The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

Nijmegen breakage syndrome (NBS) is an autosomal recessive disorder characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity. We have isolated the gene encoding p95, a member of the hMre11/hRad50 double-strand break repair complex. The p95 gene m...

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Veröffentlicht in:	Cell 1998-05, Vol.93 (3), p.477-486
Hauptverfasser:	Carney, James P, Maser, Richard S, Olivares, Heidi, Davis, Elizabeth M, Le Beau, Michelle, Yates, John R, Hays, Lara, Morgan, William F, Petrini, John H.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Anhydride Hydrolases Cell Cycle Proteins - analysis Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - isolation & purification Cell Cycle Proteins - physiology Cell Line Chromosome Mapping Chromosomes, Human, Pair 8 - genetics Cloning, Molecular DNA Damage - genetics DNA Repair - genetics DNA Repair Enzymes DNA, Complementary - genetics DNA-Binding Proteins - analysis DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fibroblasts - radiation effects Genes, Recessive - genetics HeLa Cells Humans Microcephaly - genetics Molecular Sequence Data Molecular Weight MRE11 Homologue Protein Nuclear Proteins Proteins - analysis Proteins - genetics Proteins - metabolism Radiation Tolerance Radiation, Ionizing RNA, Messenger - analysis Sequence Homology, Amino Acid Species Specificity Syndrome
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