p.373-376 |
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| container_title | Clinical and experimental allergy |
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| creator | LESSOF, M. H. GANT, V. HINUMA, K. MURPHY, G. M. DOWLING, R. H. |
| description | Summary
An abnormal metabolism of histamine has been suspected in urticaria and the role of diamine oxidase (DAO; histaminase) is therefore of interest. We have studied DAO activity in plasma and jejunal biopsy material and have measured the post‐heparin DAO release in 11 control subjects and nine with recurrent urticaria, three of whom had had concurrent episodes of abdominal pain. Two of the nine urticaria subjects had only a minimal rise in plasma DAO activity after heparin, three had a response which was at the lower end of the normal range, and four were normal. In four out of five cases in which jejunal biopsy activity was obtained, there was concordance between mucosal DAO activity and the post‐heparin plasma DAO response. Those with abdominal symptoms had abnormally low mucosal DAO activity and the subject who was most severely affected had proven episodes of small bowel oedema. |
| doi_str_mv | 10.1111/j.1365-2222.1990.tb02796.x |
| format | Article |
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An abnormal metabolism of histamine has been suspected in urticaria and the role of diamine oxidase (DAO; histaminase) is therefore of interest. We have studied DAO activity in plasma and jejunal biopsy material and have measured the post‐heparin DAO release in 11 control subjects and nine with recurrent urticaria, three of whom had had concurrent episodes of abdominal pain. Two of the nine urticaria subjects had only a minimal rise in plasma DAO activity after heparin, three had a response which was at the lower end of the normal range, and four were normal. In four out of five cases in which jejunal biopsy activity was obtained, there was concordance between mucosal DAO activity and the post‐heparin plasma DAO response. Those with abdominal symptoms had abnormally low mucosal DAO activity and the subject who was most severely affected had proven episodes of small bowel oedema.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.1990.tb02796.x</identifier><identifier>PMID: 2115815</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Amine Oxidase (Copper-Containing) - blood ; Amine Oxidase (Copper-Containing) - metabolism ; Biological and medical sciences ; Colic - complications ; Female ; Heparin - administration & dosage ; Humans ; Immunopathology ; Intestinal Mucosa - enzymology ; Jejunum - enzymology ; Male ; Medical sciences ; Middle Aged ; Recurrence ; Urticaria - complications ; Urticaria - enzymology</subject><ispartof>Clinical and experimental allergy, 1990-07, Vol.20 (4), p.373-376</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5023-fdb71430c6cddfc0fb4148331c116bc7c46417f75c8ef4929c196799c4f2a4c03</citedby><cites>FETCH-LOGICAL-c5023-fdb71430c6cddfc0fb4148331c116bc7c46417f75c8ef4929c196799c4f2a4c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2222.1990.tb02796.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2222.1990.tb02796.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4576956$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2115815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LESSOF, M. H.</creatorcontrib><creatorcontrib>GANT, V.</creatorcontrib><creatorcontrib>HINUMA, K.</creatorcontrib><creatorcontrib>MURPHY, G. M.</creatorcontrib><creatorcontrib>DOWLING, R. H.</creatorcontrib><title>Recurrent urticaria and reduced diamine oxidase activity</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Summary
An abnormal metabolism of histamine has been suspected in urticaria and the role of diamine oxidase (DAO; histaminase) is therefore of interest. We have studied DAO activity in plasma and jejunal biopsy material and have measured the post‐heparin DAO release in 11 control subjects and nine with recurrent urticaria, three of whom had had concurrent episodes of abdominal pain. Two of the nine urticaria subjects had only a minimal rise in plasma DAO activity after heparin, three had a response which was at the lower end of the normal range, and four were normal. In four out of five cases in which jejunal biopsy activity was obtained, there was concordance between mucosal DAO activity and the post‐heparin plasma DAO response. Those with abdominal symptoms had abnormally low mucosal DAO activity and the subject who was most severely affected had proven episodes of small bowel oedema.</description><subject>Adult</subject><subject>Aged</subject><subject>Amine Oxidase (Copper-Containing) - blood</subject><subject>Amine Oxidase (Copper-Containing) - metabolism</subject><subject>Biological and medical sciences</subject><subject>Colic - complications</subject><subject>Female</subject><subject>Heparin - administration & dosage</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Intestinal Mucosa - enzymology</subject><subject>Jejunum - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Recurrence</subject><subject>Urticaria - complications</subject><subject>Urticaria - enzymology</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1r2zAUhkVZ6dKsP2FgxuidXcn6snpR6ELWDZqOlpbBboR8JIEyx8kku03-_Rxict9zo4v3Oa8OD0JfCC7IMFfLglDB83KYgiiFi67GpVSi2J6gyTH6gCZYcZbLSrGP6DylJcaYclWdobOSEF4RPkHVk4M-Rtd2WR-7ACYGk5nWZtHZHpzNbDCr0LpsvQ3WJJcZ6MJr6Haf0Kk3TXIX4ztFL9_nz7Mf-f2vu5-z2_scOC5p7m0tCaMYBFjrAfuaEVZRSoAQUYMEJhiRXnKonGeqVECUkEoB86VhgOkUXR56N3H9r3ep06uQwDWNad26T3pgMWacD-D1AYS4Tik6rzcxrEzcaYL1Xpte6r0bvXej99r0qE1vh-XP4y99vXL2uDp6GvKvY24SmMZH00JIR4xxKRQXA3ZzwN5C43bvOEDP5rdU0qEgPxSE1LntscDEv1pIKrn-_XCnH8W3P4tqsdCY_gdKzJg5</recordid><startdate>199007</startdate><enddate>199007</enddate><creator>LESSOF, M. H.</creator><creator>GANT, V.</creator><creator>HINUMA, K.</creator><creator>MURPHY, G. M.</creator><creator>DOWLING, R. H.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199007</creationdate><title>Recurrent urticaria and reduced diamine oxidase activity</title><author>LESSOF, M. H. ; GANT, V. ; HINUMA, K. ; MURPHY, G. M. ; DOWLING, R. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5023-fdb71430c6cddfc0fb4148331c116bc7c46417f75c8ef4929c196799c4f2a4c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amine Oxidase (Copper-Containing) - blood</topic><topic>Amine Oxidase (Copper-Containing) - metabolism</topic><topic>Biological and medical sciences</topic><topic>Colic - complications</topic><topic>Female</topic><topic>Heparin - administration & dosage</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Intestinal Mucosa - enzymology</topic><topic>Jejunum - enzymology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Recurrence</topic><topic>Urticaria - complications</topic><topic>Urticaria - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LESSOF, M. H.</creatorcontrib><creatorcontrib>GANT, V.</creatorcontrib><creatorcontrib>HINUMA, K.</creatorcontrib><creatorcontrib>MURPHY, G. M.</creatorcontrib><creatorcontrib>DOWLING, R. H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LESSOF, M. H.</au><au>GANT, V.</au><au>HINUMA, K.</au><au>MURPHY, G. M.</au><au>DOWLING, R. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrent urticaria and reduced diamine oxidase activity</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>1990-07</date><risdate>1990</risdate><volume>20</volume><issue>4</issue><spage>373</spage><epage>376</epage><pages>373-376</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Summary
An abnormal metabolism of histamine has been suspected in urticaria and the role of diamine oxidase (DAO; histaminase) is therefore of interest. We have studied DAO activity in plasma and jejunal biopsy material and have measured the post‐heparin DAO release in 11 control subjects and nine with recurrent urticaria, three of whom had had concurrent episodes of abdominal pain. Two of the nine urticaria subjects had only a minimal rise in plasma DAO activity after heparin, three had a response which was at the lower end of the normal range, and four were normal. In four out of five cases in which jejunal biopsy activity was obtained, there was concordance between mucosal DAO activity and the post‐heparin plasma DAO response. Those with abdominal symptoms had abnormally low mucosal DAO activity and the subject who was most severely affected had proven episodes of small bowel oedema.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2115815</pmid><doi>10.1111/j.1365-2222.1990.tb02796.x</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0954-7894 |
| ispartof | Clinical and experimental allergy, 1990-07, Vol.20 (4), p.373-376 |
| issn | 0954-7894 1365-2222 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Amine Oxidase (Copper-Containing) - blood Amine Oxidase (Copper-Containing) - metabolism Biological and medical sciences Colic - complications Female Heparin - administration & dosage Humans Immunopathology Intestinal Mucosa - enzymology Jejunum - enzymology Male Medical sciences Middle Aged Recurrence Urticaria - complications Urticaria - enzymology |
| title | Recurrent urticaria and reduced diamine oxidase activity |
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