Activation of Cancer Cell Proteases and Cytotoxicity by EGF and PDGF Growth Factors

The biological effects of EGF and PDGF growth factors on A172 and hEGFr-3T3 cell lines were studied using RBC induced cytolysis and polyacrylamide-gelatin gel electrophoresis assays. The authors report that growth factor-induced cytotoxicity in these cells is mediated by proteolytic enzymes. Treatme...

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Veröffentlicht in:	The American journal of the medical sciences 1990-07, Vol.300 (1), p.9-15
Hauptverfasser:	Di Stefano, John F., Kirchner, Michele, Dagenhardt, Kurt, Hagag, Nabil
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiloride - pharmacology Animals Biological and medical sciences Cancer Cell Line Cell Survival - drug effects Cells, Cultured Cycloheximide - pharmacology Enzyme Activation Epidermal Growth Factor - pharmacology Growth Factor Hemolysis - drug effects Humans Leupeptins - pharmacology Medical sciences Mice Peptide Hydrolases - metabolism Platelet-Derived Growth Factor - pharmacology Proteases Tosyllysine Chloromethyl Ketone - pharmacology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - enzymology Tumors
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