Thrombospondin-1 and its CSVTCG-specific receptor in wound healing and cancer
Growth factors play a crucial role in the regulation of cellular proliferation and matrix degradation in wound healing and cancer. We have shown that thrombospondin 1 (TSP-1) and its cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG)-specific receptor play a key role in cell invasion and mat...
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| Veröffentlicht in: | Annals of plastic surgery 1998-05, Vol.40 (5), p.494-501 |
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| container_title | Annals of plastic surgery |
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| creator | ROTH, J. J ALBO, D ROTHMAN, V. L LONGAKER, M. T GRANICK, M. S LONG, C. D SOLOMON, M. P TUSZYNSKI, G. P |
| description | Growth factors play a crucial role in the regulation of cellular proliferation and matrix degradation in wound healing and cancer. We have shown that thrombospondin 1 (TSP-1) and its cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG)-specific receptor play a key role in cell invasion and matrix degradation in different carcinomas. The present study was done to determine whether TSP-1 and its receptor show a similar pattern of expression in wound healing and cancer. Expression and localization of TSP-1 and its receptor were determined in fetal wounds, adult burn wounds, and different human malignancies by immunohistochemical staining and computerized image analysis. In healing wounds, TSP-1 was expressed in the stroma early in the process, followed by a steep decline. The TSP-1 receptor localized to neovessels and highly proliferating cells (i.e., fibroblasts, basal cells), its levels remaining relatively constant. Cancer cells and tumor-associated microvessels expressed the TSP-1 receptor, whereas TSP-1 localized predominantly to the tumor-associated stroma. These data suggest a critical role for TSP-1 and its CSVTCG-specific receptor in wound healing and cancer. |
| doi_str_mv | 10.1097/00000637-199805000-00009 |
| format | Article |
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J ; ALBO, D ; ROTHMAN, V. L ; LONGAKER, M. T ; GRANICK, M. S ; LONG, C. D ; SOLOMON, M. P ; TUSZYNSKI, G. P</creator><creatorcontrib>ROTH, J. J ; ALBO, D ; ROTHMAN, V. L ; LONGAKER, M. T ; GRANICK, M. S ; LONG, C. D ; SOLOMON, M. P ; TUSZYNSKI, G. P</creatorcontrib><description>Growth factors play a crucial role in the regulation of cellular proliferation and matrix degradation in wound healing and cancer. We have shown that thrombospondin 1 (TSP-1) and its cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG)-specific receptor play a key role in cell invasion and matrix degradation in different carcinomas. The present study was done to determine whether TSP-1 and its receptor show a similar pattern of expression in wound healing and cancer. Expression and localization of TSP-1 and its receptor were determined in fetal wounds, adult burn wounds, and different human malignancies by immunohistochemical staining and computerized image analysis. In healing wounds, TSP-1 was expressed in the stroma early in the process, followed by a steep decline. The TSP-1 receptor localized to neovessels and highly proliferating cells (i.e., fibroblasts, basal cells), its levels remaining relatively constant. Cancer cells and tumor-associated microvessels expressed the TSP-1 receptor, whereas TSP-1 localized predominantly to the tumor-associated stroma. 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Expression and localization of TSP-1 and its receptor were determined in fetal wounds, adult burn wounds, and different human malignancies by immunohistochemical staining and computerized image analysis. In healing wounds, TSP-1 was expressed in the stroma early in the process, followed by a steep decline. The TSP-1 receptor localized to neovessels and highly proliferating cells (i.e., fibroblasts, basal cells), its levels remaining relatively constant. Cancer cells and tumor-associated microvessels expressed the TSP-1 receptor, whereas TSP-1 localized predominantly to the tumor-associated stroma. These data suggest a critical role for TSP-1 and its CSVTCG-specific receptor in wound healing and cancer.</description><subject>Adult</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Dermatology</subject><subject>Epithelium - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thrombospondin-1 and its CSVTCG-specific receptor in wound healing and cancer</atitle><jtitle>Annals of plastic surgery</jtitle><addtitle>Ann Plast Surg</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>40</volume><issue>5</issue><spage>494</spage><epage>501</epage><pages>494-501</pages><issn>0148-7043</issn><eissn>1536-3708</eissn><coden>APCSD4</coden><abstract>Growth factors play a crucial role in the regulation of cellular proliferation and matrix degradation in wound healing and cancer. We have shown that thrombospondin 1 (TSP-1) and its cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG)-specific receptor play a key role in cell invasion and matrix degradation in different carcinomas. The present study was done to determine whether TSP-1 and its receptor show a similar pattern of expression in wound healing and cancer. Expression and localization of TSP-1 and its receptor were determined in fetal wounds, adult burn wounds, and different human malignancies by immunohistochemical staining and computerized image analysis. In healing wounds, TSP-1 was expressed in the stroma early in the process, followed by a steep decline. The TSP-1 receptor localized to neovessels and highly proliferating cells (i.e., fibroblasts, basal cells), its levels remaining relatively constant. Cancer cells and tumor-associated microvessels expressed the TSP-1 receptor, whereas TSP-1 localized predominantly to the tumor-associated stroma. These data suggest a critical role for TSP-1 and its CSVTCG-specific receptor in wound healing and cancer.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>9600434</pmid><doi>10.1097/00000637-199805000-00009</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0148-7043 |
| ispartof | Annals of plastic surgery, 1998-05, Vol.40 (5), p.494-501 |
| issn | 0148-7043 1536-3708 |
| language | eng |
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| subjects | Adult Animals Biological and medical sciences Breast Neoplasms - metabolism Breast Neoplasms - pathology Dermatology Epithelium - pathology Female Humans Image Processing, Computer-Assisted Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - metabolism Sheep Thrombospondin 1 - biosynthesis Thrombospondin 1 - metabolism Time Factors Wound Healing - physiology |
| title | Thrombospondin-1 and its CSVTCG-specific receptor in wound healing and cancer |
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