Studies on mast cells and histamine release in psoriasis : The effect of ranitidine
The purpose of this study was to investigate histamine and skin mast cells in psoriasis before and during 6 months of treatment with high-dose ranitidine. Sixteen psoriasis patients, presenting a mean PASI score of 15.4, were compared with 13 age- and sex-matched healthy controls. Resting extracellu...
Gespeichert in:
| Veröffentlicht in: | Acta dermato-venereologica 1998-05, Vol.78 (3), p.190-193 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 193 |
|---|---|
| container_issue | 3 |
| container_start_page | 190 |
| container_title | Acta dermato-venereologica |
| container_volume | 78 |
| creator | PETERSEN, L. J HANSEN, U KRISTENSEN, J. K NIELSEN, H SKOV, P. S NIELSEN, H. J |
| description | The purpose of this study was to investigate histamine and skin mast cells in psoriasis before and during 6 months of treatment with high-dose ranitidine. Sixteen psoriasis patients, presenting a mean PASI score of 15.4, were compared with 13 age- and sex-matched healthy controls. Resting extracellular skin levels of histamine and histamine release to mast cell secretagogues, as measured by the microdialysis technique, were increased in involved psoriasis skin compared to normal skin in the controls. Plasma histamine, but not basophil histamine release, was significantly increased in the patients. Mast cells and lymphocytes were significantly increased in numbers in involved versus non-involved skin in the patients, the lymphocytes being predominantly T-lymphocytes expressing HLA-DR activation. During 6 months of ranitidine treatment, mean PASI score of 15.4 decreased to 5.8. The lymphocyte infiltration, but not mast cell numbers, was significantly reduced during treatment, and histamine release to mast cell secretagogues was normalized. These observations suggest that skin mast cells in active psoriasis are functionally hyperreactive. The biochemical findings together with the clinical effect of ranitidine indicate that histamine may be involved in the pathophysiology of psoriasis. |
| doi_str_mv | 10.1080/000155598441503 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79893721</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79893721</sourcerecordid><originalsourceid>FETCH-LOGICAL-c457t-b35418b789c282c907638e39c739d977eae711e5a8943c7ee1c6037ad5b490023</originalsourceid><addsrcrecordid>eNpdkL1PwzAQxS0EKqUwMyF5QGyh_ohjmw1VfEmVGFrmyHEuqlE-Si4Z-O9x1agD0-n0fvd07xFyy9kjZ4YtGWNcKWVNmnLF5BmZ80zxRDClz8n8oCZRVpfkCvE7rkJxMyMzmzEhRDonm80wlgGQdi1tHA7UQ10jdW1JdwEH14QWaA81OAQaWrrHrg8OA9Inut0BhaoCP9Cuor1rwxDKyF-Ti8rVCDfTXJCv15ft6j1Zf759rJ7XiU-VHpJCqpSbQhvrhRHeMp1JA9J6LW1ptQYHmnNQzthUeg3AfcakdqUqUhuTyAV5OPru--5nBBzyJuDhf9dCN2KurbFSCx7B5RH0fYfYQ5Xv-9C4_jfnLD_UmP-rMV7cTdZj0UB54qfeon4_6Q69q6sY3gc8YZFRmc3kH19od78</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79893721</pqid></control><display><type>article</type><title>Studies on mast cells and histamine release in psoriasis : The effect of ranitidine</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>PETERSEN, L. J ; HANSEN, U ; KRISTENSEN, J. K ; NIELSEN, H ; SKOV, P. S ; NIELSEN, H. J</creator><creatorcontrib>PETERSEN, L. J ; HANSEN, U ; KRISTENSEN, J. K ; NIELSEN, H ; SKOV, P. S ; NIELSEN, H. J</creatorcontrib><description>The purpose of this study was to investigate histamine and skin mast cells in psoriasis before and during 6 months of treatment with high-dose ranitidine. Sixteen psoriasis patients, presenting a mean PASI score of 15.4, were compared with 13 age- and sex-matched healthy controls. Resting extracellular skin levels of histamine and histamine release to mast cell secretagogues, as measured by the microdialysis technique, were increased in involved psoriasis skin compared to normal skin in the controls. Plasma histamine, but not basophil histamine release, was significantly increased in the patients. Mast cells and lymphocytes were significantly increased in numbers in involved versus non-involved skin in the patients, the lymphocytes being predominantly T-lymphocytes expressing HLA-DR activation. During 6 months of ranitidine treatment, mean PASI score of 15.4 decreased to 5.8. The lymphocyte infiltration, but not mast cell numbers, was significantly reduced during treatment, and histamine release to mast cell secretagogues was normalized. These observations suggest that skin mast cells in active psoriasis are functionally hyperreactive. The biochemical findings together with the clinical effect of ranitidine indicate that histamine may be involved in the pathophysiology of psoriasis.</description><identifier>ISSN: 0001-5555</identifier><identifier>EISSN: 1651-2057</identifier><identifier>DOI: 10.1080/000155598441503</identifier><identifier>PMID: 9602224</identifier><identifier>CODEN: ADVEA4</identifier><language>eng</language><publisher>Uppsala: Acta dermato-venereologica</publisher><subject>AIDS/HIV ; Biological and medical sciences ; Case-Control Studies ; CD4-CD8 Ratio ; Dermatology ; Female ; Histamine - analysis ; Histamine H2 Antagonists - administration & dosage ; Histamine H2 Antagonists - therapeutic use ; Histamine Release - physiology ; Humans ; Immunohistochemistry ; Male ; Mast Cells - cytology ; Mast Cells - metabolism ; Medical sciences ; Pharmacology. Drug treatments ; Psoriasis - drug therapy ; Psoriasis - immunology ; Psoriasis - pathology ; Psoriasis. Parapsoriasis. Lichen ; Ranitidine - administration & dosage ; Ranitidine - therapeutic use ; Severity of Illness Index ; Skin - cytology ; Skin - drug effects ; Skin - pathology ; Skin, nail, hair, dermoskeleton ; T-Lymphocytes - chemistry ; T-Lymphocytes - immunology ; Treatment Outcome</subject><ispartof>Acta dermato-venereologica, 1998-05, Vol.78 (3), p.190-193</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-b35418b789c282c907638e39c739d977eae711e5a8943c7ee1c6037ad5b490023</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2225696$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9602224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PETERSEN, L. J</creatorcontrib><creatorcontrib>HANSEN, U</creatorcontrib><creatorcontrib>KRISTENSEN, J. K</creatorcontrib><creatorcontrib>NIELSEN, H</creatorcontrib><creatorcontrib>SKOV, P. S</creatorcontrib><creatorcontrib>NIELSEN, H. J</creatorcontrib><title>Studies on mast cells and histamine release in psoriasis : The effect of ranitidine</title><title>Acta dermato-venereologica</title><addtitle>Acta Derm Venereol</addtitle><description>The purpose of this study was to investigate histamine and skin mast cells in psoriasis before and during 6 months of treatment with high-dose ranitidine. Sixteen psoriasis patients, presenting a mean PASI score of 15.4, were compared with 13 age- and sex-matched healthy controls. Resting extracellular skin levels of histamine and histamine release to mast cell secretagogues, as measured by the microdialysis technique, were increased in involved psoriasis skin compared to normal skin in the controls. Plasma histamine, but not basophil histamine release, was significantly increased in the patients. Mast cells and lymphocytes were significantly increased in numbers in involved versus non-involved skin in the patients, the lymphocytes being predominantly T-lymphocytes expressing HLA-DR activation. During 6 months of ranitidine treatment, mean PASI score of 15.4 decreased to 5.8. The lymphocyte infiltration, but not mast cell numbers, was significantly reduced during treatment, and histamine release to mast cell secretagogues was normalized. These observations suggest that skin mast cells in active psoriasis are functionally hyperreactive. The biochemical findings together with the clinical effect of ranitidine indicate that histamine may be involved in the pathophysiology of psoriasis.</description><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>CD4-CD8 Ratio</subject><subject>Dermatology</subject><subject>Female</subject><subject>Histamine - analysis</subject><subject>Histamine H2 Antagonists - administration & dosage</subject><subject>Histamine H2 Antagonists - therapeutic use</subject><subject>Histamine Release - physiology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Mast Cells - cytology</subject><subject>Mast Cells - metabolism</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Psoriasis - drug therapy</subject><subject>Psoriasis - immunology</subject><subject>Psoriasis - pathology</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Ranitidine - administration & dosage</subject><subject>Ranitidine - therapeutic use</subject><subject>Severity of Illness Index</subject><subject>Skin - cytology</subject><subject>Skin - drug effects</subject><subject>Skin - pathology</subject><subject>Skin, nail, hair, dermoskeleton</subject><subject>T-Lymphocytes - chemistry</subject><subject>T-Lymphocytes - immunology</subject><subject>Treatment Outcome</subject><issn>0001-5555</issn><issn>1651-2057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkL1PwzAQxS0EKqUwMyF5QGyh_ohjmw1VfEmVGFrmyHEuqlE-Si4Z-O9x1agD0-n0fvd07xFyy9kjZ4YtGWNcKWVNmnLF5BmZ80zxRDClz8n8oCZRVpfkCvE7rkJxMyMzmzEhRDonm80wlgGQdi1tHA7UQ10jdW1JdwEH14QWaA81OAQaWrrHrg8OA9Inut0BhaoCP9Cuor1rwxDKyF-Ti8rVCDfTXJCv15ft6j1Zf759rJ7XiU-VHpJCqpSbQhvrhRHeMp1JA9J6LW1ptQYHmnNQzthUeg3AfcakdqUqUhuTyAV5OPru--5nBBzyJuDhf9dCN2KurbFSCx7B5RH0fYfYQ5Xv-9C4_jfnLD_UmP-rMV7cTdZj0UB54qfeon4_6Q69q6sY3gc8YZFRmc3kH19od78</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>PETERSEN, L. J</creator><creator>HANSEN, U</creator><creator>KRISTENSEN, J. K</creator><creator>NIELSEN, H</creator><creator>SKOV, P. S</creator><creator>NIELSEN, H. J</creator><general>Acta dermato-venereologica</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980501</creationdate><title>Studies on mast cells and histamine release in psoriasis : The effect of ranitidine</title><author>PETERSEN, L. J ; HANSEN, U ; KRISTENSEN, J. K ; NIELSEN, H ; SKOV, P. S ; NIELSEN, H. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-b35418b789c282c907638e39c739d977eae711e5a8943c7ee1c6037ad5b490023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>CD4-CD8 Ratio</topic><topic>Dermatology</topic><topic>Female</topic><topic>Histamine - analysis</topic><topic>Histamine H2 Antagonists - administration & dosage</topic><topic>Histamine H2 Antagonists - therapeutic use</topic><topic>Histamine Release - physiology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Mast Cells - cytology</topic><topic>Mast Cells - metabolism</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Psoriasis - drug therapy</topic><topic>Psoriasis - immunology</topic><topic>Psoriasis - pathology</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Ranitidine - administration & dosage</topic><topic>Ranitidine - therapeutic use</topic><topic>Severity of Illness Index</topic><topic>Skin - cytology</topic><topic>Skin - drug effects</topic><topic>Skin - pathology</topic><topic>Skin, nail, hair, dermoskeleton</topic><topic>T-Lymphocytes - chemistry</topic><topic>T-Lymphocytes - immunology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PETERSEN, L. J</creatorcontrib><creatorcontrib>HANSEN, U</creatorcontrib><creatorcontrib>KRISTENSEN, J. K</creatorcontrib><creatorcontrib>NIELSEN, H</creatorcontrib><creatorcontrib>SKOV, P. S</creatorcontrib><creatorcontrib>NIELSEN, H. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta dermato-venereologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PETERSEN, L. J</au><au>HANSEN, U</au><au>KRISTENSEN, J. K</au><au>NIELSEN, H</au><au>SKOV, P. S</au><au>NIELSEN, H. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on mast cells and histamine release in psoriasis : The effect of ranitidine</atitle><jtitle>Acta dermato-venereologica</jtitle><addtitle>Acta Derm Venereol</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>78</volume><issue>3</issue><spage>190</spage><epage>193</epage><pages>190-193</pages><issn>0001-5555</issn><eissn>1651-2057</eissn><coden>ADVEA4</coden><abstract>The purpose of this study was to investigate histamine and skin mast cells in psoriasis before and during 6 months of treatment with high-dose ranitidine. Sixteen psoriasis patients, presenting a mean PASI score of 15.4, were compared with 13 age- and sex-matched healthy controls. Resting extracellular skin levels of histamine and histamine release to mast cell secretagogues, as measured by the microdialysis technique, were increased in involved psoriasis skin compared to normal skin in the controls. Plasma histamine, but not basophil histamine release, was significantly increased in the patients. Mast cells and lymphocytes were significantly increased in numbers in involved versus non-involved skin in the patients, the lymphocytes being predominantly T-lymphocytes expressing HLA-DR activation. During 6 months of ranitidine treatment, mean PASI score of 15.4 decreased to 5.8. The lymphocyte infiltration, but not mast cell numbers, was significantly reduced during treatment, and histamine release to mast cell secretagogues was normalized. These observations suggest that skin mast cells in active psoriasis are functionally hyperreactive. The biochemical findings together with the clinical effect of ranitidine indicate that histamine may be involved in the pathophysiology of psoriasis.</abstract><cop>Uppsala</cop><pub>Acta dermato-venereologica</pub><pmid>9602224</pmid><doi>10.1080/000155598441503</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-5555 |
| ispartof | Acta dermato-venereologica, 1998-05, Vol.78 (3), p.190-193 |
| issn | 0001-5555 1651-2057 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79893721 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | AIDS/HIV Biological and medical sciences Case-Control Studies CD4-CD8 Ratio Dermatology Female Histamine - analysis Histamine H2 Antagonists - administration & dosage Histamine H2 Antagonists - therapeutic use Histamine Release - physiology Humans Immunohistochemistry Male Mast Cells - cytology Mast Cells - metabolism Medical sciences Pharmacology. Drug treatments Psoriasis - drug therapy Psoriasis - immunology Psoriasis - pathology Psoriasis. Parapsoriasis. Lichen Ranitidine - administration & dosage Ranitidine - therapeutic use Severity of Illness Index Skin - cytology Skin - drug effects Skin - pathology Skin, nail, hair, dermoskeleton T-Lymphocytes - chemistry T-Lymphocytes - immunology Treatment Outcome |
| title | Studies on mast cells and histamine release in psoriasis : The effect of ranitidine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T05%3A28%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Studies%20on%20mast%20cells%20and%20histamine%20release%20in%20psoriasis%20:%20The%20effect%20of%20ranitidine&rft.jtitle=Acta%20dermato-venereologica&rft.au=PETERSEN,%20L.%20J&rft.date=1998-05-01&rft.volume=78&rft.issue=3&rft.spage=190&rft.epage=193&rft.pages=190-193&rft.issn=0001-5555&rft.eissn=1651-2057&rft.coden=ADVEA4&rft_id=info:doi/10.1080/000155598441503&rft_dat=%3Cproquest_cross%3E79893721%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79893721&rft_id=info:pmid/9602224&rfr_iscdi=true |