The mode of presentation and route of administration are critical for the induction of immune responses to p53 and antitumor immunity

We have examined the immune response to full-length wild-type human p53 presented by a recombinant canarypox vector (ALVAC) and by plasmid DNA. For the ALVAC recombinant, intravenous, but not subcutaneous, intramuscular or intradermal administration, induced CD8 + CTLs that lysed tumor cells transfe...

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Veröffentlicht in:	Vaccine 1998-01, Vol.16 (2), p.208-215
Hauptverfasser:	Hurpin, Christian, Rotarioa, Chantal, Bisceglia, Hélène, Chevalier, Michel, Tartaglia, James, Erdile, Lorne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cancer Vaccines - administration & dosage Cancer Vaccines - immunology CTL Drug Administration Routes Drug Carriers Female Immunization Immunotherapy Medical sciences Mice Mice, Inbred BALB C Mice, Inbred DBA Pharmacology. Drug treatments Recombinant Proteins - administration & dosage Tumor Suppressor Protein p53 - administration & dosage Tumor Suppressor Protein p53 - immunology tumor-associated antigen vaccination Vaccines, DNA - administration & dosage
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