Expression and characterization of human CD4:immunoglobulin fusion proteins

Different chimeric antibody-like molecules consisting of the four human CD4 extracellular domains (amino acids 1-369) fused to different parts of human IgG1 and IgM heavy-chain constant regions have been created and expressed in mammalian cells. For both IgG1 and IgM fusion proteins, the best expres...

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Veröffentlicht in:	DNA and cell biology 1990-06, Vol.9 (5), p.347-353
Hauptverfasser:	Zettlmeissl, G, Gregersen, J P, Duport, J M, Mehdi, S, Reiner, G, Seed, B
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Animals Base Sequence CD4 Antigens - genetics CD4 Antigens - metabolism Cell Line Female Gene Products, env - metabolism Giant Cells - drug effects Half-Life HIV - drug effects HIV Envelope Protein gp160 Humans Immunoglobulin G - genetics Immunoglobulin G - metabolism Immunoglobulin M - genetics Immunoglobulin M - metabolism Macaca fascicularis Male Mice Molecular Sequence Data Protein Precursors - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Transfection
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