Antitumoral effects of R 75251 on the growth of transplantable R3327 prostatic adenocarcinoma in rats

The antitumoral activity of a novel imidazole derivative, R 75251, has been studied in the androgen‐dependent R3327G Dunning prostate adenocarcinoma grafted subcutaneously in syngeneic rats. Dietary application resulting approximately in dose levels of 80, 120, and 160 mg/kg reduced tumor weight by...

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Veröffentlicht in:	The Prostate 1990, Vol.16 (4), p.313-323
Hauptverfasser:	Van Ginckel, R., De Coster, R., Wouters, W., Vanherck, W., Van Veer, R. Der, Goeminne, N., Jagers, E., Van Cauteren, H., Wouters, L., Distelmans, W., Janssen, P. A. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - pathology Animals Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Chemotherapy Dunning prostate adenocarcinoma Imidazoles - therapeutic use intact and castrated animals Male Medical sciences Neoplasm Transplantation Orchiectomy Pharmacology. Drug treatments Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Rats Rats, Inbred F344 Testosterone - pharmacology
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