Metabolism of the diuretic bumetanide in healthy subjects and patients with renal impairment
The pharmacokinetics and metabolism of orally administered bumetanide were studied in five healthy subjects and in five patients with renal insufficiency. Healthy subjects excreted 51% of the dose as unchanged drug in the urine, whilst the patients with renal insufficiency excreted only 11% of the d...
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| Veröffentlicht in: | European journal of clinical pharmacology 1990-01, Vol.38 (6), p.583-586 |
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| container_title | European journal of clinical pharmacology |
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| creator | HOWLETT, M. R SKELLERN, G. G AULD, W. H. R MURDOCH, W. R |
| description | The pharmacokinetics and metabolism of orally administered bumetanide were studied in five healthy subjects and in five patients with renal insufficiency. Healthy subjects excreted 51% of the dose as unchanged drug in the urine, whilst the patients with renal insufficiency excreted only 11% of the dose as bumetanide. Similarly the urinary excretion of the gamma-hydroxybutyl metabolite was reduced from 6% in healthy subjects to 2.3% in patients with renal impairment. In both groups of subjects the mean elimination half-life of the metabolite was greater than for bumetanide. The results indicate a possible accumulation of bumetanide and metabolite in patient with renal failure. |
| doi_str_mv | 10.1007/BF00278586 |
| format | Article |
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R ; SKELLERN, G. G ; AULD, W. H. R ; MURDOCH, W. R</creator><creatorcontrib>HOWLETT, M. R ; SKELLERN, G. G ; AULD, W. H. R ; MURDOCH, W. R</creatorcontrib><description>The pharmacokinetics and metabolism of orally administered bumetanide were studied in five healthy subjects and in five patients with renal insufficiency. Healthy subjects excreted 51% of the dose as unchanged drug in the urine, whilst the patients with renal insufficiency excreted only 11% of the dose as bumetanide. Similarly the urinary excretion of the gamma-hydroxybutyl metabolite was reduced from 6% in healthy subjects to 2.3% in patients with renal impairment. In both groups of subjects the mean elimination half-life of the metabolite was greater than for bumetanide. The results indicate a possible accumulation of bumetanide and metabolite in patient with renal failure.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00278586</identifier><identifier>PMID: 2373133</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Aged ; Biological and medical sciences ; Bumetanide - metabolism ; Bumetanide - pharmacokinetics ; Bumetanide - urine ; Diuretics - metabolism ; Female ; Furosemide - metabolism ; Furosemide - pharmacokinetics ; Furosemide - urine ; Half-Life ; Humans ; Kidney Diseases - metabolism ; Kidney Diseases - urine ; Male ; Medical sciences ; Middle Aged ; Pharmacology. 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R</creatorcontrib><creatorcontrib>MURDOCH, W. R</creatorcontrib><title>Metabolism of the diuretic bumetanide in healthy subjects and patients with renal impairment</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>The pharmacokinetics and metabolism of orally administered bumetanide were studied in five healthy subjects and in five patients with renal insufficiency. Healthy subjects excreted 51% of the dose as unchanged drug in the urine, whilst the patients with renal insufficiency excreted only 11% of the dose as bumetanide. Similarly the urinary excretion of the gamma-hydroxybutyl metabolite was reduced from 6% in healthy subjects to 2.3% in patients with renal impairment. In both groups of subjects the mean elimination half-life of the metabolite was greater than for bumetanide. The results indicate a possible accumulation of bumetanide and metabolite in patient with renal failure.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Bumetanide - metabolism</subject><subject>Bumetanide - pharmacokinetics</subject><subject>Bumetanide - urine</subject><subject>Diuretics - metabolism</subject><subject>Female</subject><subject>Furosemide - metabolism</subject><subject>Furosemide - pharmacokinetics</subject><subject>Furosemide - urine</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Kidney Diseases - metabolism</subject><subject>Kidney Diseases - urine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Urinary system</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LAzEUxIMotVYv3oUcxIOw-rJJN5ujFqtCxYvehCXJvqUp-1GTLNL_3pUu9fSYNz9mYAi5ZHDHAOT94xIglfk8z47IlAmeJgwEOyZTAM6STEk4JWchbADYXAGfkEnKJWecT8nXG0ZtutqFhnYVjWukpes9Rmep6ZvBbF2J1LV0jbqO6x0NvdmgjYHqtqRbHR22g_hxcU09trqmrtlq55vhfU5OKl0HvBjvjHwunz4WL8nq_fl18bBKbCohJqXMjGTCCkxZxrO5kkKrkvNKMtBGVKkxTCtRDZpJyxRaYQTmskKeg8iAz8jNPnfru-8eQywaFyzWtW6x60MhVa5ApHwAb_eg9V0IHqti612j_a5gUPxNWfxPOcBXY2pvGiwP6Ljd4F-Pvg5W15XXrXXhgGWKqaGX_wJjPXr1</recordid><startdate>19900101</startdate><enddate>19900101</enddate><creator>HOWLETT, M. R</creator><creator>SKELLERN, G. G</creator><creator>AULD, W. H. R</creator><creator>MURDOCH, W. 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Drug treatments</topic><topic>Urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOWLETT, M. R</creatorcontrib><creatorcontrib>SKELLERN, G. G</creatorcontrib><creatorcontrib>AULD, W. H. R</creatorcontrib><creatorcontrib>MURDOCH, W. R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HOWLETT, M. R</au><au>SKELLERN, G. G</au><au>AULD, W. H. R</au><au>MURDOCH, W. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolism of the diuretic bumetanide in healthy subjects and patients with renal impairment</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1990-01-01</date><risdate>1990</risdate><volume>38</volume><issue>6</issue><spage>583</spage><epage>586</epage><pages>583-586</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>The pharmacokinetics and metabolism of orally administered bumetanide were studied in five healthy subjects and in five patients with renal insufficiency. Healthy subjects excreted 51% of the dose as unchanged drug in the urine, whilst the patients with renal insufficiency excreted only 11% of the dose as bumetanide. Similarly the urinary excretion of the gamma-hydroxybutyl metabolite was reduced from 6% in healthy subjects to 2.3% in patients with renal impairment. In both groups of subjects the mean elimination half-life of the metabolite was greater than for bumetanide. The results indicate a possible accumulation of bumetanide and metabolite in patient with renal failure.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>2373133</pmid><doi>10.1007/BF00278586</doi><tpages>4</tpages></addata></record> |
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| ispartof | European journal of clinical pharmacology, 1990-01, Vol.38 (6), p.583-586 |
| issn | 0031-6970 1432-1041 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Biological and medical sciences Bumetanide - metabolism Bumetanide - pharmacokinetics Bumetanide - urine Diuretics - metabolism Female Furosemide - metabolism Furosemide - pharmacokinetics Furosemide - urine Half-Life Humans Kidney Diseases - metabolism Kidney Diseases - urine Male Medical sciences Middle Aged Pharmacology. Drug treatments Urinary system |
| title | Metabolism of the diuretic bumetanide in healthy subjects and patients with renal impairment |
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