Coincidence of seminoma and sarcoidosis: A myth or fact?
A patient with a stage II seminoma of the testis was treated with a routine orchidectomy and irradiation. One and a half years later enlarged mediastinal lymph nodes were noted. Additional staging showed no other abnormalities and a media-stinoscopy was performed. The initial histologic examination...
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| Veröffentlicht in: | Annals of oncology 1998-03, Vol.9 (3), p.321-325 |
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| container_title | Annals of oncology |
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| creator | Tjan-Heijnen, V. C. G. Vlasveld, L. Th Pernet, F. P. P. M. Pauwels, P. De Mulder, P. H. M. |
| description | A patient with a stage II seminoma of the testis was treated with a routine orchidectomy and irradiation. One and a half years later enlarged mediastinal lymph nodes were noted. Additional staging showed no other abnormalities and a media-stinoscopy was performed. The initial histologic examination confirmed the clinically suspected diagnosis of sarcoidosis. However, additional immunohistochemical analysis unexpectedly demonstrated that there was also a microscopic relapse of the testis tumor. The literature concerning the co-incidence of non-caseating granulomas and testis tumors is reviewed. It is not clear, whether the granulomas indicate the presence of genuine idiopathic sarcoidosis or whether they reflect a sarcoid-like reaction against tumor antigens. The immunopathogenesis of sarcoid formation and its possible biologic significance in obtaining a spontaneous tumor remission is discussed. |
| doi_str_mv | 10.1023/A:1008220002148 |
| format | Article |
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C. G. ; Vlasveld, L. Th ; Pernet, F. P. P. M. ; Pauwels, P. ; De Mulder, P. H. M.</creator><creatorcontrib>Tjan-Heijnen, V. C. G. ; Vlasveld, L. Th ; Pernet, F. P. P. M. ; Pauwels, P. ; De Mulder, P. H. M.</creatorcontrib><description>A patient with a stage II seminoma of the testis was treated with a routine orchidectomy and irradiation. One and a half years later enlarged mediastinal lymph nodes were noted. Additional staging showed no other abnormalities and a media-stinoscopy was performed. The initial histologic examination confirmed the clinically suspected diagnosis of sarcoidosis. However, additional immunohistochemical analysis unexpectedly demonstrated that there was also a microscopic relapse of the testis tumor. The literature concerning the co-incidence of non-caseating granulomas and testis tumors is reviewed. It is not clear, whether the granulomas indicate the presence of genuine idiopathic sarcoidosis or whether they reflect a sarcoid-like reaction against tumor antigens. The immunopathogenesis of sarcoid formation and its possible biologic significance in obtaining a spontaneous tumor remission is discussed.</description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1023/A:1008220002148</identifier><identifier>PMID: 9602267</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Diagnosis, Differential ; Disease-Free Survival ; germ cell tumors ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Male ; Male genital diseases ; Mediastinal Diseases - pathology ; Mediastinoscopy ; Medical sciences ; Orchiectomy ; sarcoidosis ; Sarcoidosis - complications ; Sarcoidosis - pathology ; Sarcoidosis - therapy ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Seminoma - complications ; Seminoma - secondary ; Seminoma - therapy ; Testicular Neoplasms - complications ; Testicular Neoplasms - pathology ; Testicular Neoplasms - therapy ; Tomography, X-Ray Computed ; Tumors</subject><ispartof>Annals of oncology, 1998-03, Vol.9 (3), p.321-325</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-80c5081ec0d26caa79c8ba3f82de2d80b15ed2072ea3873a41c60df3b26119953</citedby><cites>FETCH-LOGICAL-c446t-80c5081ec0d26caa79c8ba3f82de2d80b15ed2072ea3873a41c60df3b26119953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2227327$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9602267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tjan-Heijnen, V. C. G.</creatorcontrib><creatorcontrib>Vlasveld, L. Th</creatorcontrib><creatorcontrib>Pernet, F. P. P. M.</creatorcontrib><creatorcontrib>Pauwels, P.</creatorcontrib><creatorcontrib>De Mulder, P. H. M.</creatorcontrib><title>Coincidence of seminoma and sarcoidosis: A myth or fact?</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description>A patient with a stage II seminoma of the testis was treated with a routine orchidectomy and irradiation. One and a half years later enlarged mediastinal lymph nodes were noted. Additional staging showed no other abnormalities and a media-stinoscopy was performed. The initial histologic examination confirmed the clinically suspected diagnosis of sarcoidosis. However, additional immunohistochemical analysis unexpectedly demonstrated that there was also a microscopic relapse of the testis tumor. The literature concerning the co-incidence of non-caseating granulomas and testis tumors is reviewed. It is not clear, whether the granulomas indicate the presence of genuine idiopathic sarcoidosis or whether they reflect a sarcoid-like reaction against tumor antigens. The immunopathogenesis of sarcoid formation and its possible biologic significance in obtaining a spontaneous tumor remission is discussed.</description><subject>Adult</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Diagnosis, Differential</subject><subject>Disease-Free Survival</subject><subject>germ cell tumors</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Mediastinal Diseases - pathology</subject><subject>Mediastinoscopy</subject><subject>Medical sciences</subject><subject>Orchiectomy</subject><subject>sarcoidosis</subject><subject>Sarcoidosis - complications</subject><subject>Sarcoidosis - pathology</subject><subject>Sarcoidosis - therapy</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Seminoma - complications</subject><subject>Seminoma - secondary</subject><subject>Seminoma - therapy</subject><subject>Testicular Neoplasms - complications</subject><subject>Testicular Neoplasms - pathology</subject><subject>Testicular Neoplasms - therapy</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM9LwzAYhoMoc07PnoQexFtd8qVNk12kDt2EoZf5Ay8hTVKsrs1MOnD_vZWVgafv8D7vy8eD0DnB1wQDHecTgjEHwBgDSfgBGpKUiZjjhByiIRZA4yylyTE6CeGzg5gAMUADwTAAy4aIT13V6MrYRtvIlVGwddW4WkWqMVFQXrvKuFCFSZRH9bb9iJyPSqXbm1N0VKpVsGf9HaHn-7vldB4vnmYP03wR6yRhbfeITjEnVmMDTCuVCc0LRUsOxoLhuCCpNYAzsIryjKqEaIZNSQtghAiR0hG62u2uvfve2NDKugrarlaqsW4TZCa4IAkjHTjegdq7ELwt5dpXtfJbSbD8cyVz-c9V17jopzdFbc2e7-V0-WWfq6DVqvSqMxX2GABkFP6weIdVobU_-1j5L9mNZKmcv73LxXL2Ao-vt1LQX79hfc0</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>Tjan-Heijnen, V. 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M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-80c5081ec0d26caa79c8ba3f82de2d80b15ed2072ea3873a41c60df3b26119953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Diagnosis, Differential</topic><topic>Disease-Free Survival</topic><topic>germ cell tumors</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Mediastinal Diseases - pathology</topic><topic>Mediastinoscopy</topic><topic>Medical sciences</topic><topic>Orchiectomy</topic><topic>sarcoidosis</topic><topic>Sarcoidosis - complications</topic><topic>Sarcoidosis - pathology</topic><topic>Sarcoidosis - therapy</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Seminoma - complications</topic><topic>Seminoma - secondary</topic><topic>Seminoma - therapy</topic><topic>Testicular Neoplasms - complications</topic><topic>Testicular Neoplasms - pathology</topic><topic>Testicular Neoplasms - therapy</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tjan-Heijnen, V. C. G.</creatorcontrib><creatorcontrib>Vlasveld, L. Th</creatorcontrib><creatorcontrib>Pernet, F. P. P. M.</creatorcontrib><creatorcontrib>Pauwels, P.</creatorcontrib><creatorcontrib>De Mulder, P. H. 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M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coincidence of seminoma and sarcoidosis: A myth or fact?</atitle><jtitle>Annals of oncology</jtitle><addtitle>Ann Oncol</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>9</volume><issue>3</issue><spage>321</spage><epage>325</epage><pages>321-325</pages><issn>0923-7534</issn><eissn>1569-8041</eissn><abstract>A patient with a stage II seminoma of the testis was treated with a routine orchidectomy and irradiation. One and a half years later enlarged mediastinal lymph nodes were noted. Additional staging showed no other abnormalities and a media-stinoscopy was performed. The initial histologic examination confirmed the clinically suspected diagnosis of sarcoidosis. However, additional immunohistochemical analysis unexpectedly demonstrated that there was also a microscopic relapse of the testis tumor. The literature concerning the co-incidence of non-caseating granulomas and testis tumors is reviewed. It is not clear, whether the granulomas indicate the presence of genuine idiopathic sarcoidosis or whether they reflect a sarcoid-like reaction against tumor antigens. The immunopathogenesis of sarcoid formation and its possible biologic significance in obtaining a spontaneous tumor remission is discussed.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>9602267</pmid><doi>10.1023/A:1008220002148</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Antineoplastic Agents - therapeutic use Biological and medical sciences Diagnosis, Differential Disease-Free Survival germ cell tumors Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Lymphatic Metastasis Male Male genital diseases Mediastinal Diseases - pathology Mediastinoscopy Medical sciences Orchiectomy sarcoidosis Sarcoidosis - complications Sarcoidosis - pathology Sarcoidosis - therapy Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Seminoma - complications Seminoma - secondary Seminoma - therapy Testicular Neoplasms - complications Testicular Neoplasms - pathology Testicular Neoplasms - therapy Tomography, X-Ray Computed Tumors |
| title | Coincidence of seminoma and sarcoidosis: A myth or fact? |
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