Divergent Effects of Angiotensin-Converting Enzyme Inhibition and Angiotensin II-Receptor Antagonism on Myocardial Cellular Proliferation and Collagen Deposition After Myocardial Infarction in Rats

There is mechanistic rationale to suggest differential effects of angiotensin-converting enzyme (ACE) inhibition and angiotensin II type 1 (AT1)-receptor antagonism on ventricular remodeling after myocardial infarction (MI). We compared the effects of ACE inhibition, AT1-receptor antagonism, and the...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1998-05, Vol.31 (5), p.654-660
Hauptverfasser:	Taylor, Kenneth, Patten, Richard D, Smith, John J, Aronovitz, Mark J, Wight, Joseph, Salomon, Robert N, Konstam, Marvin A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Antianginal agents. Coronary vasodilator agents Antihypertensive Agents - pharmacology Biological and medical sciences Cardiovascular system Cell Division - drug effects Collagen - drug effects Collagen - metabolism Enalapril - pharmacology Losartan - pharmacology Male Medical sciences Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardium - cytology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley
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