Altered Allelic Distributions of the Serotonin Transporter Gene in Migraine Without Aura and Migraine with Aura

Allelic variation of the human serotonin transporter gene (HSERT), a highly plausible candidate gene for susceptibility to migraine, was investigated in 266 individuals with migraine, including 173 having migraine without aura (MO), 94 having migraine with aura (MA), 18 with co-occurrence of MO and...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cephalalgia 1998-01, Vol.18 (1), p.23-26
Hauptverfasser: Ogilvie, AD, Russell, MB, Dhall, P, Battersby, S, Ulrich, V, Smith, CA Dale, Goodwin, GM, Harmar, AJ, Olesen, J
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 26
container_issue 1
container_start_page 23
container_title Cephalalgia
container_volume 18
creator Ogilvie, AD
Russell, MB
Dhall, P
Battersby, S
Ulrich, V
Smith, CA Dale
Goodwin, GM
Harmar, AJ
Olesen, J
description Allelic variation of the human serotonin transporter gene (HSERT), a highly plausible candidate gene for susceptibility to migraine, was investigated in 266 individuals with migraine, including 173 having migraine without aura (MO), 94 having migraine with aura (MA), 18 with co-occurrence of MO and MA, plus 133 unaffected controls. The distribution of a polymorphism with different forms of a variable tandem number repeat (VNTR) in intron 2 were compared. The MO group had an over-representation of genotypes with two twelve repeat alleles (STin2.12) and a reduction of genotypes containing one ten repeat (STin2.10) compared to controls. The MA group showed a similar pattern, but also a trend towards an increase in genotypes containing the nine repeat allele of the VNTR (STin2.9). Genotypes containing this allele were found in 6.4% of the MA group compared to 2.3% of controls. The group with co-occurrence of MO and MA had a significantly different pattern of overall allele frequency distribution from controls, reflecting a reduction in genotypes containing the STin2.10 allele and a shift both to STin2.9 carriers and to STin2.12 homozygosity. These results support the view that susceptibility to MO and MA has a genetic component, that these disorders are distinct, and that genetic susceptibility may in some cases be associated with a locus at or near the serotonin transporter gene.
doi_str_mv 10.1046/j.1468-2982.1998.1801023.x
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79893632</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1046_j.1468-2982.1998.1801023.x</sage_id><sourcerecordid>79893632</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4223-6c73c12582b5f5303cf15eef6482a058e03283a10bfbf6574e4ccb0f4b0cd0ae3</originalsourceid><addsrcrecordid>eNqVkMFO3DAQhi1URBfoIyBZPfSWdGwnXqe31UKhEhVIgHq0HO8YvMrGWzsR8Pb1shG9tifb8838Y32EfGZQMqjk13XJKqkK3ihesqZRJVPAgIvy5YDM3tEHMgMhRJFJ9ZEcp7QGgFqCPCJHjQQmOcxIWHQDRlzRRddh5y0992mIvh0HH_pEg6PDE9I7jGEIve_pfTR92oaYh-gl9khz7ad_jMbn-y8_PIVxoIsxGmr61V_ynMlb-ZQcOtMl_DSdJ-Th-8X98qq4vrn8sVxcF7biXBTSzoVlvFa8rV0tQFjHakQnK8UN1ApBcCUMg9a1TtbzCitrW3BVC3YFBsUJ-bLP3cbwe8Q06I1PFrvO9BjGpOeNaoQUPDd-2zfaGFKK6PQ2-o2Jr5qB3tnWa71TqndK9c62nmzrlzx8Nm0Z2w2u3kcnvZkv9_zZd_j6H8l6eXF7Nb1yynyfkswj6nUYY5_V_cv__gDawqDL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79893632</pqid></control><display><type>article</type><title>Altered Allelic Distributions of the Serotonin Transporter Gene in Migraine Without Aura and Migraine with Aura</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><source>Wiley Online Library All Journals</source><creator>Ogilvie, AD ; Russell, MB ; Dhall, P ; Battersby, S ; Ulrich, V ; Smith, CA Dale ; Goodwin, GM ; Harmar, AJ ; Olesen, J</creator><creatorcontrib>Ogilvie, AD ; Russell, MB ; Dhall, P ; Battersby, S ; Ulrich, V ; Smith, CA Dale ; Goodwin, GM ; Harmar, AJ ; Olesen, J</creatorcontrib><description>Allelic variation of the human serotonin transporter gene (HSERT), a highly plausible candidate gene for susceptibility to migraine, was investigated in 266 individuals with migraine, including 173 having migraine without aura (MO), 94 having migraine with aura (MA), 18 with co-occurrence of MO and MA, plus 133 unaffected controls. The distribution of a polymorphism with different forms of a variable tandem number repeat (VNTR) in intron 2 were compared. The MO group had an over-representation of genotypes with two twelve repeat alleles (STin2.12) and a reduction of genotypes containing one ten repeat (STin2.10) compared to controls. The MA group showed a similar pattern, but also a trend towards an increase in genotypes containing the nine repeat allele of the VNTR (STin2.9). Genotypes containing this allele were found in 6.4% of the MA group compared to 2.3% of controls. The group with co-occurrence of MO and MA had a significantly different pattern of overall allele frequency distribution from controls, reflecting a reduction in genotypes containing the STin2.10 allele and a shift both to STin2.9 carriers and to STin2.12 homozygosity. These results support the view that susceptibility to MO and MA has a genetic component, that these disorders are distinct, and that genetic susceptibility may in some cases be associated with a locus at or near the serotonin transporter gene.</description><identifier>ISSN: 0333-1024</identifier><identifier>EISSN: 1468-2982</identifier><identifier>DOI: 10.1046/j.1468-2982.1998.1801023.x</identifier><identifier>PMID: 9601620</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Alleles ; Carrier Proteins - genetics ; Female ; Genotype ; Humans ; Introns ; Male ; Membrane Glycoproteins - genetics ; Membrane Transport Proteins ; Migraine ; Migraine Disorders - classification ; Migraine Disorders - genetics ; Minisatellite Repeats ; Nerve Tissue Proteins ; Polymorphism, Genetic - genetics ; Serotonin Plasma Membrane Transport Proteins ; serotonin transporter</subject><ispartof>Cephalalgia, 1998-01, Vol.18 (1), p.23-26</ispartof><rights>1998 International Headache Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4223-6c73c12582b5f5303cf15eef6482a058e03283a10bfbf6574e4ccb0f4b0cd0ae3</citedby><cites>FETCH-LOGICAL-c4223-6c73c12582b5f5303cf15eef6482a058e03283a10bfbf6574e4ccb0f4b0cd0ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1046/j.1468-2982.1998.1801023.x$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1046/j.1468-2982.1998.1801023.x$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,1416,21818,27923,27924,43620,43621,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9601620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogilvie, AD</creatorcontrib><creatorcontrib>Russell, MB</creatorcontrib><creatorcontrib>Dhall, P</creatorcontrib><creatorcontrib>Battersby, S</creatorcontrib><creatorcontrib>Ulrich, V</creatorcontrib><creatorcontrib>Smith, CA Dale</creatorcontrib><creatorcontrib>Goodwin, GM</creatorcontrib><creatorcontrib>Harmar, AJ</creatorcontrib><creatorcontrib>Olesen, J</creatorcontrib><title>Altered Allelic Distributions of the Serotonin Transporter Gene in Migraine Without Aura and Migraine with Aura</title><title>Cephalalgia</title><addtitle>Cephalalgia</addtitle><description>Allelic variation of the human serotonin transporter gene (HSERT), a highly plausible candidate gene for susceptibility to migraine, was investigated in 266 individuals with migraine, including 173 having migraine without aura (MO), 94 having migraine with aura (MA), 18 with co-occurrence of MO and MA, plus 133 unaffected controls. The distribution of a polymorphism with different forms of a variable tandem number repeat (VNTR) in intron 2 were compared. The MO group had an over-representation of genotypes with two twelve repeat alleles (STin2.12) and a reduction of genotypes containing one ten repeat (STin2.10) compared to controls. The MA group showed a similar pattern, but also a trend towards an increase in genotypes containing the nine repeat allele of the VNTR (STin2.9). Genotypes containing this allele were found in 6.4% of the MA group compared to 2.3% of controls. The group with co-occurrence of MO and MA had a significantly different pattern of overall allele frequency distribution from controls, reflecting a reduction in genotypes containing the STin2.10 allele and a shift both to STin2.9 carriers and to STin2.12 homozygosity. These results support the view that susceptibility to MO and MA has a genetic component, that these disorders are distinct, and that genetic susceptibility may in some cases be associated with a locus at or near the serotonin transporter gene.</description><subject>Adult</subject><subject>Alleles</subject><subject>Carrier Proteins - genetics</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Introns</subject><subject>Male</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Transport Proteins</subject><subject>Migraine</subject><subject>Migraine Disorders - classification</subject><subject>Migraine Disorders - genetics</subject><subject>Minisatellite Repeats</subject><subject>Nerve Tissue Proteins</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Serotonin Plasma Membrane Transport Proteins</subject><subject>serotonin transporter</subject><issn>0333-1024</issn><issn>1468-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMFO3DAQhi1URBfoIyBZPfSWdGwnXqe31UKhEhVIgHq0HO8YvMrGWzsR8Pb1shG9tifb8838Y32EfGZQMqjk13XJKqkK3ihesqZRJVPAgIvy5YDM3tEHMgMhRJFJ9ZEcp7QGgFqCPCJHjQQmOcxIWHQDRlzRRddh5y0992mIvh0HH_pEg6PDE9I7jGEIve_pfTR92oaYh-gl9khz7ad_jMbn-y8_PIVxoIsxGmr61V_ynMlb-ZQcOtMl_DSdJ-Th-8X98qq4vrn8sVxcF7biXBTSzoVlvFa8rV0tQFjHakQnK8UN1ApBcCUMg9a1TtbzCitrW3BVC3YFBsUJ-bLP3cbwe8Q06I1PFrvO9BjGpOeNaoQUPDd-2zfaGFKK6PQ2-o2Jr5qB3tnWa71TqndK9c62nmzrlzx8Nm0Z2w2u3kcnvZkv9_zZd_j6H8l6eXF7Nb1yynyfkswj6nUYY5_V_cv__gDawqDL</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Ogilvie, AD</creator><creator>Russell, MB</creator><creator>Dhall, P</creator><creator>Battersby, S</creator><creator>Ulrich, V</creator><creator>Smith, CA Dale</creator><creator>Goodwin, GM</creator><creator>Harmar, AJ</creator><creator>Olesen, J</creator><general>SAGE Publications</general><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199801</creationdate><title>Altered Allelic Distributions of the Serotonin Transporter Gene in Migraine Without Aura and Migraine with Aura</title><author>Ogilvie, AD ; Russell, MB ; Dhall, P ; Battersby, S ; Ulrich, V ; Smith, CA Dale ; Goodwin, GM ; Harmar, AJ ; Olesen, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4223-6c73c12582b5f5303cf15eef6482a058e03283a10bfbf6574e4ccb0f4b0cd0ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Carrier Proteins - genetics</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Introns</topic><topic>Male</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Transport Proteins</topic><topic>Migraine</topic><topic>Migraine Disorders - classification</topic><topic>Migraine Disorders - genetics</topic><topic>Minisatellite Repeats</topic><topic>Nerve Tissue Proteins</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Serotonin Plasma Membrane Transport Proteins</topic><topic>serotonin transporter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogilvie, AD</creatorcontrib><creatorcontrib>Russell, MB</creatorcontrib><creatorcontrib>Dhall, P</creatorcontrib><creatorcontrib>Battersby, S</creatorcontrib><creatorcontrib>Ulrich, V</creatorcontrib><creatorcontrib>Smith, CA Dale</creatorcontrib><creatorcontrib>Goodwin, GM</creatorcontrib><creatorcontrib>Harmar, AJ</creatorcontrib><creatorcontrib>Olesen, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cephalalgia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogilvie, AD</au><au>Russell, MB</au><au>Dhall, P</au><au>Battersby, S</au><au>Ulrich, V</au><au>Smith, CA Dale</au><au>Goodwin, GM</au><au>Harmar, AJ</au><au>Olesen, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered Allelic Distributions of the Serotonin Transporter Gene in Migraine Without Aura and Migraine with Aura</atitle><jtitle>Cephalalgia</jtitle><addtitle>Cephalalgia</addtitle><date>1998-01</date><risdate>1998</risdate><volume>18</volume><issue>1</issue><spage>23</spage><epage>26</epage><pages>23-26</pages><issn>0333-1024</issn><eissn>1468-2982</eissn><abstract>Allelic variation of the human serotonin transporter gene (HSERT), a highly plausible candidate gene for susceptibility to migraine, was investigated in 266 individuals with migraine, including 173 having migraine without aura (MO), 94 having migraine with aura (MA), 18 with co-occurrence of MO and MA, plus 133 unaffected controls. The distribution of a polymorphism with different forms of a variable tandem number repeat (VNTR) in intron 2 were compared. The MO group had an over-representation of genotypes with two twelve repeat alleles (STin2.12) and a reduction of genotypes containing one ten repeat (STin2.10) compared to controls. The MA group showed a similar pattern, but also a trend towards an increase in genotypes containing the nine repeat allele of the VNTR (STin2.9). Genotypes containing this allele were found in 6.4% of the MA group compared to 2.3% of controls. The group with co-occurrence of MO and MA had a significantly different pattern of overall allele frequency distribution from controls, reflecting a reduction in genotypes containing the STin2.10 allele and a shift both to STin2.9 carriers and to STin2.12 homozygosity. These results support the view that susceptibility to MO and MA has a genetic component, that these disorders are distinct, and that genetic susceptibility may in some cases be associated with a locus at or near the serotonin transporter gene.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>9601620</pmid><doi>10.1046/j.1468-2982.1998.1801023.x</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0333-1024
ispartof Cephalalgia, 1998-01, Vol.18 (1), p.23-26
issn 0333-1024
1468-2982
language eng
recordid cdi_proquest_miscellaneous_79893632
source MEDLINE; SAGE Complete A-Z List; Wiley Online Library All Journals
subjects Adult
Alleles
Carrier Proteins - genetics
Female
Genotype
Humans
Introns
Male
Membrane Glycoproteins - genetics
Membrane Transport Proteins
Migraine
Migraine Disorders - classification
Migraine Disorders - genetics
Minisatellite Repeats
Nerve Tissue Proteins
Polymorphism, Genetic - genetics
Serotonin Plasma Membrane Transport Proteins
serotonin transporter
title Altered Allelic Distributions of the Serotonin Transporter Gene in Migraine Without Aura and Migraine with Aura
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T14%3A22%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Altered%20Allelic%20Distributions%20of%20the%20Serotonin%20Transporter%20Gene%20in%20Migraine%20Without%20Aura%20and%20Migraine%20with%20Aura&rft.jtitle=Cephalalgia&rft.au=Ogilvie,%20AD&rft.date=1998-01&rft.volume=18&rft.issue=1&rft.spage=23&rft.epage=26&rft.pages=23-26&rft.issn=0333-1024&rft.eissn=1468-2982&rft_id=info:doi/10.1046/j.1468-2982.1998.1801023.x&rft_dat=%3Cproquest_cross%3E79893632%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79893632&rft_id=info:pmid/9601620&rft_sage_id=10.1046_j.1468-2982.1998.1801023.x&rfr_iscdi=true