DNA Interactions of a Novel Platinum Drug, cis-[PtCl(NH3)2(N7-Acyclovir)]

We synthesized a novel platinum drug,cis-[PtCl(NH3)2(N7-ACV)]+, in which ACV is the antiviral drug acyclovir [a deoxyriboguanosine analogue, 9-(2-hydroxyethoxymethyl)guanine]. This new compound exhibits antiviral efficacy in vitro and exhibits an antitumor activity profile different from that of cis...

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Veröffentlicht in:	Molecular pharmacology 1998-05, Vol.53 (5), p.846-855
Hauptverfasser:	Balcarová, Zdenka, Kaspárková, Jana, Zákovská, Alena, Nováková, Olga, Sivo, Maria F., Natile, Giovanni, Brabec, Viktor
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - analogs & derivatives Acyclovir - pharmacology Animals Antineoplastic Agents - pharmacology Base Sequence Cattle DNA - drug effects Molecular Sequence Data Organoplatinum Compounds - pharmacology Spectrometry, Fluorescence
Online-Zugang:	Volltext
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