Coronary Vasorelaxant Effect of Levosimendan, a New Inodilator with Calcium-Sensitizing Properties

We examined the action of levosimendan, a new Ca-sensitizing inodilator, on isolated porcine coronary arteries. Vessel rings were studied in isometric myographs. Arterial cyclic adenosine monophosphate (cAMP) levels were determined by radioimmunoassay. Levosimendan (10−10 M) completely relaxed arter...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1998-05, Vol.31 (5), p.741-749
Hauptverfasser:	Gruhn, Nicolai, Nielsen-Kudsk, Jens Erik, Theilgaard, Sune, Bang, Lone, Olesen, Søren-Peter, Aldershvile, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium Channels - drug effects Calcium Channels - physiology Cardiotonic agents Cardiovascular system Coronary Vessels - drug effects Coronary Vessels - physiology Cyclic AMP - metabolism Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Guanylate Cyclase - drug effects Guanylate Cyclase - metabolism Hydrazones - pharmacology Medical sciences Pharmacology. Drug treatments Potassium Channels - drug effects Potassium Channels - physiology Prostaglandins - metabolism Pyridazines - pharmacology Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - metabolism Simendan Swine Vasodilation - drug effects Vasodilator Agents - pharmacology
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