Altered Allelic Distributions of the Serotonin Transporter Gene in Migraine Without Aura and Migraine with Aura
Allelic variation of the human serotonin transporter gene (HSERT), a highly plausible candidate gene for susceptibility to migraine, was investigated in 266 individuals with migraine, including 173 having migraine without aura (MO), 94 having migraine with aura (MA), 18 with co-occurrence of MO and...
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Veröffentlicht in: | Cephalalgia 1998-01, Vol.18 (1), p.23-26 |
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description | Allelic variation of the human serotonin transporter gene (HSERT), a highly plausible candidate gene for susceptibility to migraine, was investigated in 266 individuals with migraine, including 173 having migraine without aura (MO), 94 having migraine with aura (MA), 18 with co-occurrence of MO and MA, plus 133 unaffected controls. The distribution of a polymorphism with different forms of a variable tandem number repeat (VNTR) in intron 2 were compared. The MO group had an over-representation of genotypes with two twelve repeat alleles (STin2.12) and a reduction of genotypes containing one ten repeat (STin2.10) compared to controls. The MA group showed a similar pattern, but also a trend towards an increase in genotypes containing the nine repeat allele of the VNTR (STin2.9). Genotypes containing this allele were found in 6.4% of the MA group compared to 2.3% of controls. The group with co-occurrence of MO and MA had a significantly different pattern of overall allele frequency distribution from controls, reflecting a reduction in genotypes containing the STin2.10 allele and a shift both to STin2.9 carriers and to STin2.12 homozygosity. These results support the view that susceptibility to MO and MA has a genetic component, that these disorders are distinct, and that genetic susceptibility may in some cases be associated with a locus at or near the serotonin transporter gene. |
doi_str_mv | 10.1046/j.1468-2982.1998.1801023.x |
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The distribution of a polymorphism with different forms of a variable tandem number repeat (VNTR) in intron 2 were compared. The MO group had an over-representation of genotypes with two twelve repeat alleles (STin2.12) and a reduction of genotypes containing one ten repeat (STin2.10) compared to controls. The MA group showed a similar pattern, but also a trend towards an increase in genotypes containing the nine repeat allele of the VNTR (STin2.9). Genotypes containing this allele were found in 6.4% of the MA group compared to 2.3% of controls. The group with co-occurrence of MO and MA had a significantly different pattern of overall allele frequency distribution from controls, reflecting a reduction in genotypes containing the STin2.10 allele and a shift both to STin2.9 carriers and to STin2.12 homozygosity. These results support the view that susceptibility to MO and MA has a genetic component, that these disorders are distinct, and that genetic susceptibility may in some cases be associated with a locus at or near the serotonin transporter gene.</description><identifier>ISSN: 0333-1024</identifier><identifier>EISSN: 1468-2982</identifier><identifier>DOI: 10.1046/j.1468-2982.1998.1801023.x</identifier><identifier>PMID: 9601620</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Alleles ; Carrier Proteins - genetics ; Female ; Genotype ; Humans ; Introns ; Male ; Membrane Glycoproteins - genetics ; Membrane Transport Proteins ; Migraine ; Migraine Disorders - classification ; Migraine Disorders - genetics ; Minisatellite Repeats ; Nerve Tissue Proteins ; Polymorphism, Genetic - genetics ; Serotonin Plasma Membrane Transport Proteins ; serotonin transporter</subject><ispartof>Cephalalgia, 1998-01, Vol.18 (1), p.23-26</ispartof><rights>1998 International Headache Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4223-6c73c12582b5f5303cf15eef6482a058e03283a10bfbf6574e4ccb0f4b0cd0ae3</citedby><cites>FETCH-LOGICAL-c4223-6c73c12582b5f5303cf15eef6482a058e03283a10bfbf6574e4ccb0f4b0cd0ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1046/j.1468-2982.1998.1801023.x$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1046/j.1468-2982.1998.1801023.x$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,1416,21818,27923,27924,43620,43621,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9601620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogilvie, AD</creatorcontrib><creatorcontrib>Russell, MB</creatorcontrib><creatorcontrib>Dhall, P</creatorcontrib><creatorcontrib>Battersby, S</creatorcontrib><creatorcontrib>Ulrich, V</creatorcontrib><creatorcontrib>Smith, CA Dale</creatorcontrib><creatorcontrib>Goodwin, GM</creatorcontrib><creatorcontrib>Harmar, AJ</creatorcontrib><creatorcontrib>Olesen, J</creatorcontrib><title>Altered Allelic Distributions of the Serotonin Transporter Gene in Migraine Without Aura and Migraine with Aura</title><title>Cephalalgia</title><addtitle>Cephalalgia</addtitle><description>Allelic variation of the human serotonin transporter gene (HSERT), a highly plausible candidate gene for susceptibility to migraine, was investigated in 266 individuals with migraine, including 173 having migraine without aura (MO), 94 having migraine with aura (MA), 18 with co-occurrence of MO and MA, plus 133 unaffected controls. The distribution of a polymorphism with different forms of a variable tandem number repeat (VNTR) in intron 2 were compared. The MO group had an over-representation of genotypes with two twelve repeat alleles (STin2.12) and a reduction of genotypes containing one ten repeat (STin2.10) compared to controls. The MA group showed a similar pattern, but also a trend towards an increase in genotypes containing the nine repeat allele of the VNTR (STin2.9). Genotypes containing this allele were found in 6.4% of the MA group compared to 2.3% of controls. The group with co-occurrence of MO and MA had a significantly different pattern of overall allele frequency distribution from controls, reflecting a reduction in genotypes containing the STin2.10 allele and a shift both to STin2.9 carriers and to STin2.12 homozygosity. These results support the view that susceptibility to MO and MA has a genetic component, that these disorders are distinct, and that genetic susceptibility may in some cases be associated with a locus at or near the serotonin transporter gene.</description><subject>Adult</subject><subject>Alleles</subject><subject>Carrier Proteins - genetics</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Introns</subject><subject>Male</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Transport Proteins</subject><subject>Migraine</subject><subject>Migraine Disorders - classification</subject><subject>Migraine Disorders - genetics</subject><subject>Minisatellite Repeats</subject><subject>Nerve Tissue Proteins</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Serotonin Plasma Membrane Transport Proteins</subject><subject>serotonin transporter</subject><issn>0333-1024</issn><issn>1468-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMFO3DAQhi1URBfoIyBZPfSWdGwnXqe31UKhEhVIgHq0HO8YvMrGWzsR8Pb1shG9tifb8838Y32EfGZQMqjk13XJKqkK3ihesqZRJVPAgIvy5YDM3tEHMgMhRJFJ9ZEcp7QGgFqCPCJHjQQmOcxIWHQDRlzRRddh5y0992mIvh0HH_pEg6PDE9I7jGEIve_pfTR92oaYh-gl9khz7ad_jMbn-y8_PIVxoIsxGmr61V_ynMlb-ZQcOtMl_DSdJ-Th-8X98qq4vrn8sVxcF7biXBTSzoVlvFa8rV0tQFjHakQnK8UN1ApBcCUMg9a1TtbzCitrW3BVC3YFBsUJ-bLP3cbwe8Q06I1PFrvO9BjGpOeNaoQUPDd-2zfaGFKK6PQ2-o2Jr5qB3tnWa71TqndK9c62nmzrlzx8Nm0Z2w2u3kcnvZkv9_zZd_j6H8l6eXF7Nb1yynyfkswj6nUYY5_V_cv__gDawqDL</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Ogilvie, AD</creator><creator>Russell, MB</creator><creator>Dhall, P</creator><creator>Battersby, S</creator><creator>Ulrich, V</creator><creator>Smith, CA Dale</creator><creator>Goodwin, GM</creator><creator>Harmar, AJ</creator><creator>Olesen, J</creator><general>SAGE Publications</general><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199801</creationdate><title>Altered Allelic Distributions of the Serotonin Transporter Gene in Migraine Without Aura and Migraine with Aura</title><author>Ogilvie, AD ; Russell, MB ; Dhall, P ; Battersby, S ; Ulrich, V ; Smith, CA Dale ; Goodwin, GM ; Harmar, AJ ; Olesen, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4223-6c73c12582b5f5303cf15eef6482a058e03283a10bfbf6574e4ccb0f4b0cd0ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Carrier Proteins - genetics</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Introns</topic><topic>Male</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Transport Proteins</topic><topic>Migraine</topic><topic>Migraine Disorders - classification</topic><topic>Migraine Disorders - genetics</topic><topic>Minisatellite Repeats</topic><topic>Nerve Tissue Proteins</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Serotonin Plasma Membrane Transport Proteins</topic><topic>serotonin transporter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogilvie, AD</creatorcontrib><creatorcontrib>Russell, MB</creatorcontrib><creatorcontrib>Dhall, P</creatorcontrib><creatorcontrib>Battersby, S</creatorcontrib><creatorcontrib>Ulrich, V</creatorcontrib><creatorcontrib>Smith, CA Dale</creatorcontrib><creatorcontrib>Goodwin, GM</creatorcontrib><creatorcontrib>Harmar, AJ</creatorcontrib><creatorcontrib>Olesen, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cephalalgia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogilvie, AD</au><au>Russell, MB</au><au>Dhall, P</au><au>Battersby, S</au><au>Ulrich, V</au><au>Smith, CA Dale</au><au>Goodwin, GM</au><au>Harmar, AJ</au><au>Olesen, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered Allelic Distributions of the Serotonin Transporter Gene in Migraine Without Aura and Migraine with Aura</atitle><jtitle>Cephalalgia</jtitle><addtitle>Cephalalgia</addtitle><date>1998-01</date><risdate>1998</risdate><volume>18</volume><issue>1</issue><spage>23</spage><epage>26</epage><pages>23-26</pages><issn>0333-1024</issn><eissn>1468-2982</eissn><abstract>Allelic variation of the human serotonin transporter gene (HSERT), a highly plausible candidate gene for susceptibility to migraine, was investigated in 266 individuals with migraine, including 173 having migraine without aura (MO), 94 having migraine with aura (MA), 18 with co-occurrence of MO and MA, plus 133 unaffected controls. The distribution of a polymorphism with different forms of a variable tandem number repeat (VNTR) in intron 2 were compared. The MO group had an over-representation of genotypes with two twelve repeat alleles (STin2.12) and a reduction of genotypes containing one ten repeat (STin2.10) compared to controls. The MA group showed a similar pattern, but also a trend towards an increase in genotypes containing the nine repeat allele of the VNTR (STin2.9). Genotypes containing this allele were found in 6.4% of the MA group compared to 2.3% of controls. The group with co-occurrence of MO and MA had a significantly different pattern of overall allele frequency distribution from controls, reflecting a reduction in genotypes containing the STin2.10 allele and a shift both to STin2.9 carriers and to STin2.12 homozygosity. These results support the view that susceptibility to MO and MA has a genetic component, that these disorders are distinct, and that genetic susceptibility may in some cases be associated with a locus at or near the serotonin transporter gene.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>9601620</pmid><doi>10.1046/j.1468-2982.1998.1801023.x</doi><tpages>4</tpages></addata></record> |
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subjects | Adult Alleles Carrier Proteins - genetics Female Genotype Humans Introns Male Membrane Glycoproteins - genetics Membrane Transport Proteins Migraine Migraine Disorders - classification Migraine Disorders - genetics Minisatellite Repeats Nerve Tissue Proteins Polymorphism, Genetic - genetics Serotonin Plasma Membrane Transport Proteins serotonin transporter |
title | Altered Allelic Distributions of the Serotonin Transporter Gene in Migraine Without Aura and Migraine with Aura |
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