Passive Immunization of Newborn Rhesus Macaques Prevents Oral Simian Immunodeficiency Virus Infection
To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression...
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| Veröffentlicht in: | The Journal of infectious diseases 1998-05, Vol.177 (5), p.1247-1259 |
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| container_title | The Journal of infectious diseases |
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| creator | Van Rompay, Koen K. A. Berardi, Christopher J. Dillard-Telm, Stephan Tarara, Ross P. Canfield, Don R. Valverde, Celia R. Montefiori, David C. Cole, Kelly Stefano Montelaro, Ronald C. Miller, Christopher J. Marthas, Marta L. |
| description | To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression in newborn rhesus macaques was tested. Untreated neonates became infected after oral SIV inoculation and had high viremia, and most animals developed fatal AIDS within 3 months. In contrast, SIV hyperimmune serum given subcutaneously prior to oral SIV inoculation protected 6 newborns against infection. When this SIV hyperimmune serum was given to 3 newborns 3 weeks after oral SIV inoculation, viremia was not reduced, and all 3 infants died within 3 months of age due to AIDS and immune-complex disease. These results suggest that passively acquired antihuman immunodeficiency virus (HIV) IgG may decrease perinatal HIV transmission. However, anti-HIV IgG may not impart therapeutic benefit to infants with established HIV infection. |
| doi_str_mv | 10.1086/515270 |
| format | Article |
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A. ; Berardi, Christopher J. ; Dillard-Telm, Stephan ; Tarara, Ross P. ; Canfield, Don R. ; Valverde, Celia R. ; Montefiori, David C. ; Cole, Kelly Stefano ; Montelaro, Ronald C. ; Miller, Christopher J. ; Marthas, Marta L.</creator><creatorcontrib>Van Rompay, Koen K. A. ; Berardi, Christopher J. ; Dillard-Telm, Stephan ; Tarara, Ross P. ; Canfield, Don R. ; Valverde, Celia R. ; Montefiori, David C. ; Cole, Kelly Stefano ; Montelaro, Ronald C. ; Miller, Christopher J. ; Marthas, Marta L.</creatorcontrib><description>To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression in newborn rhesus macaques was tested. Untreated neonates became infected after oral SIV inoculation and had high viremia, and most animals developed fatal AIDS within 3 months. In contrast, SIV hyperimmune serum given subcutaneously prior to oral SIV inoculation protected 6 newborns against infection. When this SIV hyperimmune serum was given to 3 newborns 3 weeks after oral SIV inoculation, viremia was not reduced, and all 3 infants died within 3 months of age due to AIDS and immune-complex disease. These results suggest that passively acquired antihuman immunodeficiency virus (HIV) IgG may decrease perinatal HIV transmission. However, anti-HIV IgG may not impart therapeutic benefit to infants with established HIV infection.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/515270</identifier><identifier>PMID: 9593009</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Acquired Immunodeficiency Syndrome - immunology ; Acquired Immunodeficiency Syndrome - prevention & control ; Administration, Oral ; AIDS ; AIDS/HIV ; Animals ; Animals, Newborn ; Antibodies ; Antibodies, Viral - blood ; Antibody Formation ; Biological and medical sciences ; Blood plasma ; Child ; Enzyme-Linked Immunosorbent Assay ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunization, Passive ; Immunoglobulin A - blood ; Immunoglobulin G - blood ; Infants ; Infections ; Inoculation ; Kidney - immunology ; Kidney - pathology ; Macaca mulatta ; Major Articles ; Microbiology ; Newborns ; Passive immunization ; Physiological immunosuppression ; Simian Acquired Immunodeficiency Syndrome - immunology ; Simian Acquired Immunodeficiency Syndrome - prevention & control ; Simian Acquired Immunodeficiency Syndrome - transmission ; Simian Immunodeficiency Virus ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Viremia - immunology ; Viremia - prevention & control ; Virology ; Viruses</subject><ispartof>The Journal of infectious diseases, 1998-05, Vol.177 (5), p.1247-1259</ispartof><rights>Copyright 1998 University of Chicago</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-3f12da6d6bc3af459e70b9c6ab4319bab216786ef5e3e42ff630873e11610b933</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30108144$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30108144$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2247785$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9593009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Rompay, Koen K. A.</creatorcontrib><creatorcontrib>Berardi, Christopher J.</creatorcontrib><creatorcontrib>Dillard-Telm, Stephan</creatorcontrib><creatorcontrib>Tarara, Ross P.</creatorcontrib><creatorcontrib>Canfield, Don R.</creatorcontrib><creatorcontrib>Valverde, Celia R.</creatorcontrib><creatorcontrib>Montefiori, David C.</creatorcontrib><creatorcontrib>Cole, Kelly Stefano</creatorcontrib><creatorcontrib>Montelaro, Ronald C.</creatorcontrib><creatorcontrib>Miller, Christopher J.</creatorcontrib><creatorcontrib>Marthas, Marta L.</creatorcontrib><title>Passive Immunization of Newborn Rhesus Macaques Prevents Oral Simian Immunodeficiency Virus Infection</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression in newborn rhesus macaques was tested. Untreated neonates became infected after oral SIV inoculation and had high viremia, and most animals developed fatal AIDS within 3 months. In contrast, SIV hyperimmune serum given subcutaneously prior to oral SIV inoculation protected 6 newborns against infection. When this SIV hyperimmune serum was given to 3 newborns 3 weeks after oral SIV inoculation, viremia was not reduced, and all 3 infants died within 3 months of age due to AIDS and immune-complex disease. These results suggest that passively acquired antihuman immunodeficiency virus (HIV) IgG may decrease perinatal HIV transmission. However, anti-HIV IgG may not impart therapeutic benefit to infants with established HIV infection.</description><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>Acquired Immunodeficiency Syndrome - prevention & control</subject><subject>Administration, Oral</subject><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Antibody Formation</subject><subject>Biological and medical sciences</subject><subject>Blood plasma</subject><subject>Child</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fundamental and applied biological sciences. 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A.</creator><creator>Berardi, Christopher J.</creator><creator>Dillard-Telm, Stephan</creator><creator>Tarara, Ross P.</creator><creator>Canfield, Don R.</creator><creator>Valverde, Celia R.</creator><creator>Montefiori, David C.</creator><creator>Cole, Kelly Stefano</creator><creator>Montelaro, Ronald C.</creator><creator>Miller, Christopher J.</creator><creator>Marthas, Marta L.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980501</creationdate><title>Passive Immunization of Newborn Rhesus Macaques Prevents Oral Simian Immunodeficiency Virus Infection</title><author>Van Rompay, Koen K. A. ; Berardi, Christopher J. ; Dillard-Telm, Stephan ; Tarara, Ross P. ; Canfield, Don R. ; Valverde, Celia R. ; Montefiori, David C. ; Cole, Kelly Stefano ; Montelaro, Ronald C. ; Miller, Christopher J. ; Marthas, Marta L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-3f12da6d6bc3af459e70b9c6ab4319bab216786ef5e3e42ff630873e11610b933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acquired Immunodeficiency Syndrome - immunology</topic><topic>Acquired Immunodeficiency Syndrome - prevention & control</topic><topic>Administration, Oral</topic><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antibodies</topic><topic>Antibodies, Viral - blood</topic><topic>Antibody Formation</topic><topic>Biological and medical sciences</topic><topic>Blood plasma</topic><topic>Child</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunization, Passive</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin G - blood</topic><topic>Infants</topic><topic>Infections</topic><topic>Inoculation</topic><topic>Kidney - immunology</topic><topic>Kidney - pathology</topic><topic>Macaca mulatta</topic><topic>Major Articles</topic><topic>Microbiology</topic><topic>Newborns</topic><topic>Passive immunization</topic><topic>Physiological immunosuppression</topic><topic>Simian Acquired Immunodeficiency Syndrome - immunology</topic><topic>Simian Acquired Immunodeficiency Syndrome - prevention & control</topic><topic>Simian Acquired Immunodeficiency Syndrome - transmission</topic><topic>Simian Immunodeficiency Virus</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Viremia - immunology</topic><topic>Viremia - prevention & control</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Rompay, Koen K. 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A.</au><au>Berardi, Christopher J.</au><au>Dillard-Telm, Stephan</au><au>Tarara, Ross P.</au><au>Canfield, Don R.</au><au>Valverde, Celia R.</au><au>Montefiori, David C.</au><au>Cole, Kelly Stefano</au><au>Montelaro, Ronald C.</au><au>Miller, Christopher J.</au><au>Marthas, Marta L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Passive Immunization of Newborn Rhesus Macaques Prevents Oral Simian Immunodeficiency Virus Infection</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>177</volume><issue>5</issue><spage>1247</spage><epage>1259</epage><pages>1247-1259</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression in newborn rhesus macaques was tested. Untreated neonates became infected after oral SIV inoculation and had high viremia, and most animals developed fatal AIDS within 3 months. In contrast, SIV hyperimmune serum given subcutaneously prior to oral SIV inoculation protected 6 newborns against infection. When this SIV hyperimmune serum was given to 3 newborns 3 weeks after oral SIV inoculation, viremia was not reduced, and all 3 infants died within 3 months of age due to AIDS and immune-complex disease. These results suggest that passively acquired antihuman immunodeficiency virus (HIV) IgG may decrease perinatal HIV transmission. However, anti-HIV IgG may not impart therapeutic benefit to infants with established HIV infection.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>9593009</pmid><doi>10.1086/515270</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 1998-05, Vol.177 (5), p.1247-1259 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - prevention & control Administration, Oral AIDS AIDS/HIV Animals Animals, Newborn Antibodies Antibodies, Viral - blood Antibody Formation Biological and medical sciences Blood plasma Child Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Humans Immunization, Passive Immunoglobulin A - blood Immunoglobulin G - blood Infants Infections Inoculation Kidney - immunology Kidney - pathology Macaca mulatta Major Articles Microbiology Newborns Passive immunization Physiological immunosuppression Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian Acquired Immunodeficiency Syndrome - transmission Simian Immunodeficiency Virus Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viremia - immunology Viremia - prevention & control Virology Viruses |
| title | Passive Immunization of Newborn Rhesus Macaques Prevents Oral Simian Immunodeficiency Virus Infection |
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