Acute Normovolemic Red Cell Exchange for Cardiopulmonary Bypass in Sickle Cell Disease

A patient with sickle cell disease (hematocrit, 28.5%; hemoglobin S fraction, 79%), required mitral valve repair. Partial red cell removal and blood component sequestration with an autotransfusion device before cardiopulmonary bypass initially decreased the sickle red cell mass. This was followed by...

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Veröffentlicht in:The Annals of thoracic surgery 1998-05, Vol.65 (5), p.1444-1446
Hauptverfasser: Shulman, Gerald, McQuitty, Christopher, Vertrees, Roger A, Conti, Vincent R
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container_end_page 1446
container_issue 5
container_start_page 1444
container_title The Annals of thoracic surgery
container_volume 65
creator Shulman, Gerald
McQuitty, Christopher
Vertrees, Roger A
Conti, Vincent R
description A patient with sickle cell disease (hematocrit, 28.5%; hemoglobin S fraction, 79%), required mitral valve repair. Partial red cell removal and blood component sequestration with an autotransfusion device before cardiopulmonary bypass initially decreased the sickle red cell mass. This was followed by an acute one-volume whole blood exchange transfusion performed upon the initiation of cardiopulmonary bypass, resulting in a further reduction. Both techniques yielded fresh autologous plasma for use; sequestration yielded a plateletpheresis product. Adequate postbypass hemostasis was demonstrated.
doi_str_mv 10.1016/S0003-4975(98)00038-1
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Partial red cell removal and blood component sequestration with an autotransfusion device before cardiopulmonary bypass initially decreased the sickle red cell mass. This was followed by an acute one-volume whole blood exchange transfusion performed upon the initiation of cardiopulmonary bypass, resulting in a further reduction. Both techniques yielded fresh autologous plasma for use; sequestration yielded a plateletpheresis product. Adequate postbypass hemostasis was demonstrated.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/S0003-4975(98)00038-1</identifier><identifier>PMID: 9594885</identifier><identifier>CODEN: ATHSAK</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Anemia, Sickle Cell - blood ; Anemia, Sickle Cell - prevention &amp; control ; Anesthesia ; Anesthesia depending on type of surgery ; Anesthesia. Intensive care medicine. Transfusions. 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subjects Adolescent
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - prevention & control
Anesthesia
Anesthesia depending on type of surgery
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Transfusion, Autologous
Blood Volume
Cardiopulmonary Bypass
Cytapheresis
Erythrocyte Volume
Erythrocytes - pathology
Exchange Transfusion, Whole Blood
Heart Valve Prosthesis Implantation
Hematocrit
Hemoglobin, Sickle - analysis
Hemostasis
Humans
Male
Medical sciences
Mitral Valve - surgery
Plasma
Plateletpheresis
Thoracic and cardiovascular surgery. Cardiopulmonary bypass
title Acute Normovolemic Red Cell Exchange for Cardiopulmonary Bypass in Sickle Cell Disease
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