The association between telomerase, p53, and clinical staging in colorectal cancer
A proposed etiology of tumor activation involves p53 mutations while telomerase may serve as a key enzyme for maintenance of tumor cell proliferation. Telomerase activity levels were measured in colorectal adenocarcinomas and corresponding normal tissue using a modified telomeric repeat amplificatio...
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| Veröffentlicht in: | The American journal of surgery 1998-05, Vol.175 (5), p.364-366 |
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| container_title | The American journal of surgery |
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| creator | Brown, Tommy Aldous, Wade Lance, Raymond Blaser, Jason Baker, Thomas Williard, William Washington, Ft. Lewis |
| description | A proposed etiology of tumor activation involves p53 mutations while telomerase may serve as a key enzyme for maintenance of tumor cell proliferation.
Telomerase activity levels were measured in colorectal adenocarcinomas and corresponding normal tissue using a modified telomeric repeat amplification protocol, and p53 mutations were identified using irnmunohistochemical staining. Results were compared with staging data using regression analysis.
Telomerase activity was present in 23 of 23 (100%) of the tumors and only 2 (9%) of normal specimens (
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| doi_str_mv | 10.1016/S0002-9610(98)00057-9 |
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Telomerase activity levels were measured in colorectal adenocarcinomas and corresponding normal tissue using a modified telomeric repeat amplification protocol, and p53 mutations were identified using irnmunohistochemical staining. Results were compared with staging data using regression analysis.
Telomerase activity was present in 23 of 23 (100%) of the tumors and only 2 (9%) of normal specimens (
P <0.0001). The p53 mutations were present in 18 of 23 (78%) of the tumors. No significant correlation between p53 mutations, telomerase activity levels, and staging was found.
Telomerase activity in 100% of the tumors suggests telomerase activation is a universal event in colorectal tumor progression; however, telomerase activity appears to be independent of p53 mutations and clinical staging.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/S0002-9610(98)00057-9</identifier><identifier>PMID: 9600278</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - genetics ; Adenocarcinoma - pathology ; Aged ; Base Sequence ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - genetics ; Cell proliferation ; Clinical Enzyme Tests - methods ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunohistochemistry ; Male ; Medical sciences ; Molecular Sequence Data ; Mutation ; Neoplasm Staging ; p53 Protein ; Prospective Studies ; Regression Analysis ; Repetitive Sequences, Nucleic Acid ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Telomerase ; Telomerase - analysis ; Telomerase - genetics ; Tumor Suppressor Protein p53 - analysis ; Tumor Suppressor Protein p53 - genetics ; Tumors</subject><ispartof>The American journal of surgery, 1998-05, Vol.175 (5), p.364-366</ispartof><rights>1998 by Excerpta Medica, Inc. All rights reserved.</rights><rights>1998 INIST-CNRS</rights><rights>1998. by Excerpta Medica, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-1772e5c805e4faf12fc9f9b4fd9fabb16e4a9cb88a3b89691cf08c01c97f30293</citedby><cites>FETCH-LOGICAL-c417t-1772e5c805e4faf12fc9f9b4fd9fabb16e4a9cb88a3b89691cf08c01c97f30293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2847458081?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2263222$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9600278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, Tommy</creatorcontrib><creatorcontrib>Aldous, Wade</creatorcontrib><creatorcontrib>Lance, Raymond</creatorcontrib><creatorcontrib>Blaser, Jason</creatorcontrib><creatorcontrib>Baker, Thomas</creatorcontrib><creatorcontrib>Williard, William</creatorcontrib><creatorcontrib>Washington, Ft. Lewis</creatorcontrib><title>The association between telomerase, p53, and clinical staging in colorectal cancer</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>A proposed etiology of tumor activation involves p53 mutations while telomerase may serve as a key enzyme for maintenance of tumor cell proliferation.
Telomerase activity levels were measured in colorectal adenocarcinomas and corresponding normal tissue using a modified telomeric repeat amplification protocol, and p53 mutations were identified using irnmunohistochemical staining. Results were compared with staging data using regression analysis.
Telomerase activity was present in 23 of 23 (100%) of the tumors and only 2 (9%) of normal specimens (
P <0.0001). The p53 mutations were present in 18 of 23 (78%) of the tumors. No significant correlation between p53 mutations, telomerase activity levels, and staging was found.
Telomerase activity in 100% of the tumors suggests telomerase activation is a universal event in colorectal tumor progression; however, telomerase activity appears to be independent of p53 mutations and clinical staging.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Cell proliferation</subject><subject>Clinical Enzyme Tests - methods</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Neoplasm Staging</subject><subject>p53 Protein</subject><subject>Prospective Studies</subject><subject>Regression Analysis</subject><subject>Repetitive Sequences, Nucleic Acid</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Telomerase</subject><subject>Telomerase - analysis</subject><subject>Telomerase - genetics</subject><subject>Tumor Suppressor Protein p53 - analysis</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Tumors</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkF1rFDEUhkNR2nXtTygElKLQqUkmM0muSil-QUGo9Tpkzpy0KbPJmswq_nuz3WUvvPEqnLzPObw8hJxxdskZ7z98Z4yJxvScvTP6fR061ZgjsuBamYZr3b4giwNyQl6V8lRHzmV7TI5NXxOlF-Tu_hGpKyVBcHNIkQ44_0aMdMYprTC7ghd03bUX1MWRwhRiADfRMruHEB9oiBTSlDLCXH_BRcD8mrz0bip4un-X5Menj_c3X5rbb5-_3lzfNiC5mhuulMAONOtQeue58GC8GaQfjXfDwHuUzsCgtWsHbXrDwTMNjINRvmXCtEtyvru7zunnBstsV6EATpOLmDbFKqO1lFXEkrz5B3xKmxxrNyu0VLLTTPNKdTsKciolo7frHFYu_7Gc2a1x-2zcbnVao-2zcbutcba_vhlWOB629opr_nafu1LV-VwlhXLAhOhbIUTFrnYYVmW_AmZbIGD1OYatXTum8J8ifwFhMJvv</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Brown, Tommy</creator><creator>Aldous, Wade</creator><creator>Lance, Raymond</creator><creator>Blaser, Jason</creator><creator>Baker, Thomas</creator><creator>Williard, William</creator><creator>Washington, Ft. 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Lewis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-1772e5c805e4faf12fc9f9b4fd9fabb16e4a9cb88a3b89691cf08c01c97f30293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Cell proliferation</topic><topic>Clinical Enzyme Tests - methods</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Neoplasm Staging</topic><topic>p53 Protein</topic><topic>Prospective Studies</topic><topic>Regression Analysis</topic><topic>Repetitive Sequences, Nucleic Acid</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Telomerase</topic><topic>Telomerase - analysis</topic><topic>Telomerase - genetics</topic><topic>Tumor Suppressor Protein p53 - analysis</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brown, Tommy</creatorcontrib><creatorcontrib>Aldous, Wade</creatorcontrib><creatorcontrib>Lance, Raymond</creatorcontrib><creatorcontrib>Blaser, Jason</creatorcontrib><creatorcontrib>Baker, Thomas</creatorcontrib><creatorcontrib>Williard, William</creatorcontrib><creatorcontrib>Washington, Ft. 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Lewis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between telomerase, p53, and clinical staging in colorectal cancer</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>175</volume><issue>5</issue><spage>364</spage><epage>366</epage><pages>364-366</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>A proposed etiology of tumor activation involves p53 mutations while telomerase may serve as a key enzyme for maintenance of tumor cell proliferation.
Telomerase activity levels were measured in colorectal adenocarcinomas and corresponding normal tissue using a modified telomeric repeat amplification protocol, and p53 mutations were identified using irnmunohistochemical staining. Results were compared with staging data using regression analysis.
Telomerase activity was present in 23 of 23 (100%) of the tumors and only 2 (9%) of normal specimens (
P <0.0001). The p53 mutations were present in 18 of 23 (78%) of the tumors. No significant correlation between p53 mutations, telomerase activity levels, and staging was found.
Telomerase activity in 100% of the tumors suggests telomerase activation is a universal event in colorectal tumor progression; however, telomerase activity appears to be independent of p53 mutations and clinical staging.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9600278</pmid><doi>10.1016/S0002-9610(98)00057-9</doi><tpages>3</tpages></addata></record> |
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| ispartof | The American journal of surgery, 1998-05, Vol.175 (5), p.364-366 |
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| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - genetics Adenocarcinoma - pathology Aged Base Sequence Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Cell proliferation Clinical Enzyme Tests - methods Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Male Medical sciences Molecular Sequence Data Mutation Neoplasm Staging p53 Protein Prospective Studies Regression Analysis Repetitive Sequences, Nucleic Acid Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Telomerase Telomerase - analysis Telomerase - genetics Tumor Suppressor Protein p53 - analysis Tumor Suppressor Protein p53 - genetics Tumors |
| title | The association between telomerase, p53, and clinical staging in colorectal cancer |
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