Primary and Recurrent Herpes Simplex Virus Type 2-Induced Meningitis
In 27 patients with a first episode of herpes simplex virus type 2 (HSV-2)-induced meningitis, confirmed by virus isolation from the cerebrospinal fluid (CSF) or seroconversion to HSV-2, initial neurologic complications were found in 10 (37%) but subsided before 6 months in all patients. Long-term c...
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| Veröffentlicht in: | The Journal of infectious diseases 1990-08, Vol.162 (2), p.322-330 |
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| container_title | The Journal of infectious diseases |
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| creator | Bergström, Tomas Vahlne, Anders lestig, Kjell Jeansson, Stig Forsgren, Marianne Lycke, Erik |
| description | In 27 patients with a first episode of herpes simplex virus type 2 (HSV-2)-induced meningitis, confirmed by virus isolation from the cerebrospinal fluid (CSF) or seroconversion to HSV-2, initial neurologic complications were found in 10 (37%) but subsided before 6 months in all patients. Long-term complications were recurrent meningitis in 5 (19%) and periodic headache related to genital HSV recrudescences in 4 (15%). Seven additional patients had possible HSV2- induced recurrent meningitis. In contrast to the first episode of meningitis, virus isolation, HSV antigen detection, and IgG analyses in consecutive serum samples were of no diagnostic value in episodes of HSV-2-induced recurrent meningitis. Instead, immunoblotting was used to assay intrathecally produced IgG antibodies to the HSV-2 type-specific protein gG-2 in recurrent meningitis, when CSF was collected at a minimum of 3 days after onset. |
| doi_str_mv | 10.1093/infdis/162.2.322 |
| format | Article |
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Long-term complications were recurrent meningitis in 5 (19%) and periodic headache related to genital HSV recrudescences in 4 (15%). Seven additional patients had possible HSV2- induced recurrent meningitis. In contrast to the first episode of meningitis, virus isolation, HSV antigen detection, and IgG analyses in consecutive serum samples were of no diagnostic value in episodes of HSV-2-induced recurrent meningitis. 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Long-term complications were recurrent meningitis in 5 (19%) and periodic headache related to genital HSV recrudescences in 4 (15%). Seven additional patients had possible HSV2- induced recurrent meningitis. In contrast to the first episode of meningitis, virus isolation, HSV antigen detection, and IgG analyses in consecutive serum samples were of no diagnostic value in episodes of HSV-2-induced recurrent meningitis. Instead, immunoblotting was used to assay intrathecally produced IgG antibodies to the HSV-2 type-specific protein gG-2 in recurrent meningitis, when CSF was collected at a minimum of 3 days after onset.</description><subject>Antibodies</subject><subject>Antibodies, Viral - analysis</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Cerebrospinal Fluid - cytology</subject><subject>Cerebrospinal Fluid - microbiology</subject><subject>Enzyme linked immunosorbent assay</subject><subject>Female</subject><subject>Genitalia</subject><subject>Herpes Simplex - cerebrospinal fluid</subject><subject>Herpes Simplex - complications</subject><subject>Herpes Simplex - immunology</subject><subject>Human herpesvirus 2</subject><subject>Humans</subject><subject>Immunoglobulin G - analysis</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Lesions</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meningitis, Viral - cerebrospinal fluid</subject><subject>Meningitis, Viral - complications</subject><subject>Meningitis, Viral - immunology</subject><subject>Middle Aged</subject><subject>Nervous System Diseases - etiology</subject><subject>Recurrence</subject><subject>Simplexvirus</subject><subject>Simplexvirus - immunology</subject><subject>Simplexvirus - isolation & purification</subject><subject>Viral diseases</subject><subject>Viral meningitis</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9P3DAQhS1UBFvKvRekHKrestjjOGMfK1pYJKCo5Zd6sbzOBBmy2dROJPjvmzbbVW89zeF770nzMfZe8LngRh6Htq5COhYlzGEuAXbYTCiJeVkK-YbNOAfIhTZmn71N6YlzXsgS99geiFIJrmbs83UMKxdfM9dW2TfyQ4zU9tmCYkcp-x5WXUMv2V2IQ8puXjvKID9vq8FTlV1SG9rH0If0ju3Wrkl0uLkH7Pb0y83JIr_4enZ-8uki94Uo-txwJO9MXQIteV3yJXlRmBqM8FjJQhWONFaCls4Zj7UHzdGgUwgIhKTkAfs47XZx_XOg1NtVSJ6axrW0HpJFo41Ejf8NCqW1kFqPQT4FfVynFKm23eTDCm5_G7aTYTsatmBHw2PlaLM9LFdUbQsbpSP_sOEuedfU0bV-HPgbUwrGr_6ZeUr9Om6x5AIk_8PziYfU08uWu_hsS5So7OLhh8Xi-ur-7ArsqfwFPW6c9g</recordid><startdate>19900801</startdate><enddate>19900801</enddate><creator>Bergström, Tomas</creator><creator>Vahlne, Anders</creator><creator>lestig, Kjell</creator><creator>Jeansson, Stig</creator><creator>Forsgren, Marianne</creator><creator>Lycke, Erik</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19900801</creationdate><title>Primary and Recurrent Herpes Simplex Virus Type 2-Induced Meningitis</title><author>Bergström, Tomas ; 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| subjects | Antibodies Antibodies, Viral - analysis Antigens Biological and medical sciences Cerebrospinal Fluid - cytology Cerebrospinal Fluid - microbiology Enzyme linked immunosorbent assay Female Genitalia Herpes Simplex - cerebrospinal fluid Herpes Simplex - complications Herpes Simplex - immunology Human herpesvirus 2 Humans Immunoglobulin G - analysis Infections Infectious diseases Lesions Major Articles Male Medical sciences Meningitis, Viral - cerebrospinal fluid Meningitis, Viral - complications Meningitis, Viral - immunology Middle Aged Nervous System Diseases - etiology Recurrence Simplexvirus Simplexvirus - immunology Simplexvirus - isolation & purification Viral diseases Viral meningitis Viruses |
| title | Primary and Recurrent Herpes Simplex Virus Type 2-Induced Meningitis |
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