Chemotactic Factors in Bronchial Secretions of Cystic Fibrosis Patients
To understand chronic neutrophil attraction into cystic fibrosis airways, both global chemotactic activity and individual chemotactic factors were studied in bronchial secretions. Bronchial secretions of 8 cystic fibrosis patients, collected on the first day of admission for antibiotic treatment, sh...
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| Veröffentlicht in: | The Journal of infectious diseases 1998-05, Vol.177 (5), p.1413-1417 |
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| container_title | The Journal of infectious diseases |
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| creator | Pastore, Fabienne Dayer Schlegel-Haueter, Susanna E. Belli, Dominique C. Rochat, Thierry Dudez, Tecla S. Suter, Susanne |
| description | To understand chronic neutrophil attraction into cystic fibrosis airways, both global chemotactic activity and individual chemotactic factors were studied in bronchial secretions. Bronchial secretions of 8 cystic fibrosis patients, collected on the first day of admission for antibiotic treatment, showed a high chemotactic index (19.4 ± 5.7, n = 8). Fractionation by gel filtration of bronchial secretions resulted in three chemotactic fractions. The first factor corresponded to interleukin-8, and the second activated neutrophils via the FMLP receptor. The third factor, which was of lower molecular weight, did not activate FMLP or leukotriene B4 receptors, and its nature is still under investigation. Treating patients with antibiotics reduced global chemotactic activity, mainly by reducing the activity due to stimulation of the FMLP receptor. |
| doi_str_mv | 10.1086/517827 |
| format | Article |
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Bronchial secretions of 8 cystic fibrosis patients, collected on the first day of admission for antibiotic treatment, showed a high chemotactic index (19.4 ± 5.7, n = 8). Fractionation by gel filtration of bronchial secretions resulted in three chemotactic fractions. The first factor corresponded to interleukin-8, and the second activated neutrophils via the FMLP receptor. The third factor, which was of lower molecular weight, did not activate FMLP or leukotriene B4 receptors, and its nature is still under investigation. Treating patients with antibiotics reduced global chemotactic activity, mainly by reducing the activity due to stimulation of the FMLP receptor.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/517827</identifier><identifier>PMID: 9593037</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Aminoglycosides ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Bacterial diseases ; Bacterial diseases of the respiratory system ; Biological and medical sciences ; Bronchi - metabolism ; Bronchoalveolar Lavage Fluid - chemistry ; Cephalosporins - therapeutic use ; Chemotactic factors ; Chemotactic Factors - analysis ; Chemotaxis, Leukocyte ; Child ; Chromatography, Gel ; Concise Communications ; Cystic fibrosis ; Cystic Fibrosis - complications ; Cystic Fibrosis - physiopathology ; Drug Therapy, Combination - therapeutic use ; Elution ; Fractionation ; Human bacterial diseases ; Humans ; Infectious diseases ; Leukotrienes ; Medical sciences ; Middle Aged ; Neutrophils ; Pseudomonas Infections - complications ; Pseudomonas Infections - drug therapy ; Receptors ; Secretion ; Sputum ; Sputum - chemistry</subject><ispartof>The Journal of infectious diseases, 1998-05, Vol.177 (5), p.1413-1417</ispartof><rights>Copyright 1998 University of Chicago</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-80941038c480ebe437999702f32447166f18bb690f5fafd38a10edbf6ac859d23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30108172$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30108172$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27903,27904,57996,58229</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2250493$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9593037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pastore, Fabienne Dayer</creatorcontrib><creatorcontrib>Schlegel-Haueter, Susanna E.</creatorcontrib><creatorcontrib>Belli, Dominique C.</creatorcontrib><creatorcontrib>Rochat, Thierry</creatorcontrib><creatorcontrib>Dudez, Tecla S.</creatorcontrib><creatorcontrib>Suter, Susanne</creatorcontrib><title>Chemotactic Factors in Bronchial Secretions of Cystic Fibrosis Patients</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>To understand chronic neutrophil attraction into cystic fibrosis airways, both global chemotactic activity and individual chemotactic factors were studied in bronchial secretions. Bronchial secretions of 8 cystic fibrosis patients, collected on the first day of admission for antibiotic treatment, showed a high chemotactic index (19.4 ± 5.7, n = 8). Fractionation by gel filtration of bronchial secretions resulted in three chemotactic fractions. The first factor corresponded to interleukin-8, and the second activated neutrophils via the FMLP receptor. The third factor, which was of lower molecular weight, did not activate FMLP or leukotriene B4 receptors, and its nature is still under investigation. Treating patients with antibiotics reduced global chemotactic activity, mainly by reducing the activity due to stimulation of the FMLP receptor.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aminoglycosides</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the respiratory system</subject><subject>Biological and medical sciences</subject><subject>Bronchi - metabolism</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>Cephalosporins - therapeutic use</subject><subject>Chemotactic factors</subject><subject>Chemotactic Factors - analysis</subject><subject>Chemotaxis, Leukocyte</subject><subject>Child</subject><subject>Chromatography, Gel</subject><subject>Concise Communications</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - complications</subject><subject>Cystic Fibrosis - physiopathology</subject><subject>Drug Therapy, Combination - therapeutic use</subject><subject>Elution</subject><subject>Fractionation</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Leukotrienes</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neutrophils</subject><subject>Pseudomonas Infections - complications</subject><subject>Pseudomonas Infections - drug therapy</subject><subject>Receptors</subject><subject>Secretion</subject><subject>Sputum</subject><subject>Sputum - chemistry</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMoOt7eQOhC3FVPkjaXpRYdhcELKoibkGYSjHZazemAvr3VGcal2ZzF9_GfnJ-QfQrHFJQ4KalUTK6RES25zIWgfJ2MABjLqdJ6i2wjvgJAwYXcJJu61By4HJFx9eJnXW9dH112MYwuYRbb7Cx1rXuJtsnuvUu-j12LWRey6gt_zVinDiNmt7aPvu1xl2wE26DfW84d8nhx_lBd5pOb8VV1OsldwUSfK9AFBa5cocDXvuBSay2BBc6KQlIhAlV1LTSEMtgw5cpS8NM6COtUqaeM75CjRe576j7mHnszi-h809jWd3M0Uqvhwf8iFeWwnYo_0Q0XYfLBvKc4s-nLUDA_1ZpFtYN4sEyc1zM_XWnLLgd-uOQWnW1Csq2LuNIYK6HQ_C_mFYeyV5jDsIvKn4_nCx6x958rbtObEZLL0lw-PZvq-q665XxiKP8GziWWiw</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Pastore, Fabienne Dayer</creator><creator>Schlegel-Haueter, Susanna E.</creator><creator>Belli, Dominique C.</creator><creator>Rochat, Thierry</creator><creator>Dudez, Tecla S.</creator><creator>Suter, Susanne</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19980501</creationdate><title>Chemotactic Factors in Bronchial Secretions of Cystic Fibrosis Patients</title><author>Pastore, Fabienne Dayer ; 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Bronchial secretions of 8 cystic fibrosis patients, collected on the first day of admission for antibiotic treatment, showed a high chemotactic index (19.4 ± 5.7, n = 8). Fractionation by gel filtration of bronchial secretions resulted in three chemotactic fractions. The first factor corresponded to interleukin-8, and the second activated neutrophils via the FMLP receptor. The third factor, which was of lower molecular weight, did not activate FMLP or leukotriene B4 receptors, and its nature is still under investigation. Treating patients with antibiotics reduced global chemotactic activity, mainly by reducing the activity due to stimulation of the FMLP receptor.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>9593037</pmid><doi>10.1086/517827</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aminoglycosides Anti-Bacterial Agents - therapeutic use Antibiotics Bacterial diseases Bacterial diseases of the respiratory system Biological and medical sciences Bronchi - metabolism Bronchoalveolar Lavage Fluid - chemistry Cephalosporins - therapeutic use Chemotactic factors Chemotactic Factors - analysis Chemotaxis, Leukocyte Child Chromatography, Gel Concise Communications Cystic fibrosis Cystic Fibrosis - complications Cystic Fibrosis - physiopathology Drug Therapy, Combination - therapeutic use Elution Fractionation Human bacterial diseases Humans Infectious diseases Leukotrienes Medical sciences Middle Aged Neutrophils Pseudomonas Infections - complications Pseudomonas Infections - drug therapy Receptors Secretion Sputum Sputum - chemistry |
| title | Chemotactic Factors in Bronchial Secretions of Cystic Fibrosis Patients |
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