Effects of JTE-522, a specific inhibitor of cyclooxygenase-2, on the recurrence of allergic inflammation in rats

JTE-522, 4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide, is a selective inhibitor of cyclooxygenase-2 at the enzyme level (IC 50 is 6.4×10 −7 M for sheep cyclooxygenase-2, but it does not inhibit sheep cyclooxygenase-1 at concentrations up to 10 −4 M). In rat peritoneal macrophages...

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